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EC Number	Metals/Ions	Commentary	Reference
1.4.3.22	Al3+	activates	391945
1.4.3.22	Ca2+	enzmye contains 2 Ca2+-binding sites per subunit	702356
1.4.3.22	Ca2+	tightly bound, proposed to occupy a second metal-binding site	656295
1.4.3.22	Co2+	activates	391945
1.4.3.22	copper	0.063% i.e. 1.5 copper atoms per dimer	391927
1.4.3.22	copper	0.09-0.2 copper atoms per subunit	391953
1.4.3.22	copper	0.5 copper atoms per subunit	391953
1.4.3.22	copper	1.0 gatom of copper per 70000 Da	391931
1.4.3.22	copper	1.5 mol per mol of dimer	656295
1.4.3.22	copper	2 copper atoms per mol of enzyme	391941

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Release 2023.1 (January 2023)