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3.5.1.11: penicillin amidase

This is an abbreviated version!
For detailed information about penicillin amidase, go to the full flat file.

Word Map on EC 3.5.1.11

Reaction

penicillin
+
H2O
=
a carboxylate
 +
6-aminopenicillanate

Synonyms

ACPGA001 PGA, AfPGA, alpha-acylamino-beta-lactam acylhydrolase, amidase, amidohydrolase, ampicillin acylase, AuAAC, benzylpenicillin acylase, BmPGA, Eca3205, KcPGA, maPGA, More, novozym 217, PA, PAC, penicillin acylase, penicillin amidase, Penicillin amidohydrolase, penicillin G acylase, Penicillin G amidase, Penicillin G amidohydrolase, penicillin V acylase, Penicillin V amidase, penicillin-G acylase, PGA, PGA650, PVA, semacylase, Sm-PVA, YxeI

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.11 penicillin amidase

pH Range

pH Range on EC 3.5.1.11 - penicillin amidase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3 - 10
-
activity range of the immobilized enzyme, profile overview
4
-
more than 40% of maximum activity
4 - 10
4 - 6
pH 4.0: about 40% of maximal activity, pH 6.0: about 35% of maximal activity
5 - 10
5 - 8.5
5.5 - 6.5
6 - 11
6 - 8
-
pH 6.0: about 40% of maximal activity, pH 8.0: about 50% of maximal activity
6.5 - 8.5
7 - 8
the enzyme is active over the pH range 7.0-8.0
7 - 8.5
-
-
7.5 - 9.5
-
rapid decrease in activity when the pH is raised above 9.5 or lowered below 7.5
8 - 11
-
pH 8: about 50% of maximal activity, pH 11: about 60% of maximal activity