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Reference on EC 6.3.2.17 - tetrahydrofolate synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bognar, A.L.; Shane, B.
Bacterial folylpoly(gamma-glutamate) synthase-dihydrofolate synthase
Methods Enzymol.
122
349-359
1986
Corynebacterium sp., Escherichia coli, Lacticaseibacillus casei
Manually annotated by BRENDA team
Bognar, A.L.; Osborne, C.; Shane, B.; Singer, S.C.; Ferone, R.
Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product
J. Biol. Chem.
260
5625-5630
1985
Escherichia coli
Manually annotated by BRENDA team
Shane, B.; Cichowicz, D.J.
Folylpoly-gamma-glutamate synthetases: properties and regulation
Adv. Exp. Med. Biol.
163
149-165
1983
Bacteria, Cricetulus griseus, Corynebacterium sp., Enterococcus faecalis, Lacticaseibacillus casei
Manually annotated by BRENDA team
Clarke, L.; Waxman, D.J.
Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists
Arch. Biochem. Biophys.
256
585-596
1987
Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Clarke, L.; Rosowsky, A.; Waxman, D.J.
Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs
Mol. Pharmacol.
31
122-127
1987
Homo sapiens
Manually annotated by BRENDA team
Cook, J.D.; Cichowicz, D.J.; George, S.; Lawler, A.; Shane, B.
Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis
Biochemistry
26
530-539
1987
Cricetulus griseus, Sus scrofa
Manually annotated by BRENDA team
George, S.; Cichowicz, D.J.; Shane, B.
Mammalian folylpoly-gamma-glutamate synthetase. 3. Specificity of folate analogues
Biochemistry
26
522-529
1987
Sus scrofa
Manually annotated by BRENDA team
Cichowicz, D.J.; Shane, B.
Mammalian folylpoly-gamma-glutamate synthetase. 2. Substrate specificity and kinetic properties
Biochemistry
26
513-521
1987
Sus scrofa
Manually annotated by BRENDA team
Cichowicz, D.J.; Shane, B.
Mammalian folylpoly-gamma-glutamate synthetase. 1. Purification and general properties of the hog liver enzyme
Biochemistry
26
504-512
1987
Sus scrofa
Manually annotated by BRENDA team
Shane, B.
Folylpoly-gamma-glutamate synthetase
Chem. Biol. Pteridines, Proc. Int. Symp. Pteridines Folic Acid Deriv. Chem. Biol. Clin. Aspects
719-728
1986
Corynebacterium sp., Escherichia coli, Lacticaseibacillus casei, Sus scrofa
-
Manually annotated by BRENDA team
Schoo, M.M.J.; Pristupa, Z.B.; Vickers, P.J.; Scrimgeour, K.G.
Folate analogues as substrates of mammalian folylpolyglutamate synthetase
Cancer Res.
45
3034-3041
1985
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Cossins, E.A.; Chan, P.Y.
Folylpolyglutamate synthetase activities of Neurospora
Phytochemistry
23
965-971
1984
Neurospora crassa
-
Manually annotated by BRENDA team
Moran, R.G.; Colman, P.D.
Measurement of folylpolyglutamate synthetase in mammalian tissues
Anal. Biochem.
140
326-342
1984
Cricetulus griseus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Pristupa, Z.B.; Vickers, P.J.; Sephton, G.B.; Scrimgeour, K.G.
Folylpolyglutamate synthetase from beef liver: assay, stabilization, and characterization
Can. J. Biochem. Cell Biol.
62
495-506
1984
Bos taurus
Manually annotated by BRENDA team
McGuire, J.J.; Hsieh, P.; Bertino, J.R.; Coward, J.K.
Studies on the substrate specificity of mammalian folylpolyglutamate synthetase
Chem. Biol. Pteridines, Proc. Int. Symp. Pteridines Folic Acid Deriv. Chem. Biol. Clin. Aspects
615-619
1982
Rattus norvegicus
-
Manually annotated by BRENDA team
Bognar, A.L.; Cichowicz, D.J.; Shane, B.
Purification and characterization of folylpolyglutamate synthetase from Lactobacillus casei and hog liver
Chem. Biol. Pteridines, Proc. Int. Symp. Pteridines Folic Acid Deriv. Chem. Biol. Clin. Aspects
627-632
1982
Lacticaseibacillus casei, Sus scrofa
-
Manually annotated by BRENDA team
Bognar, A.L.; Shane, B.
