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4.98.1.1: protoporphyrin ferrochelatase

This is an abbreviated version!
For detailed information about protoporphyrin ferrochelatase, go to the full flat file.

Word Map on EC 4.98.1.1

Reaction

protoheme
+ 2 H+ =
protoporphyrin
+
Fe2+

Synonyms

chelatase, ferro-, EC 4.99.1.1, FC1, FC2, FeC, FeCH, ferro-protoporphyrin chelatase, ferrochelatase, ferrochelatase 1, ferrochelatase I, ferrochelatase II, frataxin, HEM15, heme synthase, heme synthetase, hemH, HemH1, HemH2, hFC, host red cell ferrochelatase, iron chelatase, parasite genome-coded ferrochelatase, PfFC, PPIX ferrochelatase, protohaem ferrolyase, protoheme ferro-lyase, protoheme ferrolyase, protoheme lyase, protoporhyrin IX ferrochelatase, protoporphyrin (IX) ferrochelatase, protoporphyrin IX ferrochelatase, Shew_1140, Shew_2229, type II ferrochelatase

ECTree

     4 Lyases
         4.98 ATP-independent chelatases
             4.98.1 Forming coordination complexes
                4.98.1.1 protoporphyrin ferrochelatase

Expression

Expression on EC 4.98.1.1 - protoporphyrin ferrochelatase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ferrochelatase is light-regulated in a white collar-dependent fashion, ferrochelatase transcript levels are higher after 1 h light exposure when compared with those of the strains grown in the dark
isoform FC2 expression is most effectively stimulated by light (more than 5fold). Isoform FC1 expression is most strongly induced by cycloheximide (more than 8fold) and flagellin (5fold) treatment
-
isoform HemH1 is constitutively expressed. The transcription of HemH1 is regulated by the housekeeping sigma factor RpoD and potentially regulated by OxyR
the transcription of HemH2 is regulated by the oxidative stress-associated sigma factor RpoE2
transcription of the HemH gene is mildly regulated by heme limitation. The presence of nitrate in the medium does not affect HemH expression. Compared to rich medium, minimal salt medium containing acetate, glycerol or succinate as sole sources of carbon and energy induces 1.8-3.2fold increases in HemH expression