Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(8-arginine)-vasopressin + H2O + O2
?
-
-
-
-
?
(8-lysine)-vasopressin + H2O + O2
?
-
-
-
-
?
(E)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
1,10-diaminodecane + H2O + O2
10-aminodecanal + NH3 + H2O2
1,2-diaminoethane + H2O + O2
2-aminoethanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
1,4-methylhistamine + H2O + O2
?
-
-
-
?
1,5-diamino-3-oxapentane + H2O + O2
?
-
the relative reaction rate with is 13% of that with putrescine
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
1,8-diamino-3,6-dioxaoctane + H2O + O2
?
-
the relative reaction rate with is 20% of that with putrescine
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
1,9-diaminononane + H2O + O2
9-aminononanal + NH3 + H2O2
-
-
-
?
1-aminobutane + H2O + O2
butanal + NH3 + H2O2
-
-
-
-
?
1-aminononane + H2O + O2
nonanal + NH3 + H2O2
-
-
-
-
?
1-methylhistamine + H2O + O2
?
-
-
-
-
?
1-phenylethylamine + H2O + O2
1-phenylethanal + NH3 + H2O2
2-(3,4-dihydroxyphenyl)-ethylamine + H2O + O2
3,4-dihydroxyphenylacetaldehyde + NH3 + H2O2
-
-
?
2-aminoethylpyridine + H2O + O2
pyridin-2-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
2-aminomethylpyridine + H2O + O2
2-formylpyridine + NH3 + H2O2
-
-
-
-
?
2-aminomethylpyridine + H2O + O2
2-pyridinaldehyde + NH3 + H2O2
-
-
-
-
?
2-hydroxycadaverine + H2O + O2
?
2-hydroxyputrescine + H2O + O2
2-hydroxy-4-aminobutanal + H2O2 + NH3
2-hydroxyputrescine + H2O + O2
?
2-methylhistamine + H2O + O2
?
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
r
3,3'-diaminobenzidine + H2O + O2
?
-
-
-
-
?
3-aminomethylpyridine + H2O + O2
3-formylpyridine + NH3 + H2O2
-
-
-
-
?
3-hydroxycadaverine + H2O + O2
3-hydroxy-4-aminopentanal + H2O2 + NH3
3-hydroxycadaverine + H2O + O2
?
4-aminomethylpyridine + H2O + O2
4-formylpyridine + NH3 + H2O2
4-aminomethylpyridine dihydrochloride + H2O + O2
?
8% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (putrescine, 1 mM) for various amine oxidases
-
-
?
4-dimethylaminomethylbenzylamine + H2O + O2
4-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
-
r
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
5-methylhistamine + H2O + O2
?
-
-
-
-
?
agmatine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
aminobutane + H2O + O2
butanal + NH3 + H2O2
aminohexane + H2O + O2
hexanal + NH3 + H2O2
aminopentane + H2O + O2
pentanal + NH3 + H2O2
-
-
?
aminopropane + H2O + O2
propanal + NH3 + H2O2
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
benzylamine + O2 + H2O
benzaldehyde + NH3 + H2O2
-
-
-
?
beta-phenylethylamine + O2 + H2O
beta-phenylethanal + NH3 + H2O2
-
-
-
?
butylamine + H2O + O2
?
-
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
cadaverine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
collagen + H2O + O2
?
-
-
-
-
?
cystamine + H2O + O2
2-mercaptoethanal + H2O2 + NH3
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
r
ethylenediamine + H2O + O2
?
hexylamine + H2O + O2
hexanal + NH3 + H2O2
-
41% of the activity with histamine
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
histamine + H2O + O2
?
-
48% activity compared to putrescine
-
-
?
histamine + O2 + H2O
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
DAO
-
-
?
L-lysine methyl ester + H2O + O2
?
lysine + H2O + O2
2-aminohexanoic acid + NH3 + H2O2
-
-
-
?
methylhistamine + H2O + O2
?
-
-
-
-
?
N(pi)-methylhistamine + H2O + O2
?
-
-
-
-
?
N(tau)-methylhistamine + H2O + O2
?
-
-
-
-
?
N-(2-fluoroethyl)putrescine + H2O + O2
N-(2-fluoroethyl)aminobutanal + NH3 + H2O2
-
same activity as with N-methylputrescine as substrate
-
-
?
N-acetyl-1,4-diaminobutane + H2O + O2
N-acetyl-aminobutanal + acetylamine + H2O2
-
8.6% of activity with putrescine
-
?
N-acetyl-1,5-diaminopentane + H2O + O2
N-acetyl-aminopentanal + acetylamine + H2O2
-
3.8% of activity with putrescine
-
?
N-acetylcadaverine + H2O + O2
?
-
-
-
-
r
N-ethylcadaverine + H2O + O2
5-(ethylamino)pentanal + NH3 + H2O2
-
17% activity compared to activity with N-methylputrescine
-
-
?
N-ethylputrescine + H2O + O2
4-(ethylamino)butanal + NH3 + H2O2
-
same activity as with N-methylputrescine as substrate
-
-
?
N-methyl-1,3-diaminopropane + H2O + O2
N-methyl-3-aminopropanal + NH3 + H2O2
N-methylcadaverine + H2O + O2
5-(methylamino)pentanal + NH3 + H2O2
-
16% activity compared to activity with N-methylputrescine
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
N-n-propylputrescine + H2O + O2
4-propylaminobutanal + NH3 + H2O2
-
50% of the activity compared to N-methylputrescine as substrate
-
-
?
N1-acetyl-spermidine + H2O + O2
?
-
8.6% of activity with putrescine
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2
?
N6-(4-aminobutyl)adenine + H2O + O2
?
N8-acetylspermidine + H2O + O2
?
-
-
-
-
?
norepinephrine + H2O + O2
?
-
-
-
?
octopamine + H2O + O2
?
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
?
-
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
pentylamine + H2O + O2
pentanal + NH3 + H2O2
-
32% of the activity with histamine
-
-
?
phenylethylamine + H2O + O2
?
-
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
phenylethylamine + H2O + O2
phenylethanal + NH3 + H2O2
propylamine + H2O + O2
propanal + NH3 + H2O2
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
putrescine + H2O + O2
? + NH3 + H2O2
putrescine + H2O + O2
gamma-aminobutyraldehyde + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
serotonin + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
1,3-diaminopropane + NH3 + H2O2
-
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
spermine + H2O + O2
? + NH3 + H2O2
tropocollagen + H2O + O2
?
-
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
tyramine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
tyramine + O2 + H2O
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
?
additional information
?
-
(E)-1,4-diamino-2-butene + H2O + O2