Purification and properties of Lactobacillus casei folylpoly-gamma-glutamate synthetase
J. Biol. Chem.
258
12574-12581
1983
Lacticaseibacillus casei
Manually annotated by BRENDA team
Moran, R.G.
Characterization of the function of mammalian folylpolyglutamate synthetase (FPGS)
Adv. Exp. Med. Biol.
163
327-339
1983
Mus musculus
Manually annotated by BRENDA team
Shane, B.
Corynebacterium species folylpoly-gamma-glutamate synthetase
Pept. Antibiot. Biosynth. Funct. (Kleinkauf H. et al. eds. )
353-368
1982
Corynebacterium sp.
-
Manually annotated by BRENDA team
Cichowicz, D.J.; Foo, S.K.; Shane, B.
Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells
Mol. Cell. Biochem.
39
209-228
1981
Cricetulus griseus, Corynebacterium sp., Escherichia coli, Enterococcus faecalis, Lacticaseibacillus casei, Neurospora crassa, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
McGuire, J.J.; Bertino, J.R.
Enzymatic synthesis and function of folylpolyglutamates
Mol. Cell. Biochem.
38
19-48
1981
Bacteria, Corynebacterium sp., eukaryota, Neurospora crassa
Manually annotated by BRENDA team
Shane, B.
Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Purification and properties of folylpoly(gamma-glutamate) synthetase
J. Biol. Chem.
255
5655-5662
1980
Corynebacterium sp.
Manually annotated by BRENDA team
Shane, B.
Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Studies on the mechanism of folylpoly(gamma-glutamate) synthetase
J. Biol. Chem.
255
5663-5667
1980
Corynebacterium sp.
Manually annotated by BRENDA team
Bolanowska, W.E.; Russell, C.A.; McGuire, J.J.
Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate
Arch. Biochem. Biophys.
281
198-203
1990
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Moran, R.G.; Colman, P.D.
Mammalian folyl polyglutamate synthetase: Partial purification and properties of the mouse liver enzyme
Biochemistry
23
4580-4589
1984
Mus musculus
Manually annotated by BRENDA team
McDonald, D.; Atkinson, I.J.; Cossins, E.A.; Shane, B.
Isolation of dihydrofolate and folylpolyglutamate synthetase activities from Neurospora
Phytochemistry
38
327-333
1995
Neurospora crassa
Manually annotated by BRENDA team
Pyne, C.; Bognar, A.L.
Replacement of the folC gene, encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli, with genes mutagenized in vitro
J. Bacteriol.
174
1750-1759
1992
Escherichia coli
Manually annotated by BRENDA team
Kimlova, L.J.; Pyne, C.; Keshavjee, K.; Huy, J.; Beebakhee, G.; Bognar, A.L.
Mutagenesis of the folC gene encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli
Arch. Biochem. Biophys.
284
9-16
1991
Escherichia coli
Manually annotated by BRENDA team
Garrow, T.A.; Admon, A.; Shane, B.
Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate)synthetase and determination of its primary structure
Proc. Natl. Acad. Sci. USA
89
9151-9155
1992
Homo sapiens
Manually annotated by BRENDA team
McGuire, J.J.; Bolanowska, W.E.; Piper, J.R.
Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs
Biochem. Pharmacol.
37
3931-3939
1988
Homo sapiens
Manually annotated by BRENDA team
Cody, V.; Luft, J.R.; Pangborn, W.; Toy, J.; Bognar, A.L.
Purification and crystallization of Lactobacillus casei folylpolyglutamate synthetase expressed in Escherichia coli
J. Mol. Biol.
224
1179-1180
1992
Lacticaseibacillus casei
Manually annotated by BRENDA team
Pristupa, Z.B.; McAuley, C.M.; Scrimgeour, K.G.
Folylpolyglutamate synthetase from beef liver: purification and some properties
Biochem. Cell Biol.
69
556-560
1991
Bos taurus
Manually annotated by BRENDA team
Atkinson, I.; Garrow, T.; Brenner, A.; Shane, B.
Human cytosolic folylpoly-gamma-glutamate synthase
Methods Enzymol.
