Literature summary for 3.5.4.16 extracted from

Serova, L.I.; Filipenko, M.; Schilt, N.; Veerasirikul, M.; Sabban, E.L.
Estrogen-triggered activation of GTP cyclohydrolase 1 gene expression: Role of estrogen receptor subtypes and interaction with cyclic AMP (2006), Neuroscience, 140, 1253-1263.

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Activating Compound

Activating Compound	Comment	Organism	Structure
17beta-estradiol	can regulate GTPCH gene expression via transcriptional mechanisms	Rattus norvegicus
additional information	estrogen-triggered activation of GTP cyclohydrolase 1 gene expression, time course in transfected cells and mechanism, overview	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in PC-12 cells	Rattus norvegicus
transient co-expression of the enzyme with estrogen receptors in PC12 cells	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Rattus norvegicus	estrogens play a regulatory role on the enzyme expression, the enzyme is involved in estrogen receptor interaction with cyclic AMP, role of receptor subtypes, overview	formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Rattus norvegicus	formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate	-	?
GTP + H2O	estrogens play a regulatory role on the enzyme expression, the enzyme is involved in estrogen receptor interaction with cyclic AMP, role of receptor subtypes, overview	Rattus norvegicus	formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate	-	?
GTP + H2O	-	Rattus norvegicus	formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate	-	?

Synonyms

Synonyms	Comment	Organism
GTPCH	-	Rattus norvegicus

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Release 2023.1 (January 2023)