1.5.1.30: flavin reductase (NADPH)

This is an abbreviated version!
For detailed information about flavin reductase (NADPH), go to the full flat file.

Word Map on EC 1.5.1.30

Reaction

reduced riboflavin
+
NADP+
=
riboflavin
+
NADPH
+
H+

Synonyms

alkanesulfonate FMN reductase, ArsH, azoreductase, AZRü, Biliverdin-IX beta-reductase, CysJ, flavin oxidoreductase, flavin reductase, flavin reductase 1, flavin reductase Nr1, flavin reductase P, FLR, FR1, Frb, Frd188, frd2, fre, Fre oxidoreductase, Fre-1, FRG/FRaseI, FRGvf, FRP, FRPvh, GHBP, Green heme binding protein, HpaC, ipa-43d, More, NAD(P)H-dependent H2O2-forming flavin reductase, NADPH-dependant FMN reductase, NADPH-dependent diaphorase, NADPH-flavin oxidoreductase, NADPH-flavin reductase, NADPH-FMN oxidoreductase, NADPH-FMN reductase, NADPH-nitrofurazone reductase, NADPH-specific flavin reductase, NADPH:FAD oxidoreductase, NADPH:flavin oxidoreductase, NADPH:FMN oxidoreductase, NfrA1, nitro/flavin reductase, non-luminescent-bacterial NfsA/Frp-type enzyme, SsuE, TVAG_517010

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.30 flavin reductase (NADPH)

Inhibitors

Inhibitors on EC 1.5.1.30 - flavin reductase (NADPH)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
2,3-diphosphoglycerate
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
with 0.1 mM 28.8% activity
7-hydroxycoumarin
-
-
acrinol
-
-
AgNO3
-
with 1 mM 1.05% activity
Amaranth
-
the presence of 50 mM amaranth reduces the NADPH oxidation rate 2.6fold
Bathocuproine sulfonate
-
-
Cibacron Marine
-
azo dye, competitive to NADPH and FMN
CuCl2
-
with 1 mM 11.2% activity
HgCl2
lumichrome
competitive inhibitor against FMN and a mixed inhibitor of NADPH
mesobiliverdin XIIIa
competitive kinetics with FMN and mixed inhibition kinetics with NADPH
N-ethylmaleimide
-
with 1 mM 16.3% activity
NADP+
NEM
-
when the enzyme is preincubated with NEM and NADH in the absence of FMN
p-chloromercuribenzoic acid
PCMB
-
-
Ponceau BS
-
the presence of 50 mM Ponceau BS reduces the NADPH oxidation rate 3.7fold
proflavin hemisulfate
-
-
riboflavin
FR1 inhibition by possibly either by the semiquinone or the fully reduced form
SeO32-
-
-
Zn2+
-
-
additional information
-
with 1 mM ethylenediaminetetraacetic acid 99.8% activity, with 1 mM 2,2'-bipyridyl 81.8% activity
-