281
134-140
1997
Homo sapiens
Manually annotated by BRENDA team
Imeson, H.C.; Cossins, E.A.
Folylpolyglutamate synthase from higher plants
Methods Enzymol.
281
141-145
1997
Homo sapiens, Pisum sativum
Manually annotated by BRENDA team
Garrow, T.A.; Shane, B.
Purification and general properties of human folylpolyglutamate synthetase
Chem. Biol. Pteridines Folates (J. E. Ayling et al eds. ) Plenum Press New York
659-662
1993
Homo sapiens
Manually annotated by BRENDA team
Shane, B.; Garrow, T.; Brenner, A.; Chen, L.; Choi, Y.J.; Hsu, J.C.; Stover, P.
Folylpoly-gamma-glutamate synthetase
Chem. Biol. Pteridines Folates (J. E. Ayling et al eds. ) Plenum Press New York
629-634
1993
Saccharomyces cerevisiae, Corynebacterium sp., Escherichia coli, eukaryota, Homo sapiens, Lacticaseibacillus casei, Sus scrofa
-
Manually annotated by BRENDA team
Fang, L.; King, J.
Purification and characterization of folylpolyglutamate synthetase (FPGS) from cultured cells of Datura innoxia
J. Plant Physiol.
151
528-534
1997
Datura inoxia
-
Manually annotated by BRENDA team
Imeson, H.C.; Cossins, E.A.
Higher plant folylpolyglutamate synthetase. I. Purification, stability and reaction requirements of the enzyme from pea seedlings
J. Plant Physiol.
138
476-482
1991
Pisum sativum
-
Manually annotated by BRENDA team
Imeson, H.C.; Cossins, E.A.
Higher plant folylpolyglutamate synthetase. II. Some major catalytic properties of the enzyme from Pisum sativum
J. Plant Physiol.
138
483-488
1991
Pisum sativum
-
Manually annotated by BRENDA team
Cossins, E.A.; Chan, P.Y.
An endogenous inhibitor of folylpolyglutamate synthetase in Neurospora crassa
Phytochemistry
27
3391-3399
1988
Bos taurus, Escherichia coli, Neurospora crassa, Pisum sativum
-
Manually annotated by BRENDA team
Chan, P.Y.; Dale, P.L.; Cossins, E.A.
Purification and properties of Neurospora folylpolyglutamate synthetase
Phytochemistry
30
3525-3531
1991
Neurospora crassa
-
Manually annotated by BRENDA team
McGuire, J.J.; Haile, W.H.; Bey, P.; Coward, J.K.
DL-3,3-Difluoroglutamate: an enhancer of folylpolyglutamate elongation
J. Biol. Chem.
265
14073-14079
1990
Rattus norvegicus
Manually annotated by BRENDA team
McGuire, J.J.; Hart, B.P.; Haile, W.H.; Rhee, M.S.; Galivan, J.; Coward, J.K.
DL-beta,beta-Difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(glutamate)synthesis catalyzed by folylpolyglutamate synthetase
Arch. Biochem. Biophys.
321
319-328
1995
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Qi, H.; Atkinson, I.; Xiao, S.; Choi, Y.J.; Tobimatsu, T.; Shane, B.
Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity
Adv. Enzyme Regul.
39
263-273
1999
Homo sapiens
Manually annotated by BRENDA team
DeSouza, L.; Shen, Y.; Bognar, A.L.
Disruption of cytoplasmic and mitochondrial folylpolyglutamate synthetase activity in Saccharomyces cerevisiae
Arch. Biochem. Biophys.
376
299-312
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Sheng, Y.; Cross, J.A.; Shen, Y.; Smith, C.A.; Bognar, A.L.
Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding
Arch. Biochem. Biophys.
402
94-103
2002
Escherichia coli, Lacticaseibacillus casei
Manually annotated by BRENDA team
McGuire, J.J.; Haile, W.H.; Valiaeva, N.; Bartley, D.; Guo, J.; Coward, J.K.
Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate
Biochem. Pharmacol.
65
315-318
2003
Homo sapiens
Manually annotated by BRENDA team
Andreassi, J.L.2nd.; Moran, R.G.
Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors
Biochemistry
41
226-235
2002
Mus musculus
Manually annotated by BRENDA team
Sheng, Y.; Ip, H.; Liu, J.; Davidson, A.; Bognar, A.L.
