Information on EC 1.4.3.22 - diamine oxidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

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EC NUMBER
COMMENTARY hide
1.4.3.22
-
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RECOMMENDED NAME
GeneOntology No.
diamine oxidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
beta-alanine biosynthesis I
-
-
histamine degradation
-
-
N-methyl-Delta1-pyrrolinium cation biosynthesis
-
-
alanine metabolism
-
-
histidine metabolism
-
-
Arginine and proline metabolism
-
-
Histidine metabolism
-
-
Tryptophan metabolism
-
-
Metabolic pathways
-
-
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SYSTEMATIC NAME
IUBMB Comments
histamine:oxygen oxidoreductase (deaminating)
A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
top
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
groundnut
-
-
Manually annotated by BRENDA team
KAIT-B-007
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
hybrid
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
cultivar Changchun mici and Jinchun no. 2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
sweet pea
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
rice
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
clover
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(8-arginine)-vasopressin + H2O + O2
?
show the reaction diagram
-
-
-
-
?
(8-lysine)-vasopressin + H2O + O2
?
show the reaction diagram
-
-
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
show the reaction diagram
1,10-diaminodecane + H2O + O2
10-aminodecanal + NH3 + H2O2
show the reaction diagram
1,2-diaminoethane + H2O + O2
2-aminoethanal + NH3 + H2O2
show the reaction diagram
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
show the reaction diagram
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
show the reaction diagram
1,4-methylhistamine + H2O + O2
?
show the reaction diagram
-
-
-
?
1,5-diamino-3-oxapentane + H2O + O2
?
show the reaction diagram
-
the relative reaction rate with is 13% of that with putrescine
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
show the reaction diagram
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
show the reaction diagram
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
show the reaction diagram
1,8-diamino-3,6-dioxaoctane + H2O + O2
?
show the reaction diagram
-
the relative reaction rate with is 20% of that with putrescine
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
show the reaction diagram
1,9-diaminononane + H2O + O2
9-aminononanal + NH3 + H2O2
show the reaction diagram
-
-
-
?
1-aminobutane + H2O + O2
butanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1-aminononane + H2O + O2
nonanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1-methylhistamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
1-phenylethylamine + H2O + O2
1-phenylethanal + NH3 + H2O2
show the reaction diagram
2-(3,4-dihydroxyphenyl)-ethylamine + H2O + O2
3,4-dihydroxyphenylacetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
?
2-aminoethylpyridine + H2O + O2
pyridin-2-ylacetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
2-aminomethylpyridine + H2O + O2
2-formylpyridine + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
2-aminomethylpyridine + H2O + O2
pyridinaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
2-hydroxycadaverine + H2O + O2
?
show the reaction diagram
2-hydroxyputrescine + H2O + O2
2-hydroxy-4-aminobutanal + H2O2 + NH3
show the reaction diagram
2-hydroxyputrescine + H2O + O2
?
show the reaction diagram
2-methylhistamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
show the reaction diagram
3,3'-diaminobenzidine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
3-aminomethylpyridine + H2O + O2
3-formylpyridine + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
3-hydroxycadaverine + H2O + O2
3-hydroxy-4-aminopentanal + H2O2 + NH3
show the reaction diagram
3-hydroxycadaverine + H2O + O2
?
show the reaction diagram
4-aminomethylpyridine + H2O + O2
4-formylpyridine + NH3 + H2O2
show the reaction diagram
4-aminomethylpyridine dihydrochloride + H2O + O2
?
show the reaction diagram
8% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (putrescine, 1 mM) for various amine oxidases
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
show the reaction diagram
5-methylhistamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
agmatine
?
show the reaction diagram
agmatine + H2O + O2
?
show the reaction diagram
agmatine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
aminobutane + H2O + O2
butanal + NH3 + H2O2
show the reaction diagram
aminohexane + H2O + O2
hexanal + NH3 + H2O2
show the reaction diagram
aminopentane + H2O + O2
pentanal + NH3 + H2O2
show the reaction diagram
-
-
?
