4.98.1.1: protoporphyrin ferrochelatase
This is an abbreviated version!
For detailed information about protoporphyrin ferrochelatase, go to the full flat file.
Word Map on EC 4.98.1.1
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4.98.1.1
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ataxia
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friedreich
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protoporphyria
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erythropoietic
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iron-sulfur
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cardiomyopathy
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fe-s
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ferrous
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ala
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photosensitivity
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aconitase
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porphyria
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expansions
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delta-aminolevulinic
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trinucleotide
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triplet
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5-aminolevulinic
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erythroid
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coproporphyrinogen
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iron-binding
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spinocerebellar
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overload
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photodynamic
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hemin
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iscu
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desulfurase
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ferritin
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protoporphyrinogen
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porphobilinogen
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tetrapyrrole
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uroporphyrinogen
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diagnostics
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biotechnology
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griseofulvin
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sideroblast
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coproporphyria
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iron-mediated
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uroporphyrin
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analysis
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dysarthria
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cluster-containing
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phototoxicity
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microcytic
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porphyrinogenic
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deferiprone
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erythroid-specific
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coinheritance
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erythroleukemia
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ala-pdt
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medicine
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idebenone
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deuteroporphyrin
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mesoporphyrin
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delta-aminolaevulinate
- 4.98.1.1
-
ataxia
-
friedreich
-
protoporphyria
-
erythropoietic
-
iron-sulfur
-
cardiomyopathy
- fe-s
-
ferrous
- ala
-
photosensitivity
- aconitase
-
porphyria
-
expansions
-
delta-aminolevulinic
- trinucleotide
-
triplet
-
5-aminolevulinic
-
erythroid
- coproporphyrinogen
-
iron-binding
-
spinocerebellar
-
overload
-
photodynamic
- hemin
- iscu
-
desulfurase
- ferritin
- protoporphyrinogen
- porphobilinogen
- tetrapyrrole
- uroporphyrinogen
- diagnostics
- biotechnology
-
griseofulvin
-
sideroblast
-
coproporphyria
-
iron-mediated
-
uroporphyrin
- analysis
-
dysarthria
-
cluster-containing
-
phototoxicity
-
microcytic
-
porphyrinogenic
- deferiprone
-
erythroid-specific
-
coinheritance
-
erythroleukemia
-
ala-pdt
- medicine
- idebenone
- deuteroporphyrin
- mesoporphyrin
-
delta-aminolaevulinate
Reaction
Synonyms
chelatase, ferro-, EC 4.99.1.1, FC1, FC2, FeC, FeCH, ferro-protoporphyrin chelatase, ferrochelatase, ferrochelatase 1, ferrochelatase I, ferrochelatase II, frataxin, HEM15, heme synthase, heme synthetase, hemH, HemH1, HemH2, hFC, host red cell ferrochelatase, iron chelatase, parasite genome-coded ferrochelatase, PfFC, PPIX ferrochelatase, protohaem ferrolyase, protoheme ferro-lyase, protoheme ferrolyase, protoheme lyase, protoporhyrin IX ferrochelatase, protoporphyrin (IX) ferrochelatase, protoporphyrin IX ferrochelatase, Shew_1140, Shew_2229, type II ferrochelatase
ECTree
4.98.1.1 protoporphyrin ferrochelataseAdvanced search results
results (
results (KCat KM Value
KCat KM Value on EC 4.98.1.1 - protoporphyrin ferrochelatase
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kcat/KM VALUE [1/mMs-1] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
76
deuteroporphyrin IX
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0.5% cholate, for the human ferrochelatase (R115L)-catalyzed insertion of zinc into deuteroporphyrin
1200
deuteroporphyrin IX
-
for the human ferrochelatase (R115L)-catalyzed insertion of zinc into deuteroporphyrin
62.5
Fe2+
-
wild type enzyme, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
179
Fe2+
-
mutant enzyme F323L, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
261.3
Fe2+
-
mutant enzyme S143T/F323L, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
416.8
Fe2+
-
mutant enzyme S143T, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.56
Ni2+
-
wild type enzyme, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
1.605
Ni2+
-
mutant enzyme F323L, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
4.23
Ni2+
-
mutant enzyme S143T/F323L, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
9.05
Ni2+
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mutant enzyme S143T, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
170
protoporphyrin
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in complex with protoporphyrinogen dehydrogenase PgdH1, pH 8.0, 30°C
47.3
protoporphyrin IX
-
wild type enzyme, with Ni2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
82.3
protoporphyrin IX
-
wild type enzyme, with Fe2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
145.7
protoporphyrin IX
-
mutant enzyme S143T, with Fe2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
173.3
protoporphyrin IX
-
mutant enzyme F323L, with Ni2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
180
protoporphyrin IX
-
mutant enzyme S143T/F323L, with Ni2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
292.8
protoporphyrin IX
-
mutant enzyme F323L, with Fe2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
340.5
protoporphyrin IX
-
mutant enzyme S143T/F323L, with Fe2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
2015
protoporphyrin IX
-
mutant enzyme S143T, with Ni2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
2200
Zn2+
-
0.5% cholate, for the human ferrochelatase (R115L)-catalyzed insertion of zinc into deuteroporphyrin
19000
Zn2+
-
for the human ferrochelatase (R115L)-catalyzed insertion of zinc into deuteroporphyrin
