6.3.2.17: tetrahydrofolate synthase

This is an abbreviated version!
For detailed information about tetrahydrofolate synthase, go to the full flat file.

Reaction

Synonyms

100194131, AtDFB, cFPGS, DHFS/FPGS, dihydrofolate synthase/folylpolyglutamate synthase, eFPGS, Folate polyglutamate synthetase, FolC, folyl-gamma-glutamate synthetase, Folylpoly(.gamma.-glutamate) synthase, Folylpoly-.gamma.-glutamate synthase, Folylpoly-gamma-glutamate synthetase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, Folylpolyglutamate synthase, Folylpolyglutamate synthetase, folylpolyglutamate synthetase 1, Folylpolyglutamyl synthetase, folypoly-gamma-glutamate synthetase, folypolyformyl glutamate synthase, folypolyglutamate synthase, folypolyglutamate synthetase, Formyltetrahydropteroyldiglutamate synthetase, FPGS, FPGS1, FPGS2, GRMZM2G393334, mFGPS, mFPGS, More, MTHFD1L, N10-Formyltetrahydropteroyldiglutamate synthetase, PfDHFS-FPGS, Synthetase, folylpolyglutamate, Tail length regulator, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydrofolylpolyglutamate synthase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.17 tetrahydrofolate synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
16	Activating Compound
7813	AA Sequence
10	Application
1	CAS Registry Number
46	Cloned(Commentary)
18	Cofactor
6	Crystallization (Commentary)
507	Disease/ Diagnostics
6	Expression
48	General Information
10	General Stability
28	IC50 Value
122	Inhibitors
33	Ki Value [mM]
286	KM Value [mM]
56	Localization
119	Metals/Ions
34	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
155	Organism
5	Pathway
13	PDB ID
30	pH Optimum
5	pH Range
1	Posttranslational Modification
83	Protein Variants
35	Purification (Commentary)
12	Reaction
2	Reaction Type
152	Reference
136	Source Tissue
64	Specific Activity [micromol/min/mg]
17	Storage Stability
481	Substrates and Products (Substrate)
26	Subunits
114	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
35	Turnover Number [1/s]

Systematic Name

print visible entries

print all entries

Systematic Name on EC 6.3.2.17 - tetrahydrofolate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming)

In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.12, dihydrofolate synthase [3], the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates (H4folate). In contrast, the activities are located on separate proteins in most eukaryotes studied to date [4]. In Arabidopsis thaliana, this enzyme is present as distinct isoforms in the mitochondria, the cytosol and the chloroplast. Each isoform is encoded by a separate gene, a situation that is unique among eukaryotes [4]. As the affinity of folate-dependent enzymes increases markedly with the number of glutamic residues, the tetrahydropteroyl polyglutamates are the preferred coenzymes of C1 metabolism. (reviewed in [5]). The enzymes from different sources (particularly eukaryotes versus prokaryotes) have different substrate specificities with regard to one-carbon substituents and the number of glutamate residues present on the tetrahydrofolates.