4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
(E)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
(E,Z)-1,4-diamino-2-butene + H2O + O2

4-aminobut-2-enal + NH3 + H2O2
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
1,10-diaminodecane + H2O + O2

10-aminodecanal + NH3 + H2O2
-
-
-
?
1,10-diaminodecane + H2O + O2
10-aminodecanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2

3-aminopropanal + NH3 + H2O2
-
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
109% of activity with putrescine
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
30% activity compared to activity with N-methylputrescine
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
30% activity compared to activity with putrescine
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2

4-aminobutanal + NH3 + H2O2
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
56% activity compared to activity with N-methylputrescine
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
50% activity compared to activity with N-methylputrescine
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
best substrate
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
best substrate
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2

5-aminopentanal + NH3 + H2O2
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
most active
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
60% of activity with putrescine
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2

6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2

7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,8-diaminooctane + H2O + O2

8-aminooctanal + NH3 + H2O2
-
-
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
-
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
-
-
-
?
1-phenylethylamine + H2O + O2

1-phenylethanal + NH3 + H2O2
-
44% of the activity with histamine
-
-
?
1-phenylethylamine + H2O + O2
1-phenylethanal + NH3 + H2O2
-
44% of the activity with histamine
-
-
?
2-hydroxycadaverine + H2O + O2