aminopropane + H2O + O2
propanal + NH3 + H2O2
show the reaction diagram
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
show the reaction diagram
benzylamine + O2 + H2O
benzaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
beta-phenylethylamine + O2 + H2O
beta-phenylethanal + NH3 + H2O2
show the reaction diagram
-
-
-
?
butylamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
show the reaction diagram
-
22% of the activity with histamine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
show the reaction diagram
cadaverine + H2O + O2
?
show the reaction diagram
cadaverine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
collagen + H2O + O2
?
show the reaction diagram
-
-
-
-
?
cystamine + H2O + O2
2-mercaptoethanal + H2O2 + NH3
show the reaction diagram
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
show the reaction diagram
ethylenediamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
hexylamine + H2O + O2
hexanal + NH3 + H2O2
show the reaction diagram
-
41% of the activity with histamine
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
show the reaction diagram
histamine + H2O + O2
?
show the reaction diagram
-
48% activity compared to putrescine
-
-
?
histamine + O2 + H2O
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
show the reaction diagram
DAO
-
-
?
L-lysine methyl ester + H2O + O2
?
show the reaction diagram
lysine + H2O + O2
2-aminohexanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
?
methylhistamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
N(pi)-methylhistamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
N(tau)-methylhistamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
N-(2-fluoroethyl)putrescine + H2O + O2
N-(2-fluoroethyl)aminobutanal + NH3 + H2O2
show the reaction diagram
-
same activity as with N-methylputrescine as substrate
-
-
?
N-acetyl-1,4-diaminobutane + H2O + O2
N-acetyl-aminobutanal + acetylamine + H2O2
show the reaction diagram
-
8.6% of activity with putrescine
-
?
N-acetyl-1,5-diaminopentane + H2O + O2
N-acetyl-aminopentanal + acetylamine + H2O2
show the reaction diagram
-
3.8% of activity with putrescine
-
?
N-ethylcadaverine + H2O + O2
5-(ethylamino)pentanal + NH3 + H2O2
show the reaction diagram
-
17% activity compared to activity with N-methylputrescine
-
-
?
N-ethylputrescine + H2O + O2
4-(ethylamino)butanal + NH3 + H2O2
show the reaction diagram
-
same activity as with N-methylputrescine as substrate
-
-
?
N-methyl-1,3-diaminopropane + H2O + O2
N-methyl-3-aminopropanal + NH3 + H2O2
show the reaction diagram
N-methylcadaverine + H2O + O2
5-(methylamino)pentanal + NH3 + H2O2
show the reaction diagram
-
16% activity compared to activity with N-methylputrescine
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
show the reaction diagram
N-n-propylputrescine + H2O + O2
4-propylaminobutanal + NH3 + H2O2
show the reaction diagram
-
50% of the activity compared to N-methylputrescine as substrate
-
-
-
N1-acetyl-spermidine + H2O + O2
?
show the reaction diagram
-
8.6% of activity with putrescine
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2
?
show the reaction diagram
N6-(4-aminobutyl)adenine + H2O + O2
?
show the reaction diagram
N8-acetylspermidine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
norepinephrine + H2O + O2
?
show the reaction diagram
-
-
-
?
octopamine + H2O + O2
?
show the reaction diagram
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
show the reaction diagram
pargyline + H2O + O2
?
show the reaction diagram
pentylamine + H2O + O2
pentanal + NH3 + H2O2
show the reaction diagram
-
32% of the activity with histamine
-
-
?
phenylethylamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
phenylethylamine + H2O + O2
phenylethanal + NH3 + H2O2
show the reaction diagram
propylamine + H2O + O2
propanal + NH3 + H2O2
show the reaction diagram
-
7% of the activity with histamine
-
-
?
putrescine + H2O + O2
?
