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4.98.1.1: protoporphyrin ferrochelatase

This is an abbreviated version!
For detailed information about protoporphyrin ferrochelatase, go to the full flat file.

Word Map on EC 4.98.1.1

Reaction

protoheme
+ 2 H+ =
protoporphyrin
 +
Fe2+

Synonyms

chelatase, ferro-, EC 4.99.1.1, FC1, FC2, FeC, FeCH, ferro-protoporphyrin chelatase, ferrochelatase, ferrochelatase 1, ferrochelatase I, ferrochelatase II, frataxin, HEM15, heme synthase, heme synthetase, hemH, HemH1, HemH2, hFC, host red cell ferrochelatase, iron chelatase, parasite genome-coded ferrochelatase, PfFC, PPIX ferrochelatase, protohaem ferrolyase, protoheme ferro-lyase, protoheme ferrolyase, protoheme lyase, protoporhyrin IX ferrochelatase, protoporphyrin (IX) ferrochelatase, protoporphyrin IX ferrochelatase, Shew_1140, Shew_2229, type II ferrochelatase

ECTree

     4 Lyases
         4.98 ATP-independent chelatases
             4.98.1 Forming coordination complexes
                4.98.1.1 protoporphyrin ferrochelatase

Substrates Products

Substrates Products on EC 4.98.1.1 - protoporphyrin ferrochelatase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-bisacetal deuteroporphyrin + Fe2+
?
show the reaction diagram
-
-
-
-
?
2,4-disulfonic deuteroporphyrin + Fe2+
?
show the reaction diagram
-
-
-
?
Cd2+-protoporphyrin + H+
protoporphyrin + Cd2+
show the reaction diagram
-
poor substrate
-
-
?
Co2+-protoporphyrin + H+
protoporphyrin + Co2+
show the reaction diagram
-
-
-
-
?
deuteroporphyrin + Fe2+
deuteroheme + 2 H+
show the reaction diagram
deuteroporphyrin + Mn2+
? + H+
show the reaction diagram
in contrast to protoporphyrin IX, deuteroporphyrin lacks the vinyl groups at the 2- and 4-ring positions, and therefore, it is possible to structurally discriminate enzyme-bound (metallated) deuteroporphyrin from any possible heme (protoheme) carryover from the enzyme preparation
-
-
?
deuteroporphyrin + Ni2+
? + H+
show the reaction diagram
the Ni-deuteroporphyrin structure is distinctly different from the Mn-deuteroporphyrin model, despite the only variation in enzyme preparation being the addition of either Ni or Mn
-
-
?
deuteroporphyrin IX + Fe2+
iron-deuteroporphyrin IX + H+
show the reaction diagram
-
-
-
-
?
deuteroporphyrin IX + Zn2+
zinc-deuteroporphyrin IX + H+
show the reaction diagram
-
-
-
?
deuteroporphyrin IX + Zn2+
Zn deuteroporphyrin IX + H+
show the reaction diagram
-
in vitro, zinc is the preferred substrate at all concentrations of porphyrin
-
-
?
deuteroporphyrin IX + Zn2+
Zn-deuteroporphyrin IX + H+
show the reaction diagram
Fe2+-2,4-bis-acetal deuteroporphyrin
?
show the reaction diagram
-
-
-
-
?
Fe2+-2,4-diacetyldeuteroporphyrin
?
show the reaction diagram
-
-
-
-
?
Fe2+-2,4-disulfonate deuteroporphyrin
?
show the reaction diagram
-
-
-
-
?
Fe2+-hematoporphyrin
?
show the reaction diagram
Fe2+-mesoporphyrin IX + H+
mesoporphyrin IX + Fe2+
show the reaction diagram
-
-
-
-
?
Fe2+-protoporphyrin + H+
protoporphyrin + Fe2+
show the reaction diagram
-
-
-
-
?
hematoporphyrin + Fe2+
?
show the reaction diagram
-
-
-
-
?
heme + Zn2+
Zn-protoporphyrin + H+
show the reaction diagram
-
-
-
-
?
hemin + H+
mesoporphyrin IX + Zn2+
show the reaction diagram
-
-
-