Binding of ATP as well as tetrahydrofolate induces conformational changes in Lactobacillus casei folylpolyglutamate synthetase in solution
Biochemistry
42
1537-1543
2003
Lacticaseibacillus casei
Manually annotated by BRENDA team
Rots, M.G.; Pieters, R.; Peters, G.J.; Noordhuis, P.; van Zantwijk, C.H.; Kaspers, G.J.; Hahlen, K.; Creutzig, U.; Veerman, A.J.; Jansen, G.
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia
Blood
93
1677-1683
1999
Homo sapiens
Manually annotated by BRENDA team
Turner, F.B.; Andreassi 2nd, J.L.; Ferguson, J.; Titus, S.; Tse, A.; Taylor, S.M.; Moran, R.G.
Tissue-specific expression of functional isoforms of mouse folypoly-gamma-glutamate synthetase: a basis for targeting folate antimetabolites
Cancer Res.
59
6074-6079
1999
Mus musculus
Manually annotated by BRENDA team
Liani, E.; Rothem, L.; Bunni, M.A.; Smith, C.A.; Jansen, G.; Assaraf, Y.G.
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines
Int. J. Cancer
103
587-599
2003
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Sanghani, S.P.; Sanghani, P.C.; Moran, R.G.
Identification of three key active site residues in the C-terminal domain of human recombinant folylpoly-gamma-glutamate synthetase by site-directed mutagenesis
J. Biol. Chem.
274
27018-27027
1999
Homo sapiens
Manually annotated by BRENDA team
McGuire, J.J.; Russell, C.A.; Balinska, M.
Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines
J. Biol. Chem.
275
13012-13016
2000
Homo sapiens
Manually annotated by BRENDA team
Zhao, R.; Titus, S.; Gao, F.; Moran, R.G.; Goldman, I.D.
Molecular analysis of murine leukemia cell lines resistant to 5,10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase
J. Biol. Chem.
275
26599-26606
2000
Mus musculus
Manually annotated by BRENDA team
Sheng, Y.; Sun, X.; Shen, Y.; Bognar, A.L.; Baker, E.N.; Smith, C.A.
Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase
J. Mol. Biol.
302
427-440
2000
Lacticaseibacillus casei (P15925), Lacticaseibacillus casei
Manually annotated by BRENDA team
Sun, X.; Cross, J.A.; Bognar, A.L.; Baker, E.N.; Smith, C.A.
Folate-binding triggers the activation of folylpolyglutamate synthetase
J. Mol. Biol.
310
1067-1078
2001
Lacticaseibacillus casei (P15925), Lacticaseibacillus casei
Manually annotated by BRENDA team
Salcedo, E.; Cortese, J.F.; Plowe, C.V.; Sims, P.F.G.; Hyde, J.E.
A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria
Mol. Biochem. Parasitol.
112
239-252
2001
Plasmodium falciparum
Manually annotated by BRENDA team
Ravanel, S.; Cherest, H.; Jabrin, S.; Grunwald, D.; Surdin-Kerjan, Y.; Douce, R.; Rebeille, F.
Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
98
15360-15365
2001
Arabidopsis thaliana
Manually annotated by BRENDA team
Sanghani, P.C.; Moran, R.G.
Purification and characteristics of recombinant human folylpoly-gamma-glutamate synthetase expressed at high levels in insect cells
Protein Expr. Purif.
18
36-45
2000
Homo sapiens
Manually annotated by BRENDA team
Forsch, R.; Bader, H.; Rosowsky, A.
Synthesis of L-2-(N-pteroylamino)-3-(N-phosphonoacetyl)aminopropanoic acid as an analogue of the putative phosphorylated intermediate in the gamma-glutamation of folic acid by folylpolyglutamate synthetase
Pteridines
10
39-46
1999
Mus musculus, Sus scrofa
-
Manually annotated by BRENDA team
Nair, J.R.; McGuire, J.J.
Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells
Biochim. Biophys. Acta
1746
38-44
2005
Homo sapiens
Manually annotated by BRENDA team
Sohn, K.J.; Smirnakis, F.; Moskovitz, D.N.; Novakovic, P.; Yates, Z.; Lucock, M.; Croxford, R.; Kim, Y.I.
Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate
Gut
53
1825-1831
2004
Homo sapiens
Manually annotated by BRENDA team
Mathieu, M.; Debousker, G.; Vincent, S.; Viviani, F.; Bamas-Jacques, N.; Mikol, V.
Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy
J. Biol. Chem.
280
18916-18922
2005
Escherichia coli
Manually annotated by BRENDA team
Tan, X.J.; Carlson, H.A.
Docking studies and ligand recognition in folylpolyglutamate synthetase
J. Med. Chem.
48
7764-7772
2005
Lacticaseibacillus casei (P15925), Lacticaseibacillus casei
Manually annotated by BRENDA team
Tomsho, J.W.; McGuire, J.J.; Coward, J.K.
Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase
Org. Biomol. Chem.
3
3388-3398
2005
Homo sapiens
Manually annotated by BRENDA team
Smith, C.A.; Cross, J.A.; Bognar, A.L.; Sun, X.
Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops
Acta Crystallogr. Sect. D
62
548-558
2006
Lacticaseibacillus casei (P15925), Lacticaseibacillus casei
Manually annotated by BRENDA team
Young, P.G.; Smith, C.A.; Sun, X.; Baker, E.N.; Metcalf, P.
Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS)
Acta Crystallogr. Sect. F
62
579-582
2006
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Naponelli, V.; Hanson, A.D.; Gregory, J.F.
Improved methods for the preparation of [(3)H]folate polyglutamates: biosynthesis with Lactobacillus casei and enzymatic synthesis with Escherichia coli folylpolyglutamate synthetase
Anal. Biochem.
371
127-134
2007
Escherichia coli
Manually annotated by BRENDA team
Sakamoto, E.; Tsukioka, S.; Oie, S.; Kobunai, T.; Tsujimoto, H.; Sakamoto, K.; Okayama, Y.; Sugimoto, Y.; Oka, T.; Fukushima, M.; Oka, T.
Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity
Biochem. Biophys. Res. Commun.
365
801-807
2007
Homo sapiens
Manually annotated by BRENDA team
Leclerc, G.J.; Leclerc, G.M.; Kinser, T.T.; Barredo, J.C.
Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells
BMC Cancer
6
132
2006
Homo sapiens
Manually annotated by BRENDA team
Leil, T.A.; Endo, C.; Adjei, A.A.; Dy, G.K.; Salavaggione, O.E.; Reid, J.R.; Ames, M.M.; Adjei, A.A.
Identification and characterization of genetic variation in the folylpolyglutamate synthase gene
Cancer Res.
67
8772-8782
2007
Homo sapiens
Manually annotated by BRENDA team
Leclerc, G.J.; York, T.A.; Hsieh-Kinser, T.; Barredo, J.C.
Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line
Leuk. Res.
31
293-299
2007
Homo sapiens
Manually annotated by BRENDA team
Young, P.G.; Smith, C.A.; Metcalf, P.; Baker, E.N.
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP
Acta Crystallogr. Sect. D
D64
745-753
2008
Mycobacterium tuberculosis (O53174), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Sheng, Y.; Khanam, N.; Tsaksis, Y.; Shi, X.M.; Lu, Q.S.; Bognar, A.L.
Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site
Biochemistry
47
2388-2396
2008
Escherichia coli (P08192), Escherichia coli, Lacticaseibacillus casei (P15925), Lacticaseibacillus casei
Manually annotated by BRENDA team
Tomsho, J.W.; Moran, R.G.; Coward, J.K.
Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase
Biochemistry
47
9040-9050
2008
Homo sapiens
Manually annotated by BRENDA team
Nagai, S.; Takenaka, K.; Sonobe, M.; Wada, H.; Tanaka, F.
Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lung cancer cell lines
Chemotherapy
54
166-175
2008
Homo sapiens
Manually annotated by BRENDA team
Wettergren, Y.; Odin, E.; Nilsson, S.; Carlsson, G.; Gustavsson, B.
p161NK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer
Mol. Med.
14
412-421
2008
Homo sapiens
-
Manually annotated by BRENDA team
Kwon, Y.K.; Lu, W.; Melamud, E.; Khanam, N.; Bognar, A.; Rabinowitz, J.D.
A domino effect in antifolate drug action in Escherichia coli
Nat. Chem. Biol.