show the reaction diagram
putrescine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
putrescine + H2O + O2
gamma-aminobutyraldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
show the reaction diagram
serotonin + H2O + O2
?
show the reaction diagram
-
-
-
?
spermidine + H2O + O2
1,3-diaminopropane + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
spermidine + H2O + O2
?
show the reaction diagram
spermidine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
spermine + H2O + O2
?
show the reaction diagram
spermine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
tropocollagen + H2O + O2
?
show the reaction diagram
-
-
-
-
?
tryptamine
?
show the reaction diagram
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
show the reaction diagram
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
tyramine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
show the reaction diagram
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
show the reaction diagram
tyramine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
tyramine + O2 + H2O
1H-indol-3-ylacetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
additional information
?
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
show the reaction diagram
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
show the reaction diagram
additional information
?
-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,4,5-trihydroxyphenylalanine quinone
2,4,5-trihydroxyphenylalaninequinone
-
1.1 mol per mol of dimer
FAD
-
4 molecules of FAD per dimer
L-topaquinone
-
-
-
pyridoxal 5'-phosphate
-
enzyme may contain pyridoxal phosphate
pyrroloquinoline quinone
topaquinone
-
trihydroxyphenylalanine quinone
-
additional information
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Al3+
-
activates
Co2+
-
activates
Manganese
MgSO4
-
10 mM, activation to 114% of control
NaCl
-
optimally active under high-salt conditions (3.5-5 M NaCl)
additional information
-
not influenced by Ca2+, Zn2+, Mn2+, and Ba2+
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-1,4-diamino-2-butene
-
0.1 mM, 72% and 87% inhibition; 0.1 mM, 72% and 87% inhibition
(Z)-1,4-diamino-2-butene
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
-
i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo
1,10-phenanthroline
-
10 mM, 47% inhibition
1,3-Diaminopropane
1,4-Diamino-2-butanone
1,4-diamino-2-butyne
1,4-diaminocyclohexane
-
5 mM, 69% inhibition
1,4-phenanthroline
1,5-Diamino-3-pentanone
1,6-diamino-3-azahexane
-
competitive
1,8-diamino-3,6-dioxaoctane
-
-
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
1-amino-3-phenyl-3-propanone
-
;
1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
2,2'-dipyridiyl
-
-
2,2'-dipyridyl
2,4-Dinitrophenylhydrazine
-
1 mM, complete inhibition; 1 mM, complete inhibition
2-Bromoethylamine
-
-
2-ethylaminobenzylamine dihydrochloride
-
2-mercaptoethanol
2-methylaminobenzylamine dihydrochloride
-
2-methylbenzothiazoline hydrazone
-
competitive inhibition
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
3-amino-4-aminomethylpyridine dihydrochloride
-
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
3-methylamino-4-aminomethylpyridine dihydrochloride
-
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
4,4'-(pentane-1,5-diylbis(oxy))dibenzimidamide
noncompetitive inhibition
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
4-(aminomethyl)-N,N'-bis(1-methylethyl)pyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
-
8-hydroxyquinoline
adenosine 3',5'-AMP
-
-
alpha,alpha'-dipyridyl
-
10 mM, 22% inhibition
amiloride
-
diuretic drug, competitive vs. agmatine and putrescine oxidation
aminoacetonitrile
aminoguanidine
aniline
-
10 mM, 43% inhibition
Arcaine sulfate
azide
benzylhydrazine
-
-
Berenil
mixed inhibition
