1.5.1.30: flavin reductase (NADPH)

This is an abbreviated version!
For detailed information about flavin reductase (NADPH), go to the full flat file.

Word Map on EC 1.5.1.30

Reaction

reduced riboflavin
+
NADP+
=
riboflavin
+
NADPH
+
H+

Synonyms

alkanesulfonate FMN reductase, ArsH, azoreductase, AZRü, Biliverdin-IX beta-reductase, CysJ, flavin oxidoreductase, flavin reductase, flavin reductase 1, flavin reductase Nr1, flavin reductase P, FLR, FR1, Frb, Frd188, frd2, fre, Fre oxidoreductase, Fre-1, FRG/FRaseI, FRGvf, FRP, FRPvh, GHBP, Green heme binding protein, HpaC, ipa-43d, More, NAD(P)H-dependent H2O2-forming flavin reductase, NADPH-dependant FMN reductase, NADPH-dependent diaphorase, NADPH-flavin oxidoreductase, NADPH-flavin reductase, NADPH-FMN oxidoreductase, NADPH-FMN reductase, NADPH-nitrofurazone reductase, NADPH-specific flavin reductase, NADPH:FAD oxidoreductase, NADPH:flavin oxidoreductase, NADPH:FMN oxidoreductase, NfrA1, nitro/flavin reductase, non-luminescent-bacterial NfsA/Frp-type enzyme, SsuE, TVAG_517010

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.30 flavin reductase (NADPH)

