4.98.1.1: protoporphyrin ferrochelatase
This is an abbreviated version!
For detailed information about protoporphyrin ferrochelatase, go to the full flat file.
Word Map on EC 4.98.1.1
-
4.98.1.1
-
ataxia
-
friedreich
-
protoporphyria
-
erythropoietic
-
iron-sulfur
-
cardiomyopathy
-
fe-s
-
ferrous
-
ala
-
photosensitivity
-
aconitase
-
porphyria
-
expansions
-
delta-aminolevulinic
-
trinucleotide
-
triplet
-
5-aminolevulinic
-
erythroid
-
coproporphyrinogen
-
iron-binding
-
spinocerebellar
-
overload
-
photodynamic
-
hemin
-
iscu
-
desulfurase
-
ferritin
-
protoporphyrinogen
-
porphobilinogen
-
tetrapyrrole
-
uroporphyrinogen
-
diagnostics
-
biotechnology
-
griseofulvin
-
sideroblast
-
coproporphyria
-
iron-mediated
-
uroporphyrin
-
analysis
-
dysarthria
-
cluster-containing
-
phototoxicity
-
microcytic
-
porphyrinogenic
-
deferiprone
-
erythroid-specific
-
coinheritance
-
erythroleukemia
-
ala-pdt
-
medicine
-
idebenone
-
deuteroporphyrin
-
mesoporphyrin
-
delta-aminolaevulinate
- 4.98.1.1
-
ataxia
-
friedreich
-
protoporphyria
-
erythropoietic
-
iron-sulfur
-
cardiomyopathy
- fe-s
-
ferrous
- ala
-
photosensitivity
- aconitase
-
porphyria
-
expansions
-
delta-aminolevulinic
- trinucleotide
-
triplet
-
5-aminolevulinic
-
erythroid
- coproporphyrinogen
-
iron-binding
-
spinocerebellar
-
overload
-
photodynamic
- hemin
- iscu
-
desulfurase
- ferritin
- protoporphyrinogen
- porphobilinogen
- tetrapyrrole
- uroporphyrinogen
- diagnostics
- biotechnology
-
griseofulvin
-
sideroblast
-
coproporphyria
-
iron-mediated
-
uroporphyrin
- analysis
-
dysarthria
-
cluster-containing
-
phototoxicity
-
microcytic
-
porphyrinogenic
- deferiprone
-
erythroid-specific
-
coinheritance
-
erythroleukemia
-
ala-pdt
- medicine
- idebenone
- deuteroporphyrin
- mesoporphyrin
-
delta-aminolaevulinate
Reaction
Synonyms
chelatase, ferro-, EC 4.99.1.1, FC1, FC2, FeC, FeCH, ferro-protoporphyrin chelatase, ferrochelatase, ferrochelatase 1, ferrochelatase I, ferrochelatase II, frataxin, HEM15, heme synthase, heme synthetase, hemH, HemH1, HemH2, hFC, host red cell ferrochelatase, iron chelatase, parasite genome-coded ferrochelatase, PfFC, PPIX ferrochelatase, protohaem ferrolyase, protoheme ferro-lyase, protoheme ferrolyase, protoheme lyase, protoporhyrin IX ferrochelatase, protoporphyrin (IX) ferrochelatase, protoporphyrin IX ferrochelatase, Shew_1140, Shew_2229, type II ferrochelatase
ECTree
Advanced search results
KM Value
KM Value on EC 4.98.1.1 - protoporphyrin ferrochelatase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
0.0052
wild type enzyme, in 100 mM tris(hydroxymethyl)aminomethane-HCl, pH 7.4, temperature not specified in the publication
0.56
Co2+
mutant enzyme Y13M, in 100 mM tris(hydroxymethyl)aminomethane-HCl, pH 7.4, temperature not specified in the publication
0.063
wild type enzyme, in 100 mM tris(hydroxymethyl)aminomethane-HCl, pH 7.4, temperature not specified in the publication
0.0026
-
for the human ferrochelatase (R115L)-catalyzed insertion of zinc into deuteroporphyrin
0.0461
deuteroporphyrin IX
-
0.5% cholate, for the human ferrochelatase (R115L)-catalyzed insertion of zinc into deuteroporphyrin
0.05
deuteroporphyrin IX
mutant E272S, in the presence of 4 mM Mg2+, pH 7.4, room temperature
0.00226
Fe2+
-
wild type enzyme, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.00291
