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EC 1.14.14.33 Details
show Brenda entryEC number
1.14.14.33
Accepted name
ethylenediaminetetraacetate monooxygenase
Reaction
ethylenediaminetetraacetate + 2 FMNH2 + 2 O2 = ethylenediamine-N,N′-diacetate + 2 glyoxylate + 2 FMN + 2 H2O (overall reaction);;(1a) ethylenediaminetetraacetate + FMNH2 + O2 = ethylenediaminetriacetate + glyoxylate + FMN + H2O;;(1b) ethylenediaminetriacetate + FMNH2 + O2 = ethylenediamine-N,N′-diacetate + glyoxylate + FMN + H2O
Systematic name
ethylenediaminetetraacetate,FMNH2:O2 oxidoreductase (glyoxylate-forming)
Comment
The enzyme is part of a two component system that also includes EC 1.5.1.42, FMN reductase (NADH), which provides reduced flavin mononucleotide for this enzyme. It acts on EDTA only when it is complexed with divalent cations such as Mg2+, Zn2+, Mn2+, Co2+, or Cu2+. While the enzyme has a substrate overlap with EC 1.14.14.10, nitrilotriacetate monooxygenase, it has a much wider substrate range, which includes nitrilotriacetate (NTA) and diethylenetriaminepentaacetate (DTPA) in addition to EDTA.
History
created 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
