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EC 1.14.14.16 Details
show Brenda entryEC number
1.14.14.16
Accepted name
steroid 21-monooxygenase
Reaction
a C21 steroid + [reduced NADPH—hemoprotein reductase] + O2 = a 21-hydroxy-C21-steroid + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
steroid 21-hydroxylase,
21-hydroxylase,
P450c21,
CYP21A2 (gene name)
Systematic name
steroid,NADPH—hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)
CAS registry number
9029-68-9
Comment
A P-450 heme-thiolate protein responsible for the conversion of progesterone and 17α-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. The electron donor is EC 1.6.2.4, NADPH—hemoprotein reductase.
History
created 1961 as EC 1.99.1.11, transferred 1965 to EC 1.14.1.8, transferred 1972 to EC 1.14.99.10, modified 2013, transferred 2015 to EC 1.14.14.16
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