Fe2+
-
mutant enzyme S143T, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.0038
Fe2+
-
in complex with protoporphyrinogen dehydrogenase PgdH1, pH 8.0, 30°C
0.00728
Fe2+
-
mutant enzyme S143T/F323L, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.00895
Fe2+
-
mutant enzyme F323L, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.02206
-
wild type enzyme, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.03218
Ni2+
-
mutant enzyme F323L, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.06521
Ni2+
-
mutant enzyme S143T, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.1037
Ni2+
-
mutant enzyme S143T/F323L, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.009
protoporphyrin
-
in complex with protoporphyrinogen dehydrogenase PgdH1, pH 8.0, 30°C
0.00022
wild type enzyme, with Zn2+ as cosubstrate, at pH 8.0 and 30°C
0.00026
protoporphyrin IX
-
wild type enzyme, with Ni2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.00029
protoporphyrin IX
-
mutant enzyme S143T, with Ni2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.0003
protoporphyrin IX
mutant enzyme FeChDELTA347, with Zn2+ as cosubstrate, at pH 8.0 and 30°C
0.00044
protoporphyrin IX
mutant D76G/K102T, pH 7.6, 30°C, unaerobic conditions
0.00078
protoporphyrin IX
mutant E61K, pH 7.6, 30°C, unaerobic conditions
0.00079
protoporphyrin IX
mutant T302A, pH 7.6, 30°C, unaerobic conditions
0.00086
protoporphyrin IX
E61K/L185Q/G212D, pH 7.6, 30°C, unaerobic conditions
0.00091
protoporphyrin IX
wild-type, pH 7.6, 30°C, unaerobic conditions
0.001
protoporphyrin IX
-
wild type enzyme, at pH 8.0, temperature not specified in the publication
0.00123
protoporphyrin IX
-
mutant enzyme F323L, with Ni2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.0013
protoporphyrin IX
M11V/G104A, pH 7.6, 30°C, unaerobic conditions
0.00172
protoporphyrin IX
-
wild type enzyme, with Fe2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.00243
protoporphyrin IX
-
mutant enzyme S143T/F323L, with Ni2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.00251
protoporphyrin IX
mutant P255G, under strictly anaerobic conditions
0.00265
protoporphyrin IX
mutant P255R, under strictly anaerobic conditions
0.005
protoporphyrin IX
-
mutant enzyme F283L, at pH 8.0, temperature not specified in the publication
0.00547
protoporphyrin IX
-
mutant enzyme F323L, with Fe2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.00558
protoporphyrin IX
-
mutant enzyme S143T/F323L, with Fe2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.00684
protoporphyrin IX
mutant S249A/K250Q/V251C, under strictly anaerobic conditions
0.00831
protoporphyrin IX
-
mutant enzyme S143T, with Fe2+ as cosubstrate, 0.1 M Tris-acetate, pH 8.0, 0.5 M NaCl, 0.1% (v/v) Tween 80, at 30°C
0.01034
protoporphyrin IX
mutant Q248P/S249G/K250P/G252W, under strictly anaerobic conditions
0.01125
protoporphyrin IX
mutant K250M/V251L/W256Y, under strictly anaerobic conditions
0.116
protoporphyrin IX
-
mutant enzyme H287L, at pH 8.0, temperature not specified in the publication
0.00017
-
for the human ferrochelatase (R115L)-catalyzed insertion of zinc into deuteroporphyrin
0.0015
Zn2+
-
0.5% cholate, for the human ferrochelatase (R115L)-catalyzed insertion of zinc into deuteroporphyrin
0.024
Zn2+
wild-type, in the presence of 4 mM Mg2+, pH 7.4, room temperature