Reference

Reference on EC 1.5.1.30 - flavin reductase (NADPH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yubisui, T.; Matsuki, T.; Takeshita, M.; Yoneyama, Y.
Characterization of the purified NADPH-flavin reductase of human erythrocytes
J. Biochem.
85
719-728
1979
Homo sapiens
Manually annotated by BRENDA team
Tang, C.K.; Jeffers, C.E.; Nichols, J.C.; Tu, S.C.
Flavin specificity and subunit interaction of Vibrio fischeri general NAD(P)H-flavin oxidoreductase FRG/FRase I
Arch. Biochem. Biophys.
392
110-116
2001
Aliivibrio fischeri
Manually annotated by BRENDA team
Lo, H.S.; Reeves, R.E.
Purification and properties of NADPH: flavin oxidoreductase from Entamoeba histolytica
Mol. Biochem. Parasitol.
2
23-30
1980
Entamoeba histolytica, Entamoeba histolytica NIH:200
Manually annotated by BRENDA team
Lei, B.; Liu, M.; Huang, S.; Tu, S.C.
Vibrio harveyi NADPH-flavin oxidoreductase: cloning, sequencing and overexpression of the gene and purification and characterization of the cloned enzyme
J. Bacteriol.
176
3552-3558
1994
Vibrio harveyi, Vibrio harveyi MAV / ATCC 33843
Manually annotated by BRENDA team
Mack, C.P.; Hultquist, D.E.; Shlafer, M.
Myocardial flavin reductase and riboflavin: a potential role in decreasing reoxygenation injury
Biochem. Biophys. Res. Commun.
212
35-40
1995
Oryctolagus cuniculus
Manually annotated by BRENDA team
Tanner, J.J.; Lei, B.; Tu, S.C.; Krause, K.L.
Flavin reductase P: structure of a dimeric enzyme that reduces flavin
Biochemistry
35
13531-13539
1996
Vibrio harveyi
Manually annotated by BRENDA team
Liu, M.; Lei, B.; Ding, Q.; Lee, J.C.; Tu, S.C.
Vibrio harveyi NADPH:FMN oxidoreductase: preparation and characterization of the apoenzyme and monomer-dimer equilibrium
Arch. Biochem. Biophys.
337
89-95
1997
Vibrio harveyi
Manually annotated by BRENDA team
Parry, R.J.; Li, W.
An NADPH:FAD oxidoreductase from the valanimycin producer, Streptomyces viridifaciens. Cloning analysis, and overexpression
J. Biol. Chem.
272
23303-23311
1997
Streptomyces viridifaciens
Manually annotated by BRENDA team
Zenno, S.; Kobori, T.; Tanokura, M.; Saigo, K.
Purification and characterization of NfrA1, a Bacillus subtilis nitro/flavin reductase capable of interacting with the bacterial luciferase
Biosci. Biotechnol. Biochem.
62
1978-1987
1998
Bacillus subtilis, Bacillus subtilis ISW 1214.
Manually annotated by BRENDA team
Wang, H.; Lei, B.; Tu, S.C.
Vibrio harveyi NADPH-FMN oxidoreductase Arg203 as a critical residue for NADPH recognition and binding
Biochemistry
39
7813-7819
2000
Vibrio harveyi
Manually annotated by BRENDA team
Matsubara, T.; Ohshiro, T.; Nishina, Y.; Izumi, Y.
Purification, characterization, and overexpression of flavin reductase involved in dibenzothiophene desulfurization by Rhodococcus erythropolis D-1
Appl. Environ. Microbiol.
67
1179-1184
2001
Rhodococcus erythropolis, Rhodococcus erythropolis D1
Manually annotated by BRENDA team
Gao, B.; Ellis, H.R.
Altered mechanism of the alkanesulfonate FMN reductase with the monooxygenase enzyme
Biochem. Biophys. Res. Commun.
331
1137-1145
2005
Escherichia coli
Manually annotated by BRENDA team
Lei, B.; Wang, H.; Yu, Y.; Tu, S.C.
Redox potential and equilibria in the reductive half-reaction of Vibrio harveyi NADPH-FMN oxidoreductase
Biochemistry
44
261-267
2005
Aliivibrio fischeri, Vibrio harveyi
Manually annotated by BRENDA team
Kwasnicka, D.A.; Krakowiak, A.; Thacker, C.; Brenner, C.; Vincent, S.R.
Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1
J. Biol. Chem.
278
39051-39058
2003
Caenorhabditis elegans, Homo sapiens, Homo sapiens (Q9UHB4)
Manually annotated by BRENDA team
Low, J.C.; Tu, S.C.
Energy transfer evidence for in vitro and in vivo complexes of Vibrio harveyi flavin reductase P and luciferase
Photochem. Photobiol.
77
446-452
2003
Vibrio harveyi
Manually annotated by BRENDA team
Gao, B.; Bertrand, A.; Boles, W.H.; Ellis, H.R.; Mallett, T.C.
Crystallization and preliminary X-ray crystallographic studies of the alkanesulfonate FMN reductase from Escherichia coli
Acta Crystallogr. Sect. F
F61
837-840
2005
Escherichia coli
Manually annotated by BRENDA team
Li, X.; Tu, S.C.
Activity coupling of Vibrio harveyi luciferase and flavin reductase (FRP): oxygen as a probe
Arch. Biochem. Biophys.
454
26-31
2006
Vibrio harveyi
Manually annotated by BRENDA team
Li, X.; Chow, D.C.; Tu, S.C.
Thermodynamic analysis of the binding of oxidized and reduced FMN cofactor to Vibrio harveyi NADPH-FMN oxidoreductase FRP apoenzyme
Biochemistry
45
14781-14787
2006
Vibrio harveyi
Manually annotated by BRENDA team
Deller, S.; Sollner, S.; Trenker-El-Toukhy, R.; Jelesarov, I.; Guebitz, G.M.; Macheroux, P.
Characterization of a thermostable NADPH:FMN oxidoreductase from the mesophilic bacterium Bacillus subtilis
Biochemistry
45
7083-7091
2006
