2.4.2.9: uracil phosphoribosyltransferase

This is an abbreviated version!
For detailed information about uracil phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.9

2.4.2.9

5-fluorouracil

pyrimidine

salvage

5-fluorocytosine

suicide

prodrug

orotate

bystander

5-fluorouridine

oncolytic

markerless

phosphoribosyltransferases

counterselectable

flucytosine

4-thiouracil

medicine

virotherapy

cd/5-fc

gene-directed

synthesis

analysis

molecular biology

pharmacology

Reaction

Synonyms

AFR052C, AFR052Cp, AGOS_AFR052C, AgUPRT, CD-UPRT, cytosine deaminase-uracil phosphoribosyltransferase, cytosine deaminase/uracil phosphoribosyltransferase, More, MtUPRT, phosphoribosyltransferase, uracil, Rv3309c, TtUPRT, TtUPRT3, UK/UPRT1, UMP pyrophosphorylase, UMP:pyrophosphate phosphoribosyltransferase, UPP, UPRT, UPRTase, uracil phosphoribosyl transferase, uridine 5'-phosphate pyrophosphorylase, uridine kinase-like protein (uracil phosphoribosyltransferase), uridine kinase/uracil phosphoribosyltransferase 1, uridine monophosphate pyrophosphorylase, uridylate pyrophosphorylase, uridylic pyrophosphorylase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.9 uracil phosphoribosyltransferase

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Results	in table
22	Activating Compound
44618	AA Sequence
15	Application
1	CAS Registry Number
34	Cloned(Commentary)
7	Crystallization (Commentary)
312	Disease/ Diagnostics
24	General Information
10	General Stability
1	IC50 Value
49	Inhibitors
5	Ki Value [mM]
46	KM Value [mM]
4	Localization
43	Metals/Ions
33	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
368	Organism
5	Pathway
104	PDB ID
21	pH Optimum
7	pH Range
2	pI Value
20	Protein Variants
21	Purification (Commentary)
10	Reaction
1	Reaction Type
66	Reference
30	Source Tissue
19	Specific Activity [micromol/min/mg]
12	Storage Stability
109	Substrates and Products (Substrate)
36	Subunits
88	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
2	Temperature Range [°C]
14	Temperature Stability [°C]
8	Turnover Number [1/s]

Purification

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Purification on EC 2.4.2.9 - uracil phosphoribosyltransferase

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6 entries

DEAE Sepharose column chromatography, Mono Q column chromatography, and Sephacryl S-300 gel filtration

Mycobacterium tuberculosis

737104

from strain SO 1346

Escherichia coli

638362

MonoQ column chromatography and Superdex 200 gel filtration

Mycobacterium tuberculosis

P9WFF3

735615

Ni-NTA affinity column chromatography

Homo sapiens

Q96BW1

675195

Ni-NTA column chromatography

Leishmania donovani

736431

only partial, due to the labile nature of the enzyme further purification is unsuccessful

Candida albicans

638366

partial

2 entries

recombinant enzyme from Escherichia coli, cleavage of the TrxA fusion protein with TEV protease

Eremothecium gossypii

Q754M0

759853

recombinant from enzyme-deficient Escherichia coli

[Bacillus] caldolyticus

P70881

638370

recombinant from Escherichia coli

2 entries

recombinant from overexpressing strain

Escherichia coli

638369

recombinant His6-tagged enzyme from Escherichia coli strain M15 by nickel affinity chromatography

Homo sapiens

Q96BW1

675195

recombinant wild-type and mutant P131D from overexpressing Escherichia coli

Escherichia coli

638372