?
-
-
-
-
?
2-hydroxycadaverine + H2O + O2
?
-
-
-
-
?
2-hydroxyputrescine + H2O + O2

2-hydroxy-4-aminobutanal + H2O2 + NH3
-
-
-
?
2-hydroxyputrescine + H2O + O2
2-hydroxy-4-aminobutanal + H2O2 + NH3
-
-
-
?
2-hydroxyputrescine + H2O + O2

?
-
-
-
-
?
2-hydroxyputrescine + H2O + O2
?
-
-
-
-
?
2-phenylethylamine + H2O + O2

2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
3-hydroxycadaverine + H2O + O2

3-hydroxy-4-aminopentanal + H2O2 + NH3
-
-
-
?
3-hydroxycadaverine + H2O + O2
3-hydroxy-4-aminopentanal + H2O2 + NH3
-
-
-
?
3-hydroxycadaverine + H2O + O2

?
-
-
-
-
?
3-hydroxycadaverine + H2O + O2
?
-
-
-
-
?
4-aminomethylpyridine + H2O + O2

4-formylpyridine + NH3 + H2O2
-
-
-
-
?
4-aminomethylpyridine + H2O + O2
4-formylpyridine + NH3 + H2O2
-
-
-
-
?
4-phenylbutylamine + H2O + O2

4-phenylbutanal + NH3 + H2O2
-
72.6% of the activity with tyramine
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
53.6% of the activity with tyramine
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
19.3% of the activity with cadaverine
-
-
?
agmatine

?
-
14% of activity with putrescine
-
-
?
agmatine + H2O + O2

?
-
4% of the activity with histamine
-
-
?
agmatine + H2O + O2
?
-
4% of the activity with histamine
-
-
?
agmatine + H2O + O2
?
-
-
-
-
?
aminobutane + H2O + O2

butanal + NH3 + H2O2
-
-
?
aminobutane + H2O + O2
butanal + NH3 + H2O2
-
-
?
aminohexane + H2O + O2

hexanal + NH3 + H2O2
-
-
?
aminohexane + H2O + O2
hexanal + NH3 + H2O2
-
-
?
benzylamine + H2O + O2

benzaldehyde + NH3 + H2O2
-
88.5% of the activity with tyramine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
29% activity compared to putrescine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
15.3% of the activity with tyramine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
66.5% of the activity with cadaverine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
butylamine + H2O + O2

butanal + NH3 + H2O2
-
22% of the activity with histamine
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
-
-
-
-
r
cadaverine + H2O + O2

5-aminopentanal + NH3 + H2O2
-
15% activity compared to activity with N-methylputrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
r
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
30% activity compared to activity with N-methylputrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
75% activity compared to activity with putrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
80% activity compared to activity with putrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
r
cadaverine + H2O + O2

?
-
15.1% of the activity with tyramine
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
cadaverine + H2O + O2
?
-
12.0% of the activity with tyramine
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
cystamine + H2O + O2

2-mercaptoethanal + H2O2 + NH3
-
-
-
?
cystamine + H2O + O2
2-mercaptoethanal + H2O2 + NH3
-
-
-
?
dopamine + H2O + O2

2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
51% of the activity with histamine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
93.7% of the activity with tyramine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
62.3% of the activity with tyramine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
18.4% of the activity with cadaverine
-
-
?
ethylenediamine + H2O + O2

?
-
-
-
-
?
ethylenediamine + H2O + O2
?
-
-
-
-
r
histamine + H2O + O2

(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
28% of activity with putrescine
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
preferred substrate
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
60% activity compared to activity with putrescine
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
L-lysine methyl ester + H2O + O2

?
-
-
-
-
?
L-lysine methyl ester + H2O + O2
?
-
-
-
-
?
N-methyl-1,3-diaminopropane + H2O + O2

N-methyl-3-aminopropanal + NH3 + H2O2
-
40% activity compared to activity with N-methylputrescine
-
-
?
N-methyl-1,3-diaminopropane + H2O + O2
N-methyl-3-aminopropanal + NH3 + H2O2
-
40% activity compared to activity with putrescine
-
-
?
N-methylputrescine + H2O + O2

