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4.98.1.1: protoporphyrin ferrochelatase

This is an abbreviated version!
For detailed information about protoporphyrin ferrochelatase, go to the full flat file.

Word Map on EC 4.98.1.1

Reaction

protoheme
+ 2 H+ =
protoporphyrin
 +
Fe2+

Synonyms

chelatase, ferro-, EC 4.99.1.1, FC1, FC2, FeC, FeCH, ferro-protoporphyrin chelatase, ferrochelatase, ferrochelatase 1, ferrochelatase I, ferrochelatase II, frataxin, HEM15, heme synthase, heme synthetase, hemH, HemH1, HemH2, hFC, host red cell ferrochelatase, iron chelatase, parasite genome-coded ferrochelatase, PfFC, PPIX ferrochelatase, protohaem ferrolyase, protoheme ferro-lyase, protoheme ferrolyase, protoheme lyase, protoporhyrin IX ferrochelatase, protoporphyrin (IX) ferrochelatase, protoporphyrin IX ferrochelatase, Shew_1140, Shew_2229, type II ferrochelatase

ECTree

     4 Lyases
         4.98 ATP-independent chelatases
             4.98.1 Forming coordination complexes
                4.98.1.1 protoporphyrin ferrochelatase

Storage Stability

Storage Stability on EC 4.98.1.1 - protoporphyrin ferrochelatase

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-30°C less loss of activity than under unfrozen conditions
-
18°C, in 20 mM Tris-HCl (pH 8.0) containing 0.3 M NaCl, about 2 weeks, 42% residual activity
-
2 days, 4°C, 20% glycerol, 1 mM dithiothreitol, no loss of activity
-
4°C, in 20 mM Tris-HCl (pH 8.0) containing 0.3 M NaCl, 1 month, no loss of activity
-
membrane-bound enzyme stable to freezing for months, storage at 4°C for at least several weeks, solubilized enzyme labile
-
stable for at 1 month, -25°C, 50% loss of activity, 4°C, 1 week
-
stable for several months, pH 7.8, 70°C
-
t1/2: 12 h, 4°C or 20°C, beta-mercaptoethanol
-
additional information