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EC 1.14.14.25 Details
show Brenda entryEC number
1.14.14.25
Accepted name
cholesterol 24-hydroxylase
Reaction
cholesterol + [reduced NADPH—hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3β,24-diol + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
cholesterol 24-monooxygenase,
CYP46,
CYP46A1,
cholesterol 24S-hydroxylase,
cytochrome P450 46A1
Systematic name
cholesterol,NADPH—hemoprotein reductase:oxygen oxidoreductase (24-hydroxylating)
CAS registry number
50812-30-1, 213327-78-7
Comment
A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood—brain barrier whereas cholesterol cannot [3]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase [3].
History
created 2005 as EC 1.14.13.98, transferred 2016 to EC 1.14.14.25
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
