6.3.2.17: tetrahydrofolate synthase

This is an abbreviated version!
For detailed information about tetrahydrofolate synthase, go to the full flat file.

Word Map on EC 6.3.2.17

6.3.2.17

methotrexate

antifolate

thymidylate

leukemia

polyglutamylation

folate-dependent

ccrf-cem

one-carbon

aminopterin

casei

glycinamide

mtx-resistant

methylenetetrahydrofolate

monoglutamate

ddathf

trimetrexate

transformylase

pemetrexed

raltitrexed

formyltransferase

leucovorin

7-hydroxymethotrexate

poly-gamma-glutamylation

5,10-methylenetetrahydrofolate

pentaglutamate

5-formyltetrahydrofolate

garft

5,10-dideazatetrahydrofolate

quinazoline

lometrexol

tomudex

folate-based

methotrexate-resistant

triglutamate

tetraglutamate

dihydropteroate

monoglutamylated

analysis

pteroylmonoglutamate

medicine

n10-propargyl-5,8-dideazafolic

pharmacology

Reaction

Synonyms

100194131, AtDFB, cFPGS, DHFS/FPGS, dihydrofolate synthase/folylpolyglutamate synthase, eFPGS, Folate polyglutamate synthetase, FolC, folyl-gamma-glutamate synthetase, Folylpoly(.gamma.-glutamate) synthase, Folylpoly-.gamma.-glutamate synthase, Folylpoly-gamma-glutamate synthetase, Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, Folylpolyglutamate synthase, Folylpolyglutamate synthetase, folylpolyglutamate synthetase 1, Folylpolyglutamyl synthetase, folypoly-gamma-glutamate synthetase, folypolyformyl glutamate synthase, folypolyglutamate synthase, folypolyglutamate synthetase, Formyltetrahydropteroyldiglutamate synthetase, FPGS, FPGS1, FPGS2, GRMZM2G393334, mFGPS, mFPGS, More, MTHFD1L, N10-Formyltetrahydropteroyldiglutamate synthetase, PfDHFS-FPGS, Synthetase, folylpolyglutamate, Tail length regulator, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydrofolylpolyglutamate synthase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.17 tetrahydrofolate synthase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
16	Activating Compound
7813	AA Sequence
10	Application
1	CAS Registry Number
46	Cloned(Commentary)
18	Cofactor
6	Crystallization (Commentary)
507	Disease/ Diagnostics
6	Expression
48	General Information
10	General Stability
28	IC50 Value
122	Inhibitors
33	Ki Value [mM]
286	KM Value [mM]
56	Localization
119	Metals/Ions
34	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
155	Organism
5	Pathway
13	PDB ID
30	pH Optimum
5	pH Range
1	Posttranslational Modification
83	Protein Variants
35	Purification (Commentary)
12	Reaction
2	Reaction Type
152	Reference
136	Source Tissue
64	Specific Activity [micromol/min/mg]
17	Storage Stability
481	Substrates and Products (Substrate)
26	Subunits
114	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
35	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

IC50 Value on EC 6.3.2.17 - tetrahydrofolate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to IC50 Value Search

0.000008 - 13

(2S)-2-(o-fluoro-p-(N-(2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)-N-(prop-2-ynyl-amino)benzamido)-4-(tetrazol-5-yl)butyric acid

2 entries

0.0000012

(S)-2(5-(((1,2-dihydro-3-methyl-1-oxobenzo-(f)quinazolin-9-yl)methyl)-1-oxo-2-isoindolinyl))-glutaric acid

Homo sapiens

IC50 of 0.0000009 mM in the wild type cell line, IC50 of 0.0000012 mM to 0.000539 mM in the antifolates-resistant sublines

651536

0.00039

2-[[[(3S)-3-[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]benzoyl)amino]-3-carboxypropyl](hydroxy)phosphoryl]methyl]pentanedioic acid

Plasmodium falciparum

705610

0.000143 - 13

5,10-dideaza-5,6,7,8-tetrahydrofolic acid

2 entries

0.0000095 - 0.0000175

methotrexate

5 entries

0.000001 - 13

methotrexate-Glu

2 entries

0.000008

methotrexate-phosphinate

Homo sapiens

competitive inhibition, IC50 of 0.000008 mM, at fixed substrate and recombinant enzyme concentrations. The most potent FPGS inhibitor based on methotrexate heterocycle. CCRF-CEM R2 subline does not respond to inhibition by this compound at 0.001 mM

649799

0.00012

methotrexate-phosphonate

Homo sapiens

IC50 0.00012 mM, at fixed substrate and recombinant enzyme concentrations

649799

0.000116 - 13

N-(4-(2(2-amino-3,4-dihydro-4-oxo-7H-pyrolo-(2,3-d)pyrimidine-5-yl)ethyl)-benzoyl)-L-glutamic acid

Mus musculus

IC50 of 0.0000136 mM in the wild type cell line, IC50 of 0.000116 mM in the MTA-13 cell line

651536

0.000028 - 13

N-(5-(N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)L-glutamic acid

2 entries

0.000006

Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl-L-ornithine

Homo sapiens

IC50 of 0.000001 mM in the wild type cell line, IC50 of 0.000006 mM to 0.0017 mM in the antifolates-resistant sublines

651536

0.000011 - 0.0000302

pemetrexed

5 entries

additional information

2-[[[(4S)-4-carboxy-4-[(4-[[(2,4-diaminopteridin-6-yl)methyl](methyl)amino]benzoyl)amino]butyl](hydroxy)phosphoryl]methyl]pentanedioic acid

4 entries