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EC 1.14.14.175 Details
show Brenda entryEC number
1.14.14.175
Accepted name
ferruginol synthase
Reaction
abieta-8,11,13-triene + [reduced NADPH—hemoprotein reductase] + O2 = ferruginol + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
miltiradiene oxidase (incorrect),
CYP76AH1,
miltiradiene,NADPH:oxygen oxidoreductase (ferruginol forming) (incorrect)
Systematic name
abieta-8,11,13-triene,[reduced NADPH—hemoprotein reductase]:oxygen 12-oxidoreductase (ferruginol-forming)
Comment
A cytochrome P-450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.
History
created 2014 as EC 1.14.13.190, modified 2015, transferred 2020 to EC 1.14.14.175
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