4-(methylamino)butanal + NH3 + H2O2
-
best substrate
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
best substrate. Specificity for N-methylated diamines enable the Hyoscyamine enzyme to function specifically in tropane alkaloid biosynthesis
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
-
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
50% activity compared to activity with putrescine
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
75% activity compared to activity with putrescine
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2

?
-
-
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-aminobutyl)adenine + H2O + O2

?
-
-
-
-
?
N6-(4-aminobutyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-aminobutyl)adenine + H2O + O2
?
-
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2

p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
pargyline + H2O + O2

?
-
14.4% of the activity with tyramine
-
-
?
pargyline + H2O + O2
?
-
13.7% of the activity with tyramine
-
-
?
pargyline + H2O + O2
?
-
17.3% of the activity with cadaverine
-
-
?
phenylethylamine + H2O + O2

phenylacetaldehyde + NH3 + H2O2
-
-
-
-
r
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2

phenylethanal + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
phenylethanal + NH3 + H2O2
-
-
-
-
?
propylamine + H2O + O2

propanal + NH3 + H2O2
-
7% of the activity with histamine
-
-
?
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
-
r
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
-
r
putrescine + H2O + O2

4-aminobutanal + NH3 + H2O2
-
-
-
-
r
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
-
r
putrescine + H2O + O2

?
-
12.6% of the activity with tyramine
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
100% activity
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
catalytic activity of xenon-treated LSAO towards putrescine is about 40% of that of the native LSAO
-
-
?
putrescine + H2O + O2
?
-
11.5% of the activity with tyramine
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
96.2% of the activity with cadaverine
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
putrescine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
putrescine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2

RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with spermidine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with benzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with p-dimethylaminomethylbenzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
only aliphatic diamines from C4 to C10 and cystamine are oxidized, enzymatic activity decreases sharply with increasing chain length of diamines
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
short-chain aliphatic diamines are deaminated with highest reaction velocity
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with benzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with benzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
treatment of diamine oxidase with reducing agents induces ability to catalyze oxidative deamination of substrates of monoamine oxidase EC 1.4.3.4
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
spermidine + H2O + O2

?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
71% activity compared to putrescine
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
r
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
spermine + H2O + O2

?
-
-
-
-
?
spermine + H2O + O2
?
-
no reaction
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
42% activity compared to putrescine
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
spermine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
tryptamine

?
-
-
-
?
tryptamine + H2O + O2

1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
15% of the activity with histamine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
35.2% of the activity with tyramine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
48.4% of the activity with tyramine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
15.7% of the activity with cadaverine
-
-
?
tyramine + H2O + O2

1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2

4-hydroxyphenylethanal + NH3 + H2O2
-
36% of the activity with histamine
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
36% of the activity with histamine
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
19.1% of the activity with cadaverine
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
additional information

?
-
-
no activity with putrescine, cadaverine, spermine, and spermidine
-
-
?
additional information
?
-
-
no activity with putrescine, cadaverine, spermine, and spermidine
-
-
?
additional information
?
-
-
relevance of the enzyme as a H2O2-delivering system in wound response, as well as in the protection against fungal invasion
-
-
?
additional information
?
-
-
polyamine degradation via DAO produces DELTA1-pyrroline, DELTA1-pyrroline can be catabolized to gamma-aminobutyric acid, which is converted via transamination and oxidation to succinate and successively introduced in the Krebs cycle.
-
-
?
additional information
?
-
hDAO is unique among CAOs in that it has a distinct substrate preference for diamines
-
-
?
additional information
?
-
-
hDAO is unique among CAOs in that it has a distinct substrate preference for diamines
-
-
?
additional information
?
-
active site of hDAO: contacts made by cofactor trihydroxyphenylalanine quinone to the active-site Cu2+, and Thr685 and to a glycerol molecule within the active-site channel
-
-
?
additional information
?
-
-
active site of hDAO: contacts made by cofactor trihydroxyphenylalanine quinone to the active-site Cu2+, and Thr685 and to a glycerol molecule within the active-site channel
-
-
?
additional information
?
-
-
involvement of the enzyme in the supply of H2O2 to peroxidase-catalysed reactions in the chalazal cells during grain filling
-
-
?
additional information
?
-
-
low activity with histamine, n-butylamine, and 1,6-diaminohexane
-
-
?
additional information
?
-
-
low or no activity with 1,3-diaminopropane, N-methyl-1,3-diaminopropane, n-butylamine, 1,6-diaminohexane, and histamine
-
-
?
additional information
?
-
-
low activity with n-butylamine or 1,6-diaminohexane as substrate
-
-
?
additional information
?
-
-
the enzyme does not degrade spermine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(E)-1,4-diamino-2-butene
0.1 mM, 72% and 87% inhibition; 0.1 mM, 72% and 87% inhibition
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
-
i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo
1,10-phenanthroline
-
10 mM, 47% inhibition
1,4-diaminocyclohexane
-
5 mM, 69% inhibition
1,6-diamino-3-azahexane
-
competitive
1,8-diamino-3,6-dioxaoctane
-
-
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
1-amino-3-phenyl-3-propanone
-
1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
2,4-Dinitrophenylhydrazine
1 mM, complete inhibition; 1 mM, complete inhibition
2-ethylaminobenzylamine dihydrochloride
-
2-methylaminobenzylamine dihydrochloride
-
2-methylbenzothiazoline hydrazone
-
competitive inhibition
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
3-amino-4-aminomethylpyridine dihydrochloride
-
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
3-methylamino-4-aminomethylpyridine dihydrochloride
-
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
4,4'-(pentane-1,5-diylbis(oxy))dibenzimidamide
noncompetitive inhibition
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
4-(aminomethyl)-N,N'-bis(1-methylethyl)pyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
-
alpha,alpha'-dipyridyl
-
10 mM, 22% inhibition
amiloride
-
diuretic drug, competitive vs. agmatine and putrescine oxidation
aniline
-
10 mM, 43% inhibition
beta-hydroxyethylhydrazine
Ca2+
-
10 mM, 37% inhibition
CaCl2
-
1 mM, slightly inhibited,less than 24%
CdCl2
-
1 mM, strongly inhibited,more than 90%
cimetidine
mixed inhibition
CoCl2
-
1 mM, moderately inhibited,60-80%
CuCl2
-
1 mM, strongly inhibited,more than 90%
Cyclohexylamine
-
10 mM, 93% inhibition
Dicyclohexylamine
-
10 mM, 79% inhibition
Diethyl dithiocarbamate
-
10 mM, 76% inhibition
diethylenetriamine
-
powerful noncompetitive inhibitor
dithiothreitol
-
10 mM, 12% inhibition
EDTA-Na2
-
76.47% residual activity at 1 mM
EGTA
-
71.57% residual activity at 1 mM
Fe3+
-
10.78% residual activity at 3 mM
FeSO4
-
1 mM, moderately inhibited,60-80%
gabexate mesylate
-
anti coagulant drug, competitive vs. agmatine and putrescine oxidation
HgCl2
-
1 mM, strongly inhibited,more than 90%
hydrazine
-
10 mM, 95% inhibition
Iproniazide
-
10 mM, 43% inhibition
isoniazide
-
10 mM, 76% inhibition
Isonicotinic acid hydrazide
-
-
KMnO4
-
0.1 mM, complete inhibition
L-cysteine
-
complete inhibition at 0.1 mM
m-phenylenediamine
-
competitive vs. cadaverine
methylglyoxalbis(guanylhydrazone)
-
without preincubation competitive inhibitor, non-competitive after 1 h preincubation
methylhydrazine
-
10 mM, complete inhibition
MgCl2
-
1 mM, slightly inhibited,less than 24%
MnCl2
-
1 mM, slightly inhibited,less than 24%
N,N-diethyldithiocarbamate
-
the inactive enzyme is restored with Cu2+ to 65% of its initial activity
N-ethylmaleimide
-
1 mM, 90% inhibition
N-methyl-1,3-diamonopropane
N-Methylmaleimide
-
59% inhibition at 1 mM
N1,N2-bis(2-pyridinylmethyl)-1,2-ethanediamine
-
competitive
N1,N3-bis(2-pyridinylmethyl)-1,3-propanediamine
-
-
N1,N4-bis(2-pyridinylmethyl)-1,4-butanediamine
-
-
N1,N5-bis(2-pyridinylmethyl)-1,5-pentanediamine
-
-
N1,N6-bis(2-pyridinylmethyl)-1,6-hexanediamine
-
-
N1,N7-bis(2-pyridinylmethyl)-1,7-heptanediamine
-
-
N1,N8-bis(2-pyridinylmethyl)-1,8-octanediamine
-
-
N6-(3-aminopropyl)adenine
N6-(4-amino-cis-but-2-enyl)adenine
NaCl
-
200 mM, approx. 50% inhibition, almost complete inhibition of the purified enzyme with 1 M NaCl
NH3
-
competitive vs. p-dimethylaminomethylbenzylamine, uncompetitive vs. O2
Ni2+
-
0.5 mM, 92% inhibition
NiCl2
-
1 mM, moderately inhibited,60-80%
o-phenylenediamine
-
competitive vs. cadaverine
p-chloromercuribenzenesulfonic acid
-
91% inhibition at 1 mM
p-chloromercuriphenylsulfonate
-
1 mM, complete inhibition
p-Nitrophenylhydrazine
1 mM, complete inhibition; 1 mM, complete inhibition
Pentamidine
mixed inhibition
piperidine
-
10 mM, 55% inhibition
Pyridoxine-HCl
-
10 mM, 72% inhibition
sanguinarine
0.1 mM, 65% inhibition; 0.1 mM, 65% inhibition
spermidine
-
substrate inhibition
thiocyanate
-
uncompetitive vs. p-dimethylaminomethylbenzylamine, SCN- is equatorially coordinated to a tetragonal Cu(II) center
triethylenetetramine
-
powerful inhibitor
ZnCl2
-
1 mM, slightly inhibited,less than 24%
(Z)-1,4-diamino-2-butene

