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ATP + methotrexate + L-glutamate
ADP + phosphate + L-glutamyl-methotrexate
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ATP + tetrahydrofolate-Glu + L-glutamate
ADP + phosphate + tetrahydrofolyl-Glu2
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
additional information
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ATP + tetrahydrofolate-Glu + L-glutamate
ADP + phosphate + tetrahydrofolyl-Glu2
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ATP + tetrahydrofolate-Glu + L-glutamate
ADP + phosphate + tetrahydrofolyl-Glu2
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
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enzyme in biosynthesis of folylpolyglutamates , the most universal functions of folylpolyglutamates: 1. Actual cofactors in vivo for folate dependent enzymes, 2. Inhibitor of folate dependent enzymes for which they are not substrates, 3. Increases retention of folates after they are transported into cells as monoglutamates
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enzyme of folate biosynthetic pathway
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the enzyme catalyzes the MgATP-dependent ligation of L-glutamate to tetrahydrofolate coenzymes or to antifolates at the gamma-carboxyl of the terminal glutamate to form polyglutamate derivatives
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additional information
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enzyme in biosynthesis of folylpolyglutamates , the most universal functions of folylpolyglutamates: 1. Actual cofactors in vivo for folate dependent enzymes, 2. Inhibitor of folate dependent enzymes for which they are not substrates, 3. Increases retention of folates after they are transported into cells as monoglutamates
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mitochondrial enzyme is required for mitochondrial one carbon metabolism and for normal one carbon flux in the cytosol
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enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents
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central enzyme in establishing and maintaining folylpolyglutamate pools in whole cells
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the enzyme catalyzes the formation of an amide bond between glutamic acid and the gamma-carboxyl group of any of the naturally occurring folate compounds
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the enzyme catalyzes the MgATP-dependent addition of glutamate residues to the gamma-carboxyl of folates to generate folylpolyglutamates
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the enzyme synthesizes folate and antifolate poly(gamma-glutamate) metabolites
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folylpoly-gamma-glutamate synthetase can catalyze the processive addition of approximately four glutamate residues to (6R)-5,10-dideaza-5,6,7,8-tetrahydropteroylglutamic acid. The degree of processivity is dependent on the concentration of the folate substrate, thus suggesting a mechanism for the regulation of folate polyglutamate synthesis in cells
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additional information
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the enzyme catalyzes the MgATP-dependent ligation of L-glutamate to tetrahydrofolate coenzymes or to antifolates at the gamma-carboxyl of the terminal glutamate to form polyglutamate derivatives
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additional information
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the enzyme metabolizes tetrahydrofolates to long chain polyglutamates within the cytosol or mitochondria of the cells as a mechanism to trap them within the cell
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the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine
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the enzyme catalyzes the formation of polyglutamates from folates and folate antimetabolites in mammalian cells
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the enzyme metabolizes tetrahydrofolates to long chain polyglutamates within the cytosol or mitochondria of the cells as a mechanism to trap them within the cell
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enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents
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additional information
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the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine
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