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3.5.1.11: penicillin amidase

This is an abbreviated version!
For detailed information about penicillin amidase, go to the full flat file.

Word Map on EC 3.5.1.11

Reaction

penicillin
+
H2O
=
a carboxylate
 +
6-aminopenicillanate

Synonyms

ACPGA001 PGA, AfPGA, alpha-acylamino-beta-lactam acylhydrolase, amidase, amidohydrolase, ampicillin acylase, AuAAC, benzylpenicillin acylase, BmPGA, Eca3205, KcPGA, maPGA, More, novozym 217, PA, PAC, penicillin acylase, penicillin amidase, Penicillin amidohydrolase, penicillin G acylase, Penicillin G amidase, Penicillin G amidohydrolase, penicillin V acylase, Penicillin V amidase, penicillin-G acylase, PGA, PGA650, PVA, semacylase, Sm-PVA, YxeI

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.11 penicillin amidase

KI Value

KI Value on EC 3.5.1.11 - penicillin amidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.276 - 5.7
(R)-alpha-ethylphenylacetic acid
3.5 - 31
(R)-alpha-hydroxyphenylacetic acid
0.076 - 0.47
(R)-alpha-methylphenylacetic acid
2 - 40
(R)-phenylglycinamide
0.37 - 2.1
(S)-alpha-ethylphenylacetic acid
4.05 - 10
(S)-alpha-hydroxyphenylacetic acid
0.36 - 1.5
(S)-alpha-methylphenylacetic acid
26
6-aminopenicillanate
-
37°C, pH 8.7
5
6-aminopenicillanic acid
-
0.0086
benzothiophene-2-boronic acid
-
pH 7.5, 25°C
11
phenoxyacetic acid
-
0.05 - 2
phenylacetamide
0.03 - 450
phenylacetic acid
additional information
additional information
-
inhibition kinetics, effects of tryptophan and serine modifications by phenylmethylsulfonylfluoride and N-bromosuccinimide, fluorometric studies, overview
-