3.4.24.64: mitochondrial processing peptidase
This is an abbreviated version!
For detailed information about mitochondrial processing peptidase, go to the full flat file.
Reaction
Release of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2
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Synonyms
Alpha-MPP, Atp23, Beta-MPP, EC 3.4.99.41, General mitochondrial processing peptidase, GPP, HA1523, HPP, Imp1, Imp2, inner membrane peptidase processing enzyme, Mas1, Mas2, Matrix peptidase, Matrix processing peptidase, Matrix processing proteinase, Mitochondrial chelator-sensitive protease, mitochondrial processing peptidase, mitochondrial processing peptidase-alpha protein, mitochondrial processing protease, Mitochondrial protein precursor-processing proteinase, MMP-beta, More, MPP, MPP-alpha, P-52, P-55, PEP, Plsp1, Plsp2, PMPCA, Processing enhancing peptidase, processing enhancing protein, processing peptidase, Proteinase, mitochondrial protein precursor-processing, thylakoidal processing peptidase, TPP, TTHA1264
ECTree
Organism
Organism on EC 3.4.24.64 - mitochondrial processing peptidase
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a fungal intracellular microsporidian parasite
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no activity in Encephalitozoon cuniculi
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P10507: mitochondrial-processing peptidase subunit beta (MAS1), P11914: mitochondrial-processing peptidase subunit alpha (MAS2)
SwissProt
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spinach
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UniProt
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UniProt
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ecotype Columbia-0
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bovine
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bovine, beef
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gene mppA encoding alpha-MPP
UniProt
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Q10713: mitochondrial-processing peptidase subunit alpha
SwissProt
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Q10713: mitochondrial-processing peptidase subunit alpha, O75439: mitochondrial-processing peptidase subunit beta
SwissProt
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wild-type strain 74A
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male Sprague-Dawley
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rat
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31314, 31382, 31383, 31384, 31385, 31389, 667383, 669840, 683617, 683664, 708076, 733381, 754677 -
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mutant strains GL-1 (heme-deficient) or D273-10B-1 (rho-)
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overproducing strain VGA
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overproducing strains G10 (MAS1)
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overproducing strains G12 (MAS2), derived from JK9-3D
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P10507: mitochondrial-processing peptidase subunit beta (MAS1), P11914: mitochondrial-processing peptidase subunit alpha (MAS2)
SwissProt
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recombinantly expressed in Escherichia coli
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several strains, overview
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wild-type and mas1-mutants
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wild-type strain AH216 and mas2-mutants
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wild-type strain S288c and derivatives
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yeast
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potato
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potato, var. Bintje
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var. Marfona
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wheat
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additional information
homology between rat, yeast and Neurospora enzymes
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additional information
homology between rat, yeast and Neurospora enzymes
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additional information
MAS1 protein of Saccharomyces cerevisiae is immunologically related to Neurospora crassa MPP
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additional information
the enzymes from Spinacia oleracea or Solanum tuberosum are immunologically not related to MPP but to processing enhancing protein (i.e. PEP) from fungi and mammals
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additional information
the enzymes from Spinacia oleracea or Solanum tuberosum are immunologically not related to MPP but to processing enhancing protein (i.e. PEP) from fungi and mammals
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