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3.5.1.11: penicillin amidase

This is an abbreviated version!
For detailed information about penicillin amidase, go to the full flat file.

Word Map on EC 3.5.1.11

Reaction

penicillin
+
H2O
=
a carboxylate
 +
6-aminopenicillanate

Synonyms

ACPGA001 PGA, AfPGA, alpha-acylamino-beta-lactam acylhydrolase, amidase, amidohydrolase, ampicillin acylase, AuAAC, benzylpenicillin acylase, BmPGA, Eca3205, KcPGA, maPGA, More, novozym 217, PA, PAC, penicillin acylase, penicillin amidase, Penicillin amidohydrolase, penicillin G acylase, Penicillin G amidase, Penicillin G amidohydrolase, penicillin V acylase, Penicillin V amidase, penicillin-G acylase, PGA, PGA650, PVA, semacylase, Sm-PVA, YxeI

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.11 penicillin amidase

KCat KM Value

KCat KM Value on EC 3.5.1.11 - penicillin amidase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
20 - 500
2-nitro-5-[(phenyl-acetyl)amino]benzoic acid
0.52 - 18.39
2-nitro-5-[(phenylacetyl)amino]-benzoic acid
272
2-phenyl-N-(4-sulfamoylphenyl)acetamide
-
pH 7.0, 25°C
805 - 21000
6-nitro-3-(phenylacetamido)-benzoic acid
0.356 - 19.47
amoxicillin
534.2
amoxycillin
pH 7.4, 37°C, recombinant enzyme
21 - 524.4
ampicillin
1227
carbenicillin
pH 7.4, 37°C, recombinant enzyme
58.2 - 1341
cephalexin
4079
cephaloridine
pH 7.4, 37°C, recombinant enzyme
86 - 5019
cephalothin
0.22 - 8.74
D-hydroxyphenylglycine methyl ester
-
268
ethyl 4-[(phenylacetyl)amino] benzoate
-
pH 7.0, 25°C
360
N,2-diphenylacetamide
-
pH 7.0, 25°C
156
N-(4-acetylphenyl)-2-phenylacetamide
-
pH 7.0, 25°C
250
N-(4-bromophenyl)-2-phenylacetamide
-
pH 7.0, 25°C
212
N-(4-cyanophenyl)-2-phenylacetamide
-
pH 7.0, 25°C
209
N-(4-methoxyphenyl)-2-phenylacetamide
-
pH 7.0, 25°C
314
N-(4-methylphenyl)-2-phenylacetamide
-
pH 7.0, 25°C
159
N-(4-nitrophenyl)-2-phenylacetamide
-
pH 7.0, 25°C
185
N-[4-(methylsulfonyl)phenyl]-2-phenylacetamide
-
pH 7.0, 25°C
17.93
penicillin dihydroF
pH 8.0, 40°C recombinant enzyme
2.4
penicillin F
pH 8.0, 40°C recombinant enzyme
0.0005 - 15000
penicillin G
3.6 - 244.11
penicillin K
0.29 - 1232
Penicillin V