4
602-608
2008
Escherichia coli
Manually annotated by BRENDA team
McGuire, J.J.; Bartley, D.M.; Tomsho, J.W.; Haile, W.H.; Coward, J.K.
Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate
Arch. Biochem. Biophys.
488
140-145
2009
Homo sapiens
Manually annotated by BRENDA team
Izbicka, E.; Diaz, A.; Streeper, R.; Wick, M.; Campos, D.; Steffen, R.; Saunders, M.
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers
Cancer Chemother. Pharmacol.
64
993-999
2009
Homo sapiens
Manually annotated by BRENDA team
Nannizzi, S.; Veal, G.J.; Giovannetti, E.; Mey, V.; Ricciardi, S.; Ottley, C.J.; Del Tacca, M.; Danesi, R.
Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines
Cancer Chemother. Pharmacol.
66
547 - 558
2009
Homo sapiens
Manually annotated by BRENDA team
Leclerc, G.J.; Mou, C.; Leclerc, G.M.; Mian, A.M.; Barredo, J.C.
Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy
Leukemia
24
552-562
2010
Homo sapiens
Manually annotated by BRENDA team
Wang, P.; Wang, Q.; Yang, Y.; Coward, J.K.; Nzila, A.; Sims, P.F.; Hyde, J.E.
Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition
Mol. Biochem. Parasitol.
172
41-51
2010
Plasmodium falciparum
Manually annotated by BRENDA team
Pike, S.T.; Rajendra, R.; Artzt, K.; Appling, D.R.
Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
J. Biol. Chem.
285
4612-4620
2010
Mus musculus
Manually annotated by BRENDA team
Leclerc, G.J.; Sanderson, C.; Hunger, S.; Devidas, M.; Barredo, J.C.
Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia
Leuk. Res.
34
1601-1609
2010
Homo sapiens
Manually annotated by BRENDA team
Srivastava, A.C.; Ramos-Parra, P.A.; Bedair, M.; Robledo-Hernandez, A.L.; Tang, Y.; Sumner, L.W.; Diaz de la Garza, R.I.; Blancaflor, E.B.
The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis
Plant Physiol.
155
1237-1251
2011
Arabidopsis thaliana
Manually annotated by BRENDA team
Jiang, L.; Liu, Y.; Sun, H.; Han, Y.; Li, J.; Li, C.; Guo, W.; Meng, H.; Li, S.; Fan, Y.; Zhang, C.
The mitochondrial folylpolyglutamate synthetase gene is required for nitrogen utilization during early seedling development in Aarabidopsis
Plant Physiol.
161
971-989
2013
Arabidopsis thaliana (F4J2K2), Arabidopsis thaliana (F4K2A1)
Manually annotated by BRENDA team
Piwkham, D.; Siriboonpiputtana, T.; Beuten, J.; Pakakasama, S.; Gelfond, J.A.; Paisooksantivatana, K.; Tomlinson, G.E.; Rerkamnuaychoke, B.
Mutation screening and association study of the folylpolyglutamate synthetase (FPGS) gene with susceptibility to childhood acute lymphoblastic leukemia
Asian Pac. J. Cancer Prev.
16
4727-4732
2015
Homo sapiens (Q05932), Homo sapiens
Manually annotated by BRENDA team
Meng, H.; Xu, B.; Zhang, C.; Jiang, L.
Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness
Biochem. Biophys. Res. Commun.
482
277-281
2017
Arabidopsis thaliana (F4K2A1), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (F4K2A1)
Manually annotated by BRENDA team
Srivastava, A.C.; Chen, F.; Ray, T.; Pattathil, S.; Pena, M.J.; Avci, U.; Li, H.; Huhman, D.V.; Backe, J.; Urbanowicz, B.; Miller, J.S.; Bedair, M.; Wyman, C.E.; Sumner, L.W.; York, W.S.; Hahn, M.G.; Dixon, R.A.; Blancaflor, E.B.; Tang, Y.
Loss of function of folylpolyglutamate synthetase 1 reduces lignin content and improves cell wall digestibility in Arabidopsis
Biotechnol. Biofuels
8
224
2015
Arabidopsis thaliana (F4K2A1), Arabidopsis thaliana Col-0 (F4K2A1)
Manually annotated by BRENDA team
Raz, S.; Stark, M.; Assaraf, Y.G.
