3.4.24.64: mitochondrial processing peptidase

This is an abbreviated version!
For detailed information about mitochondrial processing peptidase, go to the full flat file.

Word Map on EC 3.4.24.64

Reaction

Release of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2 =

Synonyms

More, Processing enhancing peptidase, Proteinase, mitochondrial protein precursor-processing, Matrix peptidase, Matrix processing peptidase, Matrix processing proteinase, Mitochondrial protein precursor-processing proteinase, MPP, Mitochondrial chelator-sensitive protease, General mitochondrial processing peptidase, TPP, processing peptidase, Alpha-MPP, Beta-MPP, HA1523, P-52, P-55, PEP, processing enhancing protein, Mas1, Mas2, Plsp1, Atp23, inner membrane peptidase processing enzyme, Imp1, Imp2, mitochondrial processing peptidase, HPP, GPP, TTHA1264, thylakoidal processing peptidase, Plsp2, MPP-alpha, MMP-beta, mitochondrial processing peptidase-alpha protein, PMPCA, mitochondrial processing protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.64 mitochondrial processing peptidase

Engineering

Engineering on EC 3.4.24.64 - mitochondrial processing peptidase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Q190A
-
site-directed mutagenesis
E47A
-
site-directed mutagenesis
D195N
-
site-directed mutagenesis
H60R
-
site-directed mutagenesis
E136A
-
site-directed mutagenesis
E79A
-
site-directed mutagenesis
H56R
-
site-directed mutagenesis
E59Q
-
site-directed mutagenesis
E129A
-
site-directed mutagenesis
E75A
-
site-directed mutagenesis
E75D
-
site-directed mutagenesis
E77A
-
site-directed mutagenesis
E77D
-
site-directed mutagenesis
E79D
-
site-directed mutagenesis
E47D
-
site-directed mutagenesis
E136D
-
site-directed mutagenesis
E139A
-
site-directed mutagenesis
D188A
-
site-directed mutagenesis
E191A
-
site-directed mutagenesis
D195A
-
site-directed mutagenesis
E191D
-
site-directed mutagenesis
E191Q
-
site-directed mutagenesis
D195E
-
site-directed mutagenesis
D324A
-
site-directed mutagenesis
D413A
-
site-directed mutagenesis
E420A/D421A
-
site-directed mutagenesis
E191A/D195A
-
site-directed mutagenesis
E390Q/D391N
-
site-directed mutagenesis
E168Q
-
site-directed mutation in the consensus metal-binding site, the active site residue mutant is proteolytically inactive, but shows processing of the Atp6 subunit of pre-F1FO-ATP synthase
D378N
-
constructed mutant
H167A
-
site-directed mutation in the consensus metal-binding site, the mutant does not show processing of the Atp6 subunit of pre-F1FO-ATP synthase
E353Q
-
constructed mutant
H18A
-
constructed mutant
H171A
-
site-directed mutation in the consensus metal-binding site, the mutant does not show processing of the Atp6 subunit of pre-F1FO-ATP synthase
E177G
-
mutation does not affect enzymatic activity
E217G
-
mutation does not affect enzymatic activity
S20A
-
mutation does not affect enzymatic activity
S84P
-
mutation does not affect enzymatic activity
Q350R
-
mutation does not affect enzymatic activity
E351Q/D352N/E353Q
-
constructed mutant
E377Q/D378N
-
constructed mutant
E197Q/E201Q
-
constructed mutant
E395D
-
constructed mutant
E351Q
-
constructed mutant
D405N/D406N
-
constructed mutant
E377Q
-
constructed mutant
R8A
-
constructed mutant
W481Y
-
mutation has no effect on protein solubility
W481F
-
mutation has no effect on protein solubility
W481H
-
mutation has no effect on protein solubility
delW481-F482
-
mutation has no effect on protein solubility, slightly unstable during long-term storage
W223M
-
mutation leads to an entirely insoluble protein
W223F
-
mutation leads to a nearly entirely insoluble protein
additional information