Bacillus subtilis
Manually annotated by BRENDA team
Okai, M.; Kudo, N.; Lee, W.C.; Kamo, M.; Nagata, K.; Tanokura, M.
Crystal structures of the short-chain flavin reductase HpaC from Sulfolobus tokodaii strain 7 in its three states: NAD(P)(+)-free, NAD(+)-bound, and NADP(+)-bound
Biochemistry
45
5103-5110
2006
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7
Manually annotated by BRENDA team
Liu, G.; Zhou, J.; Lv, H.; Xiang, X.; Wang, J.; Zhou, M.; Qv, Y.
Azoreductase from Rhodobacter sphaeroides AS1.1737 is a flavodoxin that also functions as nitroreductase and flavin mononucleotide reductase
Appl. Microbiol. Biotechnol.
76
1271-1279
2007
Rhodobacter sphaeroides, Rhodobacter sphaeroides AS1.1737
Manually annotated by BRENDA team
Jawanda, N.; Ebalunode, J.; Gribenko, A.; Briggs, J.; Lee, J.C.; Tu, S.C.
A single-residue mutation destabilizes Vibrio harveyi flavin reductase FRP dimer
Arch. Biochem. Biophys.
472
51-57
2008
Vibrio harveyi
Manually annotated by BRENDA team
Jawanda, N.; Ahmed, K.; Tu, S.C.
Vibrio harveyi flavin reductase-luciferase fusion protein mimics a single-component bifunctional monooxygenase
Biochemistry
47
368-377
2008
Vibrio harveyi
Manually annotated by BRENDA team
Tu, S.C.
Activity coupling and complex formation between bacterial luciferase and flavin reductases
Photochem. Photobiol. Sci.
7
183-188
2008
Aliivibrio fischeri, Vibrio harveyi
Manually annotated by BRENDA team
Vorontsov, I.I.; Minasov, G.; Brunzelle, J.S.; Shuvalova, L.; Kiryukhina, O.; Collart, F.R.; Anderson, W.F.
Crystal structure of an apo form of Shigella flexneri ArsH protein with an NADPH-dependent FMN reductase activity
Protein Sci.
16
2483-2490
2007
Shigella flexneri
Manually annotated by BRENDA team
Campbell, Z.T.; Baldwin, T.O.
Fre Is the Major Flavin Reductase Supporting Bioluminescence from Vibrio harveyi Luciferase in Escherichia coli
J. Biol. Chem.
284
8322-8328
2009
Escherichia coli
Manually annotated by BRENDA team
Takahashi, S.; Furuya, T.; Ishii, Y.; Kino, K.; Kirimura, K.
Characterization of a flavin reductase from a thermophilic dibenzothiophene-desulfurizing bacterium, Bacillus subtilis WU-S2B
J. Biosci. Bioeng.
107
38-41
2009
Bacillus subtilis, Bacillus subtilis WU-S2B
Manually annotated by BRENDA team
Chikuba, K.; Yubisui, T.; Shirabe, K.; Takeshita, M.
Cloning and nucleotide sequence of a cDNA of the human erythrocyte NADPH-flavin reductase
Biochem. Biophys. Res. Commun.
198
1170-1176
1994
Homo sapiens, Homo sapiens (P30043)
Manually annotated by BRENDA team
Yubisui, T.; Tamura, M.; Takeshita, M.
Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes
Biochem. Int.
15
1-8
1987
Homo sapiens
Manually annotated by BRENDA team
Shalloe, F.; Elliott, G.; Ennis, O.; Mantle, T.J.
Evidence that biliverdin-IX beta reductase and flavin reductase are identical
Biochem. J.
316
385-387
1996
Bos taurus
Manually annotated by BRENDA team
Cunningham, O.; Gore, M.G.; Mantle, T.J.
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B)
Biochem. J.
345
393-399
2000
Homo sapiens, Homo sapiens (P30043)
Manually annotated by BRENDA team
Chung, H.W.; Tu, S.C.
Structure-function relationship of Vibrio harveyi NADPH-flavin oxidoreductase FRP: essential residues Lys167 and Arg15 for NADPH binding
Biochemistry
51
4880-4887
2012
Vibrio harveyi
Manually annotated by BRENDA team
Haynes, R.K.; Cheu, K.W.; Tang, M.M.; Chen, M.J.; Guo, Z.F.; Guo, Z.H.; Coghi, P.; Monti, D.
Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified
ChemMedChem
6
279-291
2011
Escherichia coli
Manually annotated by BRENDA team
Kozmin, S.G.; Wang, J.; Schaaper, R.M.
Role for CysJ flavin reductase in molybdenum cofactor-dependent resistance of Escherichia coli to 6-N-hydroxylaminopurine
J. Bacteriol.
192
2026-2033
2010
Escherichia coli
Manually annotated by BRENDA team
Zenno, S.; Kobori, T.; Tanokura, M.; Saigo, K.
Purification and characetrizatio of NfrA1, a Bacillus subtilis nitro/flavin reductase capable of interacting with the bacterial luciferase
Biosci. Biotechnol. Biochem.
62
1978-1987
1998
Bacillus subtilis, Bacillus subtilis ISW 1214
Manually annotated by BRENDA team
Man, Z.; Rao, Z.; Xu, M.; Guo, J.; Yang, T.; Zhang, X.; Xu, Z.
Improvement of the intracellular environment for enhancing L-arginine production of Corynebacterium glutamicum by inactivation of H2O2-forming flavin reductases and optimization of ATP supply
Metab. Eng.
38
310-321
2016
Corynebacterium crenatum, Corynebacterium crenatum SYPA5-5
Manually annotated by BRENDA team
Leitsch, D.; Janssen, B.; Kolarich, D.; Johnson, P.; Duchene, M.
Trichomonas vaginalis flavin reductase 1 and its role in metronidazole resistance
Mol. Microbiol.
91
198-208
2014
Trichomonas vaginalis (A2GH85), Trichomonas vaginalis, Trichomonas vaginalis G3 (A2GH85)
Manually annotated by BRENDA team