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EC 1.14.14.12 Details
show Brenda entryEC number
1.14.14.12
Accepted name
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Reaction
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O
Other name(s)
HsaA
Systematic name
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase
Comment
This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone. It can use either FADH or FMNH2 as flavin cofactor. The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit.
History
created 2011
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.5.1 created 1961, deleted 1965 1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
