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Literature summary for 3.4.24.64 extracted from

  • Isaya, G.; Kalousek, F.; Fenton, W.A.; Rosenberg, L.E.
    Cleavage of precursors by the mitochondrial processing peptidase requires a compatible mature protein or an intermediate octapeptide (1991), J. Cell Biol., 113, 65-76.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.64

Cloned(Commentary)

Cloned (Comment) Organism
rat Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus
55000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus removes amino-terminal matrix-targeting sequences from imported mitochondrial precursor proteins during or after translocation across mitochondrial membranes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
MPP Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Storage Stability

Storage Stability Organism
-70°C, in HEPES buffer, pH 7.4, in the presence of DTT, at least 6 months Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
F1-ATPase beta-subunit precursor + H2O
-
 Rattus norvegicus F1-ATPase beta-subunit
-
 ?
Methylmalonyl-CoA mutase + H2O from human Rattus norvegicus Methylmalonyl-CoA mutase
-
 ?
mitochondrial malate dehydrogenase precursor + H2O from rat Rattus norvegicus mitochondrial malate dehydrogenase + mitochondrial malate dehydrogenase transit peptide from rat ?
Mitochondrial proteins with artificial precursors + H2O cleavage specificity Rattus norvegicus ?
-
 ?
additional information precursor substrates must be synthesized by translation in a mRNA-dependent in vitro translation system, e.g. nuclease-treated rabbit reticulocyte lysate Rattus norvegicus ?
-
 ?
additional information removes amino-terminal matrix-targeting sequences from imported mitochondrial precursor proteins during or after translocation across mitochondrial membranes Rattus norvegicus ?
-
 ?
Ornithine carbamoyl transferase precursor + H2O EC 2.1.3.3, from human Rattus norvegicus Ornithine carbamoyl transferase intermediate form
-
 ?
Ubiquinol-cytochrome c reductase iron-sulfur subunit precursor + H2O Neurospora crassa enzyme Rattus norvegicus Ubiquinol-cytochrome c reductase iron-sulfur subunit intermediate form from Neurospora ?

Subunits

Subunits Comment Organism
dimer 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus