1.4.3.22 | histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2 |
a mechanistic proposal for O2 reduction is advanced on the basis of thermodynamic considerations together with kinetic studies, the identification of steady-state intermediates, and the analysis of competitive oxygen kinetic isotope effects. The 18O kinetic isotope effect: 1.0136 at pH 7.2 is independent of temperature from 5°C to 47°C and insignificantly changed to 1.0122 upon raising the pH to 9, thus indicating the absence of kinetic complexity |
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