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EC 1.14.14.47 Details
show Brenda entryEC number
1.14.14.47
Accepted name
nitric-oxide synthase (flavodoxin)
Reaction
2 L-arginine + 3 reduced flavodoxin + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H2O (overall reaction);;(1a) 2 L-arginine + 2 reduced flavodoxin + 2 O2 = 2 Nω-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H2O ;;(1b) 2 Nω-hydroxy-L-arginine + reduced flavodoxin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized flavodoxin + 2 H2O
Other name(s)
nitric oxide synthetase (ambiguous),
NO synthase (ambiguous)
Systematic name
L-arginine,reduced-flavodoxin:oxygen oxidoreductase (nitric-oxide-forming)
Comment
Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39).
History
created 2012 as EC 1.14.13.165, transferred 2017 to EC 1.14.14.47
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
