BRENDA - Enzyme Database show
show all sequences of 3.4.24.64

Microsporidian mitosomes retain elements of the general mitochondrial targeting system

Burri, L.; Williams, B.A.; Bursac, D.; Lithgow, T.; Keeling, P.J.; Proc. Natl. Acad. Sci. USA 103, 15916-15920 (2006)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
DNA and amino acid sequence determination and analysis, expression in Saccharomyces cerevisiae strain JK9-3da/a
Antonospora locustae
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Antonospora locustae
16020
-
mitosome
inner membrane, a tiny double-membrane-bounded reduced mitochondrion, the mitosome has no genome and must import all its proteins from the cytosol, scheme of Imp1 and Imp2 in the microsporidian mitosome, overview
Antonospora locustae
32047
-
additional information
reduced complexity of targeting pathways in microsporidian mitosomes, overview
Antonospora locustae
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
mitochondrial glycerol-3-phosphate dehydrogenase + H2O
Antonospora locustae
-
processed mitochondrial glycerol-3-phosphate dehydrogenase + prepeptide
-
-
?
additional information
Antonospora locustae
mitosomal substrates of the enzyme are processed to mature proteins in Antonospora locustae with a simplified processing complex, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Antonospora locustae
-
a fungal intracellular microsporidian parasite
-
no activity in Encephalitozoon cuniculi
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
mitochondrial glycerol-3-phosphate dehydrogenase + H2O
-
683997
Antonospora locustae
processed mitochondrial glycerol-3-phosphate dehydrogenase + prepeptide
-
-
-
?
mitochondrial glycerol-3-phosphate dehydrogenase + H2O
arginine residue at the -2 position from the MPP cleavage site, a possible processing site is indicated around residue 40, estimated from deletion experiments
683997
Antonospora locustae
processed mitochondrial glycerol-3-phosphate dehydrogenase + prepeptide
-
-
-
?
additional information
mitosomal substrates of the enzyme are processed to mature proteins in Antonospora locustae with a simplified processing complex, overview
683997
Antonospora locustae
?
-
-
-
-
additional information
no activity with the mitochondrial glycerol-3-phosphate dehydrogenase from Encephalitozoon cuniculi
683997
Antonospora locustae
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
DNA and amino acid sequence determination and analysis, expression in Saccharomyces cerevisiae strain JK9-3da/a
Antonospora locustae
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Antonospora locustae
16020
-
mitosome
inner membrane, a tiny double-membrane-bounded reduced mitochondrion, the mitosome has no genome and must import all its proteins from the cytosol, scheme of Imp1 and Imp2 in the microsporidian mitosome, overview
Antonospora locustae
32047
-
additional information
reduced complexity of targeting pathways in microsporidian mitosomes, overview
Antonospora locustae
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
mitochondrial glycerol-3-phosphate dehydrogenase + H2O
Antonospora locustae
-
processed mitochondrial glycerol-3-phosphate dehydrogenase + prepeptide
-
-
?
additional information
Antonospora locustae
mitosomal substrates of the enzyme are processed to mature proteins in Antonospora locustae with a simplified processing complex, overview
?
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
mitochondrial glycerol-3-phosphate dehydrogenase + H2O
-
683997
Antonospora locustae
processed mitochondrial glycerol-3-phosphate dehydrogenase + prepeptide
-
-
-
?
mitochondrial glycerol-3-phosphate dehydrogenase + H2O
arginine residue at the -2 position from the MPP cleavage site, a possible processing site is indicated around residue 40, estimated from deletion experiments
683997
Antonospora locustae
processed mitochondrial glycerol-3-phosphate dehydrogenase + prepeptide
-
-
-
?
additional information
mitosomal substrates of the enzyme are processed to mature proteins in Antonospora locustae with a simplified processing complex, overview
683997
Antonospora locustae
?
-
-
-
-
additional information
no activity with the mitochondrial glycerol-3-phosphate dehydrogenase from Encephalitozoon cuniculi
683997
Antonospora locustae
?
-
-
-
-
Other publictions for EC 3.4.24.64
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733399
Teixeira
Processing peptidases in mitoc ...
Homo sapiens
Biochim. Biophys. Acta
1833
360-370
2013
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1
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733864
Endow
Stable complex formation of th ...
Arabidopsis thaliana
FEBS Lett.
587
2226-2231
2013
-
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2
-
2
1
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1
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1
1
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1
1
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733944
Mach
An advanced system of the mito ...
Trypanosoma brucei
Genome Biol. Evol.
5
860-875
2013
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-
1
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3
1
1
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7
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1
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1
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1
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1
1
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733381
Mossmann
Processing of mitochondrial pr ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1819
1098-1106
2012
-
-
-
-
-
-
-
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1
1
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1
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1
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1
1
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1
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1
1
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733730
Greene
Mitochondrial processing pepti ...