-
r
hemoglobin + Zn2+
Zn-protoporphyrin + H+
show the reaction diagram
mesoporphyrin + Fe2+
mesoheme
show the reaction diagram
pH 8.0
-
-
?
mesoporphyrin + Fe2+
mesoheme + H+
show the reaction diagram
mesoporphyrin + Zn2+
Zn-mesoporphyrin + 2 H+
show the reaction diagram
mesoporphyrin IX + Co2+
cobalt mesoporphyrin IX + 2 H+
show the reaction diagram
mesoporphyrin IX + Fe2+
?
show the reaction diagram
mesoporphyrin IX + Fe2+
Fe-mesoporphyrin IX + 2 H+
show the reaction diagram
mesoporphyrin IX + Fe2+
iron mesoporphyrin IX + 2 H+
show the reaction diagram
-
-
-
?
mesoporphyrin IX + Fe2+
mesoheme + 2 H+
show the reaction diagram
mesoporphyrin IX + ferrous ammonium sulfate
mesoheme + ammonium sulfate
show the reaction diagram
room temperature
-
-
?
mesoporphyrin IX + Zn2+
zinc mesoporphyrin IX + 2 H+
show the reaction diagram
-
-
-
-
?
mesoporphyrin IX + Zn2+
Zn2+-mesoporphyrin + 2 H+
show the reaction diagram
-
-
-
-
r
myoglobin + Zn2+
Zn-protoporphyrin + H+
show the reaction diagram
N-methyl mesoporphyrin + Cu2+
?
show the reaction diagram
pH 7.4
-
-
?
N-methyl mesoporphyrin + Zn2+
?
show the reaction diagram
pH 7.4
-
-
?
porphyrin + Fe2+
heme + H+
show the reaction diagram
-
-
-
?
porphyrin + metal ion
metalloporphyrin
show the reaction diagram
protoheme + H+
protoporphyrin + Fe2+
show the reaction diagram
protoporphyrin + Cu2+
Cu2+-protoporphyrin + H+
show the reaction diagram
-
-
-
?
protoporphyrin + Fe2+
protoheme + 2 H+
show the reaction diagram
protoporphyrin + Fe2+
protoheme + H+
show the reaction diagram
protoporphyrin + Zn2+
Zn2+-protoporphyrin + H+
show the reaction diagram
protoporphyrin IX + Co2+
?
show the reaction diagram
-
-
-
?
protoporphyrin IX + Co2+
Co2+-protoporphyrin + H+
show the reaction diagram
-
-
-
?
protoporphyrin IX + Cu2+
?
show the reaction diagram
-
-
-
?
protoporphyrin IX + Cu2+
Cu2+-protoporphyrin + H+
show the reaction diagram
Cu2+ is a good substrate
-
-
?
protoporphyrin IX + Fe2+
?
show the reaction diagram
protoporphyrin IX + Fe2+
Fe-protoporphyrin IX + 2 H+
show the reaction diagram
protoporphyrin IX + Fe2+
Fe2+-protoporphyrin IX + 2 H+
show the reaction diagram
-
-
-
-
?
protoporphyrin IX + Fe2+
heme + 2 H+
show the reaction diagram
-
-
-
?
protoporphyrin IX + Fe2+
protoheme + 2 H+
show the reaction diagram
protoporphyrin IX + Fe2+
protoheme IX + 2 H+
show the reaction diagram
protoporphyrin IX + FeCl3
protoheme + HCl
show the reaction diagram
pH 7.5, 37°C
-
-
?
protoporphyrin IX + Ni2+
?
show the reaction diagram
-
-
-
-
?
protoporphyrin IX + Zn2+
?
show the reaction diagram
protoporphyrin IX + Zn2+
Zn protoporphyrin IX
show the reaction diagram
pH 7.4, room temperature
-
-
?
protoporphyrin IX + Zn2+
Zn-protoporphyrin + H+
show the reaction diagram
-
-
-
?
protoporphyrin IX + Zn2+
Zn-protoporphyrin IX
show the reaction diagram
protoporphyrin IX + Zn2+
Zn-protoporphyrin IX + H+
show the reaction diagram
-
-
-
-
?
protoporphyrin IX + Zn2+
Zn2+-protoporphyrin IX + H+
show the reaction diagram
-
-
-
-
?
Sn2+-protoporphyrin + H+
protoporphyrin + Sn2+
show the reaction diagram
-
-
-
-
?
Zn2+-mesoporphyrin + H+
mesoporphyrin + Zn2+
show the reaction diagram
Zn2+-protoporphyrin + H+
protoporphyrin + Zn2+
show the reaction diagram
additional information
?
-