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4.98.1.1: protoporphyrin ferrochelatase

This is an abbreviated version!
For detailed information about protoporphyrin ferrochelatase, go to the full flat file.

Word Map on EC 4.98.1.1

Reaction

protoheme
+ 2 H+ =
protoporphyrin
 +
Fe2+

Synonyms

chelatase, ferro-, EC 4.99.1.1, FC1, FC2, FeC, FeCH, ferro-protoporphyrin chelatase, ferrochelatase, ferrochelatase 1, ferrochelatase I, ferrochelatase II, frataxin, HEM15, heme synthase, heme synthetase, hemH, HemH1, HemH2, hFC, host red cell ferrochelatase, iron chelatase, parasite genome-coded ferrochelatase, PfFC, PPIX ferrochelatase, protohaem ferrolyase, protoheme ferro-lyase, protoheme ferrolyase, protoheme lyase, protoporhyrin IX ferrochelatase, protoporphyrin (IX) ferrochelatase, protoporphyrin IX ferrochelatase, Shew_1140, Shew_2229, type II ferrochelatase

ECTree

     4 Lyases
         4.98 ATP-independent chelatases
             4.98.1 Forming coordination complexes
                4.98.1.1 protoporphyrin ferrochelatase

Specific Activity

Specific Activity on EC 4.98.1.1 - protoporphyrin ferrochelatase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0015
-
at pH and °C
0.033
R31G, pH 7.6, 30°C, unaerobic conditions
0.041
wild-type, pH 7.6, 30°C, unaerobic conditions
0.054
mutant T302A, pH 7.6, 30°C, unaerobic conditions
0.056
mutant D76G/K102T, pH 7.6, 30°C, unaerobic conditions
0.065
M11V/G104A, pH 7.6, 30°C, unaerobic conditions
0.067
mutant E61K, pH 7.6, 30°C, unaerobic conditions
0.093
E61K/L185Q/G212D, pH 7.6, 30°C, unaerobic conditions
0.413
-
-
0.959
15.2
-
pH 8.0, 37°C
3.08
pH 8.0, 25°C
4.8
presence of cysteine desulfurase NFS1 and small mitochondrial protein ISD11, pH 8.0, 25°C
additional information