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EC 1.14.14.94 Details
show Brenda entryEC number
1.14.14.94
Accepted name
leukotriene-B4 20-monooxygenase
Reaction
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH—hemoprotein reductase] + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
leukotriene-B4 20-hydroxylase,
leucotriene-B4 ω-hydroxylase,
LTB4 20-hydroxylase,
LTB4 ω-hydroxylase,
CYP4F2 (gene name),
CYP4F3 (gene name)
Systematic name
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating)
CAS registry number
90119-11-2
Comment
A cytochrome P-450 (heme-thiolate) protein found in mammals.
History
created 1989 as EC 1.14.13.30, transferred 2018 to EC 1.14.14.94
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