Homo sapiens
EMBO Rep.
13
378-385
2012
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-
1
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1
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1
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1
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1
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1
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1
1
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2
2
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-
734654
Desy
Trypanosoma brucei has a canon ...
Trypanosoma brucei
Mol. Biochem. Parasitol.
185
161-164
2012
-
-
-
-
-
-
-
-
1
1
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1
-
4
-
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1
1
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1
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1
1
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-
734853
Kwasniak
Proteolytic system of plant mi ...
Arabidopsis thaliana
Physiol. Plant.
145
187-195
2012
-
-
-
-
-
-
-
-
1
1
-
1
-
1
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1
1
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1
1
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-
-
709853
Nagayama
Mitochondrial processing pepti ...
Dictyostelium discoideum
Microbiology
156
978-989
2010
-
-
1
-
1
-
-
-
3
-
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1
-
3
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1
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1
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2
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2
2
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708076
Voegtle
Global analysis of the mitocho ...
Saccharomyces cerevisiae
Cell
139
428-439
2009
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1
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1
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1
1
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709066
Naamati
Dual targeting of Nfs1 and dis ...
Saccharomyces cerevisiae
J. BIOL. CHEM.
284
30200-30208
2009
-
-
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-
2
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1
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1
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1
1
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710508
Ohtsuka
Crystal structure of TTHA1264, ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Proteins
75
774-780
2009
-
-
1
1
-
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2
1
2
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3
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1
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2
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2
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1
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2
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1
1
-
-
-
696812
Nagayama
Antisense RNA inhibition of th ...
Dictyostelium discoideum
Biosci. Biotechnol. Biochem.
72
1836-1846
2008
-
-
1
-
-
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1
-
3
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3
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1
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1
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700914
Smid
Reductive evolution of the mit ...
Giardia intestinalis, Trichomonas vaginalis
PLoS Pathog.
4
e1000243
2008
-
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1
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2
1
1
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8
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2
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2
2
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1
1
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2
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2
2
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683617
Nishino
Spatial orientation of mitocho ...
Saccharomyces cerevisiae
J. Biochem.
141
889-895
2007
-
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2
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1
1
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2
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2
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1
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4
1
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2
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1
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4
1
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683664
Mukhopadhyay
Precursor protein is readily d ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
282
37266-37275
2007
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2
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2
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2
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2
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4
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1
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1
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1
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2
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1
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2
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1
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1
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-
683686
Yoon
N-terminal iron-mediated self- ...
Homo sapiens
J. Biol. Inorg. Chem.
12
535-542
2007
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1
1
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2
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683860
Osman
Prohibitins interact genetical ...
Saccharomyces cerevisiae
Mol. Biol. Cell
18
627-635
2007
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1
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4
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1
1
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2
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669160
Nomura
Identification and reverse gen ...
Brugia malayi, Caenorhabditis elegans
J. Biochem.
139
967-979
2006
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2
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683997
Burri
Microsporidian mitosomes retai ...
Antonospora locustae, no activity in Encephalitozoon cuniculi
Proc. Natl. Acad. Sci. USA
103
15916-15920
2006
-
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1
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3
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2
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9
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4
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667491
Oshima
Recognition and processing of ...
Saccharomyces cerevisiae
Biochem. J.
385
755-761
2005
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667383
Janata
Substrate evokes translocation ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
316
211-217
2004
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6
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1
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1
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6
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1
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669838
Rudhe
Processing of the dual targete ...
Solanum tuberosum
J. Mol. Biol.
343
639-647
2004
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The bifunctional cytochrome c ...
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Characterization of the bifunc ...
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Functional reconstitution in E ...
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31398
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Mitochondrial processing prote ...
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The MAS-encoded processing pro ...
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The general mitochondrial matr ...
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Mitochondrial protein import: ...
Neurospora crassa
Cell
53
795-806
1988
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31389
Yang
Import of proteins into yeast ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae D-273-10B
EMBO J.
7
3857-3862
1988
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12
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31390
Jensen
Import of proteins into yeast ...
Saccharomyces cerevisiae
EMBO J.
7
3863-3871
1988
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31391
Witte
MAS1, a gene essential for yea ...
More, Saccharomyces cerevisiae
EMBO J.
7
1439-1447
1988
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31386
Miura
A metalloprotease involved in ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
134
1151-1159
1986
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8
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31387
Kumamoto
Characterization of a mitochon ...
Bos taurus, Rattus norvegicus
J. Biochem.
100
247-254
1986
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6
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31383
Bhni
Processing of mitochondrial po ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae D-273-10B
Methods Enzymol.
97
311-323
1983
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31384
McAda
A yeast mitochondrial chelator ...
Saccharomyces cerevisiae
Methods Enzymol.
97
337-344
1983
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31385
Bhni
Import of proteins into mitoch ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae D-273-10B
J. Biol. Chem.
258
4937-4943
1983
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