0.1 mM, 28% inhibition; 0.1 mM, 28% inhibition
(Z)-1,4-diamino-2-butene
-
-
1,3-diaminopropane

-
10 mM with 2 mM N-methylputrescine as substrate, 32% relative inhibition
1,3-diaminopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 70% relative inhibition
1,3-diaminopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 93% relative inhibition
1,4-Diamino-2-butanone

-
-
1,4-Diamino-2-butanone
-
-
1,4-Diamino-2-butanone
-
potent reversible inhibitors
1,4-Diamino-2-butanone
-
potent reversible inhibitors
1,4-diamino-2-butyne

-
-
1,4-phenanthroline

-
1,4-phenanthroline
-
1 mM, 71% inhibition
1,4-phenanthroline
-
0.1 mM
1,5-Diamino-3-pentanone

1 mM, 50% inhibition; 1 mM, 50% inhibition
1,5-Diamino-3-pentanone
-
-
1,5-Diamino-3-pentanone
-
-
1,5-Diamino-3-pentanone
-
-
1,5-Diamino-3-pentanone
-
potent reversible inhibitors
1,5-Diamino-3-pentanone
-
potent reversible inhibitors
2,2'-dipyridyl

-
2,2'-dipyridyl
-
1 mM, 74% inhibition
2-mercaptoethanol

-
10 mM, 26% inhibition
2-mercaptoethanol
-
0.1 mM, 89% inhibition
2-mercaptoethanol
-
2.94% residual activity at 0.5 mM
8-hydroxyquinoline

-
10 mM, 24% inhibition
8-hydroxyquinoline
-
1 mM, 49.3% inhibition
aminoacetonitrile

