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3.4.24.64: mitochondrial processing peptidase

This is an abbreviated version!
For detailed information about mitochondrial processing peptidase, go to the full flat file.

Word Map on EC 3.4.24.64

Reaction

Release of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2 =

Synonyms

Alpha-MPP, Atp23, Beta-MPP, EC 3.4.99.41, General mitochondrial processing peptidase, GPP, HA1523, HPP, Imp1, Imp2, inner membrane peptidase processing enzyme, Mas1, Mas2, Matrix peptidase, Matrix processing peptidase, Matrix processing proteinase, Mitochondrial chelator-sensitive protease, mitochondrial processing peptidase, mitochondrial processing peptidase-alpha protein, mitochondrial processing protease, Mitochondrial protein precursor-processing proteinase, MMP-beta, More, MPP, MPP-alpha, P-52, P-55, PEP, Plsp1, Plsp2, PMPCA, Processing enhancing peptidase, processing enhancing protein, processing peptidase, Proteinase, mitochondrial protein precursor-processing, thylakoidal processing peptidase, TPP, TTHA1264

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.64 mitochondrial processing peptidase

Cloned

Cloned on EC 3.4.24.64 - mitochondrial processing peptidase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
alpha-MPP expressed in soluble monomeric form combined with rat beta-MPP, each subunit gene cloned into an expression vector pTrc99A and transformed into Escherichia coli BL21(DE3)
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beta-MPP combined with yeast alpha-MPP expressed in soluble monomeric form, each subunit gene cloned into an expression vector pTrc99A and transformed into Escherichia coli BL21(DE3)
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cDNA of the precursor form of alpha and beta-MPP expressed in Escherichia coli BL21
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coexpression of both subunits results in functionally active enzyme
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DNA and amino acid sequence determination and analysis, expression in Saccharomyces cerevisiae strain JK9-3da/a
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E73Q alpha/beta complex expressed in Escherichia coli BL21(DE3)
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expressed in Escherichia coli
expressed in Escherichia coli BL21 (DE3)
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expressed in Escherichia coli Rosetta (DE3) pLysS cells
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expression in Escherichia coli
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expression in Escherichia coli BL21 (DE3)
expression of beta subunit of MPP mRNA is down-regulated during early development, the level of the beta subunit of MPP protein is constant throughout the life cycle
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expression of wild-type enzyme and enzyme mutants in DELTA atp23cells
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gene mppA, encoding subunit alpha-MPP, located on chromosome 2, DNA and amino acid sequence determination and analysis, sequence comparisons, expression of alphaMPP237-GFP, a fusion protein in which the N-terminal 237 amino acids of alpha-MPP are fused to GFP. Expression of mppA is developmentally regulated. Overexpression in Dictyostelium, Development of an alpha-mpp antisense strain is delayed, disruption of the mppA gene is lethal in Dictyostelium
Neurospora crassa (alpha-MPP)
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Neurospora crassa (MPP)
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Neurospora crassa and processing enhancing protein subunit
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rat (MPP1 polypeptide)
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rat, alpha- and beta-subunit, expressed in Escherichia coli as fusion proteins with maltose-binding protein
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Saccharomyces cerevisiae
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Saccharomyces cerevisiae (MAS2)
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Saccharomyces cerevisiae (wild-type MAS1)
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sequence comparisons, overview, expression in Escherichia coli strain BL21(DE3)
Solanum tuberosum, subunits I-III
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wild-type and mutant enzyme overexpressed in Escherichia coli BL21(DE3)
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