3.4.24.64: mitochondrial processing peptidase

This is an abbreviated version!
For detailed information about mitochondrial processing peptidase, go to the full flat file.

Reaction

Release of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2 =

Synonyms

Alpha-MPP, Atp23, Beta-MPP, EC 3.4.99.41, General mitochondrial processing peptidase, GPP, HA1523, HPP, Imp1, Imp2, inner membrane peptidase processing enzyme, Mas1, Mas2, Matrix peptidase, Matrix processing peptidase, Matrix processing proteinase, Mitochondrial chelator-sensitive protease, mitochondrial processing peptidase, mitochondrial processing peptidase-alpha protein, mitochondrial processing protease, Mitochondrial protein precursor-processing proteinase, MMP-beta, More, MPP, MPP-alpha, P-52, P-55, PEP, Plsp1, Plsp2, PMPCA, Processing enhancing peptidase, processing enhancing protein, processing peptidase, Proteinase, mitochondrial protein precursor-processing, thylakoidal processing peptidase, TPP, TTHA1264

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.64 mitochondrial processing peptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
1985	AA Sequence
2	Application
1	CAS Registry Number
35	Cloned(Commentary)
4	Crystallization (Commentary)
10	Disease/ Diagnostics
15	General Information
6	General Stability
68	Inhibitors
43	KM Value [mM]
99	Localization
49	Metals/Ions
36	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
105	Organism
32	PDB ID
9	pH Optimum
2	pH Range
3	Posttranslational Modification
63	Protein Variants
39	Purification (Commentary)
10	Reaction
1	Reaction Type
96	Reference
20	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
241	Substrates and Products (Substrate)
43	Subunits
82	Synonyms
9	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
30	Turnover Number [1/s]

Crystallization

print visible entries

print all entries

Crystallization on EC 3.4.24.64 - mitochondrial processing peptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Crystallization (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystalline cytochrome bc1 complex

Bos taurus

-

651890

crystal structure of the beta-MPP-substrate complex

Rattus norvegicus

-

649576

mutant MPP complexed with 2 different synthtic peptide substrates, crystallized by hanging-drop vapor diffusion method, unit cell constants a = 133 A, b = 178 A, c = 201 A, space group P2(1)2(1)2(1)

Saccharomyces cerevisiae

-

653929

purified recombinant SeMet-labeled enzyme, sitting-drop vapor-diffusion method, 0.001 ml of protein solution containing 22.5 mg/ml protein in 20 mM Tris-HCl (pH 8.0), 150 mM NaCl, and 1 mM DTT, are mixed with 0.001 ml of reservoir solution containing 0.15 M DL-malic acid, pH 7.0, 22% PEG 3350, X-ray diffraction structure determination and analysis at 2.29 A resolution

Thermus thermophilus

Q5SIV0

710508