-
-
aminoguanidine

-
-
aminoguanidine
-
0.00001 mM, 50% inhibition, putrescine or histamine as substrates
aminoguanidine
-
0.02 mM, complete inhibition, oxidation of histamine
aminoguanidine
-
1 mM, complete inhibition
aminoguanidine
potent, irreversible inhibitor
aminoguanidine
-
66% inhibition at 10 mM
aminoguanidine
-
0.03 mM, complete inhibition
aminoguanidine
-
model of inhibition mechanism
aminoguanidine
-
3.92% residual activity at 0.25 mM
Arcaine sulfate

-
-
azide

-
noncompetitive with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction
azide
-
partially competitive with respect to oxidative half-reaction, competitive with respect to reductive half-reaction
azide
-
mode of inhibition is dependent of azide concentration with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction
azide
-
competitive with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction
beta-aminopropionitrile

-
-
beta-aminopropionitrile
-
-
beta-Bromoethylamine

-
-
beta-hydroxyethylhydrazine

-
0.0033 mM, with 0.01 mM tyramine, 89.4% inhibition
beta-hydroxyethylhydrazine
-
0.0033 mM, with 0.01 mM tyramine, 89.5% inhibition
beta-hydroxyethylhydrazine
-
0.0033 mM, with 0.01 mM cadaverine, 85.5% inhibition
clonidine

mixed inhibition
clonidine
-
antihypertensive drug, competitive vs. agmatine and putrescine oxidation
Cu2+

-
0.5 mM, 92% inhibition
Cu2+
-
7.84% residual activity at 3 mM
Cuprizone

-
-
cyanide

-
-
cyanide
-
1 mM, 76% inhibition
diaminoacetone

-
0.1 mM, significant inhibition
diaminoacetone
-
0.1 mM, significant inhibition
diethyldithiocarbamate

-
0.0033 mM, with 0.01 mM tyramine, 95.1% inhibition
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
1 mM, complete inhibition
diethyldithiocarbamate
-
59% inhibition at 0.1 mM
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
0.0033 mM, with 0.01 mM tyramine, 90.4% inhibition
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
0.0033 mM, with 0.01 mM cadaverine, 91.2% inhibition
diethyldithiocarbamate
-
-
EDTA

-
10 mM, 18% inhibition
EDTA
-
10 mM, 80% inhibition
glutathione

-
0.0033 mM, with 0.01 mM tyramine, 35.2% inhibition
glutathione
-
0.0033 mM, with 0.01 mM tyramine, 43.5% inhibition
glutathione
-
0.0033 mM, with 0.01 mM cadaverine, 38.1% inhibition
H2O2

-
inactivation by turnover products is a slow reaction of the reduced protein with H2O2 subsequent to turnover and occurs in a similar way for all amines
H2O2
-
uncompetitive vs. p-dimethylaminomethylbenzylamine
Hg2+

-
10 mM, 80% inhibition
Hg2+
-
0.5 mM, complete inactivation
histamine

-
-
histamine
-
substrate inhibition
hydroxylamine

-
40% inhibition at 0.01 mM
Hydroxyquinoline

-
-
Iproniazid

-
0.1 mM, 68% inhibition
Iproniazid
-
0.03 mM, 84% inhibition
isoniazid

-
-
isoniazid
noncompetitive inhibition
KCN

-
1 mM, inhibits activity completely, is used to stop the enzyme reaction
Mg2+

-
10 mM, 37% inhibition
Mg2+
-
78.43% residual activity at 3 mM
n-butylamine

-
10 mM with 2 mM N-methylputrescine as substrate, 19% relative inhibition
n-butylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 66% relative inhibition
n-butylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 60% relative inhibition
N-methyl-1,3-diamonopropane

-
10 mM with 2 mM N-methylputrescine as substrate, 34% relative inhibition
N-methyl-1,3-diamonopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 55% relative inhibition
N-methyl-1,3-diamonopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 61% relative inhibition
N-methylbutylamine

