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EC 1.14.14.24 Details
show Brenda entryEC number
1.14.14.24
Accepted name
vitamin D 25-hydroxylase
Reaction
calciol + O2 + [reduced NADPH—hemoprotein reductase] = calcidiol + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
vitamin D2 25-hydroxylase,
vitamin D3 25-hydroxylase,
CYP2R1
Systematic name
calciol,NADPH—hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)
Comment
A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase.
History
created 2012 as EC 1.14.13.159, transferred 2016 to EC 1.14.14.24
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