beta-aminopropionitrile
beta-Bromoethylamine
beta-hydroxyethylhydrazine
Ca2+
-
10 mM, 37% inhibition
CaCl2
-
1 mM, slightly inhibited,less than 24%
CdCl2
-
1 mM, strongly inhibited,more than 90%
chinconine
-
-
-
cimetidine
mixed inhibition
clonidine
CoCl2
-
1 mM, moderately inhibited,60-80%
CuCl2
-
1 mM, strongly inhibited,more than 90%
Cuprizone
cyanide
Cyclohexylamine
-
10 mM, 93% inhibition
diaminoacetone
Dicyclohexylamine
-
10 mM, 79% inhibition
Diethyl dithiocarbamate
-
10 mM, 76% inhibition
diethyldithiocarbamate
diethylenetriamine
-
powerful noncompetitive inhibitor
Diethylthiocarbamate
-
-
diminazene aceturate
-
-
dithiothreitol
-
10 mM, 12% inhibition
EDTA-Na2
-
76.47% residual activity at 1 mM
EGTA
-
71.57% residual activity at 1 mM
Fe3+
-
10.78% residual activity at 3 mM
FeSO4
-
1 mM, moderately inhibited,60-80%
gabexate mesylate
-
anti coagulant drug, competitive vs. agmatine and putrescine oxidation
glutathione
HgCl2
-
1 mM, strongly inhibited,more than 90%
histamine
hydrazine
-
10 mM, 95% inhibition
hydroxylamine
Hydroxyquinoline
Iproniazid
Iproniazide
-
10 mM, 43% inhibition
Isoniazid
isoniazide
-
10 mM, 76% inhibition
Isonicotinic acid hydrazide
-
-
KMnO4
-
0.1 mM, complete inhibition
L-cysteine
-
complete inhibition at 0.1 mM
L-lobeline
-
-
m-phenylenediamine
-
competitive vs. cadaverine
methylglyoxalbis(guanylhydrazone)
-
without preincubation competitive inhibitor, non-competitive after 1 h preincubation
methylhydrazine
-
10 mM, complete inhibition
MgCl2
-
1 mM, slightly inhibited,less than 24%
MnCl2
-
1 mM, slightly inhibited,less than 24%
N,N-diethyldithiocarbamate
-
the inactive enzyme is restored with Cu2+ to 65% of its initial activity
n-butylamine
N-ethylmaleimide
-
1 mM, 90% inhibition
N-methyl-1,3-diamonopropane
N-methylbutylamine
N-Methylmaleimide
-
59% inhibition at 1 mM
N-methylpropylamine
n-Propylamine
N1,N2-bis(2-pyridinylmethyl)-1,2-ethanediamine
-
competitive
N1,N3-bis(2-pyridinylmethyl)-1,3-propanediamine
-
-
N1,N4-bis(2-pyridinylmethyl)-1,4-butanediamine
-
-
N1,N5-bis(2-pyridinylmethyl)-1,5-pentanediamine
-
-
N1,N6-bis(2-pyridinylmethyl)-1,6-hexanediamine
-
-
N1,N7-bis(2-pyridinylmethyl)-1,7-heptanediamine
-
-
N1,N8-bis(2-pyridinylmethyl)-1,8-octanediamine
-
-
N3-
-
-
N6-(3-aminopropyl)adenine
N6-(4-amino-cis-but-2-enyl)adenine
Na2S2O3
NaCl
-
200 mM, approx. 50% inhibition, almost complete inhibition of the purified enzyme with 1 M NaCl
NaHSO3
NH3
-
competitive vs. p-dimethylaminomethylbenzylamine, uncompetitive vs. O2
Ni2+
-
0.5 mM, 92% inhibition
NiCl2
-
1 mM, moderately inhibited,60-80%
o-phenanthroline
o-phenyldiamine
-
-
o-phenylenediamine
-
competitive vs. cadaverine
p-chloromercuribenzenesulfonic acid
-
91% inhibition at 1 mM
p-Chloromercuriphenylsulfonate
-
1 mM, complete inhibition
p-Nitrophenylhydrazine
-
1 mM, complete inhibition; 1 mM, complete inhibition
Pentamidine
mixed inhibition
phenylhydrazine
piperidine
-
10 mM, 55% inhibition
Pyridoxine-HCl
-
10 mM, 72% inhibition
Quinacrine
sanguinarine
-
0.1 mM, 65% inhibition; 0.1 mM, 65% inhibition
SCN-
-
-
Semicarbazide
Sodium cyanide
-
-
spermidine
-
substrate inhibition
Thiocyanate
-
uncompetitive vs. p-dimethylaminomethylbenzylamine, SCN- is equatorially coordinated to a tetragonal Cu(II) center
Tranylcypromine
triethylenetetramine
-
powerful inhibitor
triethyltetramine
ZnCl2
-
1 mM, slightly inhibited,less than 24%
additional information
-
top print hide
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NaCl
-
in comparison to cultivar Jinchun no. 2, cultivar Changchun mici shows an increase in diamine oxidase activity as well as free spermidine and spermine, soluble conjugated and insoluble bound putrescine, spermidine and spermine contents in the roots during exposure to salinity (50 mM NaCl).