Folylpoly-gamma-glutamate synthetase A key determinant of folate homeostasis and antifolate resistance in cancer
Drug Resist. Updat.
28
43-64
2016
Rattus norvegicus (M0R401), Escherichia coli (P08192), Lacticaseibacillus casei (P15925), Mus musculus (P48760), Homo sapiens (Q05932), Homo sapiens (Q96LE3), Cricetulus griseus (Q924L9)
Manually annotated by BRENDA team
Yang, C.; Xie, L.Y.; Windle, J.J.; Taylor, S.M.; Moran, R.G.
Humanizing mouse folate metabolism conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure
FASEB J.
28
1998-2008
2014
Mus musculus (P48760), Mus musculus
Manually annotated by BRENDA team
Wojtuszkiewicz, A.; Raz, S.; Stark, M.; Assaraf, Y.G.; Jansen, G.; Peters, G.J.; Sonneveld, E.; Kaspers, G.J.; Cloos, J.
Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance
Int. J. Cancer
138
1645-1656
2016
Homo sapiens
Manually annotated by BRENDA team
Lawrence, S.A.; Titus, S.A.; Ferguson, J.; Heineman, A.L.; Taylor, S.M.; Moran, R.G.
Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates
J. Biol. Chem.
289
29386-29396
2014
Cricetulus griseus, Cricetulus griseus (Q924L9)
Manually annotated by BRENDA team
Hashiguchi, M.; Tanaka, T.; Shimizu, M.; Tsuru, T.; Chiyoda, T.; Miyawaki, K.; Irie, S.; Takeuchi, O.; Hakamata, J.; Mochizuki, M.
Sex differences in mRNA expression of reduced folate carrier-1, folypolyformyl glutamate synthase, and gamma-glutamyl hydrolase in a healthy Japanese population
J. Clin. Pharm.
56
1563-1569
2016
Homo sapiens (Q05932), Homo sapiens
Manually annotated by BRENDA team
Kim, S.E.; Hinoue, T.; Kim, M.S.; Sohn, K.J.; Cho, R.C.; Weisenberger, D.J.; Laird, P.W.; Kim, Y.I.
Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells
J. Nutr. Biochem.
29
27-35
2016
Homo sapiens
Manually annotated by BRENDA team
Huang, Z.; Tong, H.F.; Li, Y.; Qian, J.C.; Wang, J.X.; Wang, Z.; Ruan, J.C.
Effect of the polymorphism of folylpolyglutamate synthetase on treatment of high-dose methotrexate in pediatric patients with acute lymphocytic leukemia
Med. Sci. Monit.
22
4967-4973
2016
Homo sapiens
Manually annotated by BRENDA team
Gomez-Gomez, Y.; Organista-Nava, J.; Rangel-Rodriguez, C.A.; Illades-Aguiar, B.; Moreno-Godinez, M.E.; Alarcon-Romero, L.D.; Leyva-Vazquez, M.A.
Effect of folylpolyglutamate synthase A22G polymorphism on the risk and survival of patients with acute lymphoblastic leukemia
Oncol. Lett.
8
731-735
2014
Homo sapiens
Manually annotated by BRENDA team
Li, L.; Hill-Skinner, S.; Liu, S.; Beuchle, D.; Tang, H.M.; Yeh, C.T.; Nettleton, D.; Schnable, P.S.
The maize brown midrib4 (bm4) gene encodes a functional folylpolyglutamate synthase
Plant J.
81
493-504
2015
Zea mays (K7VM84), Zea mays
Manually annotated by BRENDA team
Meng, H.; Jiang, L.; Xu, B.; Guo, W.; Li, J.; Zhu, X.; Qi, X.; Duan, L.; Meng, X.; Fan, Y.; Zhang, C.
Arabidopsis plastidial folylpolyglutamate synthetase is required for seed reserve accumulation and seedling establishment in darkness
PLoS ONE
9
e101905
2014
Arabidopsis thaliana (F4K2A1)
Manually annotated by BRENDA team
Yamamoto, T.; Shikano, K.; Nanki, T.; Kawai, S.
Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis
Sci. Rep.
6
35615
2016
Homo sapiens (Q05932), Homo sapiens
Manually annotated by BRENDA team