-
10 mM with 2 mM N-methylputrescine as substrate, 70% relative inhibition
N-methylbutylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 23% relative inhibition
N-methylbutylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 19% relative inhibition
N-methylpropylamine

-
10 mM with 2 mM N-methylputrescine as substrate, 75% relative inhibition
N-methylpropylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 13% relative inhibition
N-methylpropylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 22% relative inhibition
n-Propylamine

-
10 mM with 2 mM N-methylputrescine as substrate, 28% relative inhibition
n-Propylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 23% relative inhibition
n-Propylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 48% relative inhibition
N6-(3-aminopropyl)adenine

-
noncompetitive
N6-(3-aminopropyl)adenine
-
competitive
N6-(3-aminopropyl)adenine
-
competitive
N6-(4-amino-cis-but-2-enyl)adenine

-
noncompetitive
N6-(4-amino-cis-but-2-enyl)adenine
-
competitive
N6-(4-amino-cis-but-2-enyl)adenine
-
competitive
Na2S2O3

-
0.0033 mM, with 0.01 mM tyramine, 20.7% inhibition
Na2S2O3
-
0.0033 mM, with 0.01 mM tyramine, 21.5% inhibition
Na2S2O3
-
0.0033 mM, with 0.01 mM cadaverine, 18.2% inhibition
NaCN

-
-
NaHSO3

-
0.0033 mM, with 0.01 mM tyramine, 19.5% inhibition
NaHSO3
-
0.0033 mM, with 0.01 mM tyramine, 19.3% inhibition
NaHSO3
-
0.0033 mM, with 0.01 mM cadaverine, 21.1% inhibition
NaN3

-
0.0033 mM, with 0.01 mM tyramine, 82.2% inhibition
NaN3
-
0.0033 mM, with 0.01 mM tyramine, 87.8% inhibition
NaN3
-
0.0033 mM, with 0.01 mM cadaverine, 85.6% inhibition
NaN3
-
uncompetitive vs. p-dimethylaminomethylbenzylamine, N3- is equatorially coordinated to a tetragonal Cu(II) center
o-phenanthroline

-
-
phenylhydrazine

-
10 mM, complete inhibition
phenylhydrazine
1 mM, complete inhibition; 1 mM, complete inhibition
phenylhydrazine
-
69% inhibition at 0.01 mM
Quinacrine

0.1 mM, 73% inhibition; 67% inhibition
Quinacrine
-
1 mM, complete inhibition
Semicarbazide

-
-
Semicarbazide
-
0.1 mM, 99% inhibition, oxidation of histamine
Semicarbazide
-
1 mM, complete inhibition
Semicarbazide
-
57% inhibition at 10 mM
Semicarbazide
very strong inhibition
tranylcypromine

-
-
triethyltetramine

-
-
additional information

-
not inhibited by pargyline
-
additional information
-
the recombinant enzyme is not inhibited by ethanol, acetaldehyde, disulfiram, diethyldithiocarbamate or cyanamide
-
additional information
-
inhibtion by the copper ligand diethyldithiocarbamate and the carbonyl reagents suggests that copper and pyrrroloquinoline are present at the active site of this enzyme; primary amines inhibit pea and pig kidney DAO activities more strongly than the Hyoscyamus niger. N-methylated amines are stronger inhibtors of the Hyoscyamus enzyme than of the others DAOs
-
additional information
-
primary amines inhibit pea and pig kidney DAO activities more strongly than the Hyoscyamus niger. N-methylated amines are stronger inhibtors of the Hyoscyamus enzyme than of the others DAOs
-
additional information
clorgyline and deprenyl do not decrease DAO activity
-
additional information
-
no substrate inhibition with monoamines; substrate inhibition with diamines
-
additional information
alkylamino derivatives of 4-aminomethylpyridine, substrate-like, reversible inhibitors
-
additional information
-
primary amines inhibit pea and pig kidney DAO activities more strongly than the Hyoscyamus niger. N-methylated amines are stronger inhibtors of the Hyoscyamus enzyme than of the others DAOs
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.