top print hide
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
(E)-1,4-diamino-2-butene
0.13 - 17
1,3-Diaminopropane
0.36
1,4-diamino-2-butene
-
-
0.2 - 2.85
1,4-diaminobutane
0.14
1,4-methylhistamine
-
-
0.2
1,5-diamino-3-oxapentane
-
-
0.47
1,5-Diaminopentane
-
-
0.11 - 0.15
1,6-diaminohexane
0.00036
1,8-diaminooctane
-
pH 7.2, 37°C
2.5
1-aminobutane
-
pH 7.2, 37°C
0.0087
1-aminononane
-
pH 7.2, 37°C
0.0034
1-Methylhistamine
-
pH 7.2, 37°C
0.051 - 0.16
2-aminoethylpyridine
0.005 - 0.031
2-aminomethylpyridine
0.67
2-hydroxyputrescine
0.12
2-Phenylethylamine
-
-
0.21 - 0.58
3-aminomethylpyridine
0.09
3-hydroxycadaverine
0.1 - 0.48
4-aminomethylpyridine
0.004
4-aminomethylpyridine dihydrochloride
-
3.28
Acetylcadaverine
-
-
9.71
acetylputrescine
-
-
0.017 - 0.5
agmatine
0.6
aminobutane
-
-
0.15 - 0.2
aminohexane
0.35
aminopentane
-
-
1.6
Aminopropane
-
-
0.12 - 2.2
benzaldehyde
0.1 - 4.1
benzylamine
0.877 - 5
Butylamine
0.0146 - 8.1
cadaverine
0.1
cystamine
0.6
dopamine
-
-
66
ethylamine
-
at pH 7.4
0.63 - 66
ethylenediamine
0.0028 - 1.8
histamine
2.8
L-Lysine methyl ester
-
pH 7.2, 37°C
6.5
lysine methylester
-
at pH 7.4
0.075 - 0.158
Methylhistamine
0.097
N(tau)-methylhistamine
-
-
0.19 - 1.22
N-methylputrescine
0.625
N1-acetylspermidine
-
-
0.15 - 0.33
N6-(4-amino-trans-but-2-enyl)adenine
0.25 - 0.77
N6-(4-aminobutyl)adenine
0.64
N8-Acetylspermidine
-
pH 7.2, 37°C
1.05
norepinephrine
-
-
0.00037 - 0.046
O2
0.36
octopamine
-
-
0.11
p-dimethylaminomethylbenzylamine
-
pH 7.2, 37°C
0.0015 - 1.4
Phenylethylamine
3.4 - 6.6
Propylamine
0.01 - 7
putrescine
0.29
serotonin
-
-
0.022 - 9.52
spermidine
0.02 - 5.71
spermine
0.1
tryptamine
-
-
0.12 - 3.1
tyramine
additional information
additional information
-
the kinetic properties of the MPO1 enzyme may play an important role in determining the pyridine alkaloid profiles observed in tobacco roots
-