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Literature summary for 1.4.3.22 extracted from

  • Kettner, L.; Seitl, I.; Fischer, L.
    Evaluation of porcine diamine oxidase for the conversion of histamine in food-relevant amounts (2020), J. Food Sci., 85, 843-852 .
    View publication on PubMed
Search for more literature for 1.4.3.22

Application

Application Comment Organism
pharmacology improved food supplements must be developed to help histamine intolerant humans. At least 50 nkat free porcine diamine oxidase are required to convert 75 mg histamine to (imidazol-4-yl)acetaldehyde in an in vitro test system. This results in a reduction of histamine by 90%. The enzyme showes weak stability under simulated intestinal conditions with a half-life period of around 19 min. Therefore, a lot more exogenous diamine oxidase would be required for efficient histamine degradation in the human intestine Sus scrofa

General Stability

General Stability Organism
the enzyme shows weak stability under simulated intestinal conditions with a half-life period of around 19 min Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
histamine substrate inhibition at 0.5 mM Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histamine + H2O + O2 Sus scrofa
-
 (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa Q9TRC7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histamine + H2O + O2
-
 Sus scrofa (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?