6.3.2.17: tetrahydrofolate synthase
This is an abbreviated version!
For detailed information about tetrahydrofolate synthase, go to the full flat file.
Word Map on EC 6.3.2.17
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6.3.2.17
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methotrexate
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antifolate
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thymidylate
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leukemia
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polyglutamylation
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folate-dependent
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ccrf-cem
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one-carbon
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aminopterin
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casei
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glycinamide
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mtx-resistant
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methylenetetrahydrofolate
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monoglutamate
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ddathf
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trimetrexate
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transformylase
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pemetrexed
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raltitrexed
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formyltransferase
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leucovorin
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7-hydroxymethotrexate
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poly-gamma-glutamylation
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5,10-methylenetetrahydrofolate
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pentaglutamate
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5-formyltetrahydrofolate
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garft
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5,10-dideazatetrahydrofolate
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quinazoline
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lometrexol
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tomudex
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folate-based
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methotrexate-resistant
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triglutamate
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tetraglutamate
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dihydropteroate
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monoglutamylated
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analysis
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pteroylmonoglutamate
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medicine
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n10-propargyl-5,8-dideazafolic
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pharmacology
- 6.3.2.17
- methotrexate
- antifolate
- thymidylate
- leukemia
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polyglutamylation
-
folate-dependent
-
ccrf-cem
-
one-carbon
- aminopterin
- casei
- glycinamide
-
mtx-resistant
- methylenetetrahydrofolate
- monoglutamate
-
ddathf
- trimetrexate
-
transformylase
- pemetrexed
- raltitrexed
-
formyltransferase
- leucovorin
- 7-hydroxymethotrexate
-
poly-gamma-glutamylation
- 5,10-methylenetetrahydrofolate
- pentaglutamate
- 5-formyltetrahydrofolate
- garft
- 5,10-dideazatetrahydrofolate
- quinazoline
- lometrexol
- tomudex
-
folate-based
-
methotrexate-resistant
- triglutamate
- tetraglutamate
- dihydropteroate
-
monoglutamylated
- analysis
- pteroylmonoglutamate
- medicine
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n10-propargyl-5,8-dideazafolic
- pharmacology
Reaction
Synonyms
100194131, AtDFB, cFPGS, DHFS/FPGS, dihydrofolate synthase/folylpolyglutamate synthase, eFPGS, Folate polyglutamate synthetase, FolC, folyl-gamma-glutamate synthetase, Folylpoly(.gamma.-glutamate) synthase, Folylpoly-.gamma.-glutamate synthase, Folylpoly-gamma-glutamate synthetase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, Folylpolyglutamate synthase, Folylpolyglutamate synthetase, folylpolyglutamate synthetase 1, Folylpolyglutamyl synthetase, folypoly-gamma-glutamate synthetase, folypolyformyl glutamate synthase, folypolyglutamate synthase, folypolyglutamate synthetase, Formyltetrahydropteroyldiglutamate synthetase, FPGS, FPGS1, FPGS2, GRMZM2G393334, mFGPS, mFPGS, More, MTHFD1L, N10-Formyltetrahydropteroyldiglutamate synthetase, PfDHFS-FPGS, Synthetase, folylpolyglutamate, Tail length regulator, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydrofolylpolyglutamate synthase
ECTree
6.3.2.17 tetrahydrofolate synthaseAdvanced search results
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Localization on EC 6.3.2.17 - tetrahydrofolate synthase
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
the mitochondrial isoform is an integral membrane protein
additional information
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a single gene encodes both, mitochondrial and cytosolic isoforms of the enzyme
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a single gene encodes both, mitochondrial and cytosolic isoforms of the enzyme
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mFGPS is at least in part strongly associated with the inner mitochondrial membrane
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MTHFD1L enzyme is present and functional in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines
additional information
subcellular localization of the three isoforms of FPGS in Arabidopsis thaliana: FPGS1 is localized in plastid, FPGS2 in mitochondria, and FPGS3 in the cytosol
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additional information
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subcellular localization of the three isoforms of FPGS in Arabidopsis thaliana: FPGS1 is localized in plastid, FPGS2 in mitochondria, and FPGS3 in the cytosol
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additional information
folylpoly-gamma-glutamate synthetase resides in both the cytoplasm and mitochondria
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additional information
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two mRNAs for the fpgs gene direct isoforms of FPGS to the cytosol and to mitochondria
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additional information
two mRNAs for the fpgs gene direct isoforms of FPGS to the cytosol and to mitochondria
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additional information
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two mRNAs for the fpgs gene direct isoforms of FPGS to the cytosol and to mitochondria in mouse and human tissues
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additional information
two mRNAs for the fpgs gene direct isoforms of FPGS to the cytosol and to mitochondria in mouse and human tissues
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additional information
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distinct isoforms with different electrophoretic mobility
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additional information
human FPGS (hFPGS) has two major isoforms, the short isoform represents a cytosolic enzyme (cFPGS), while the longer isoform contains a mitochondrial leader sequence (MLS) directing FPGS to mitochondria (mFPGS). The cytosolic fraction contains between 65-75% of total cellular FPGS and the mitochondria 25-35%
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additional information
human FPGS (hFPGS) has two major isoforms, the short isoform represents a cytosolic enzyme (cFPGS), while the longer isoform contains a mitochondrial leader sequence (MLS) directing FPGS to mitochondria (mFPGS). The cytosolic fraction contains between 65-75% of total cellular FPGS and the mitochondria 25-35%
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additional information
human FPGS (hFPGS) has two major isoforms, the short isoform represents a cytosolic enzyme (cFPGS), while the longer isoform contains a mitochondrial leader sequence directing FPGS to mitochondria (mFPGS). The cytosolic fraction contains between 65-75% of total cellular FPGS and the mitochondria 25-35%
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additional information
human FPGS (hFPGS) has two major isoforms, the short isoform represents a cytosolic enzyme (cFPGS), while the longer isoform contains a mitochondrial leader sequence directing FPGS to mitochondria (mFPGS). The cytosolic fraction contains between 65-75% of total cellular FPGS and the mitochondria 25-35%
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additional information
folylpoly-gamma-glutamate synthetase resides in both the cytoplasm and mitochondria. The cytosolic fraction contains between 65-75% of total cellular FPGS and the mitochondria 25-35%
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additional information
folylpoly-gamma-glutamate synthetase resides in both the cytoplasm and mitochondria. The cytosolic fraction contains between 65-75% of total cellular FPGS and the mitochondria 25-35%
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