2.4.2.9: uracil phosphoribosyltransferase

This is an abbreviated version!
For detailed information about uracil phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

AFR052C, AFR052Cp, AGOS_AFR052C, AgUPRT, CD-UPRT, cytosine deaminase-uracil phosphoribosyltransferase, cytosine deaminase/uracil phosphoribosyltransferase, More, MtUPRT, phosphoribosyltransferase, uracil, Rv3309c, TtUPRT, TtUPRT3, UK/UPRT1, UMP pyrophosphorylase, UMP:pyrophosphate phosphoribosyltransferase, UPP, UPRT, UPRTase, uracil phosphoribosyl transferase, uridine 5'-phosphate pyrophosphorylase, uridine kinase-like protein (uracil phosphoribosyltransferase), uridine kinase/uracil phosphoribosyltransferase 1, uridine monophosphate pyrophosphorylase, uridylate pyrophosphorylase, uridylic pyrophosphorylase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.9 uracil phosphoribosyltransferase

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Results	in table
22	Activating Compound
44618	AA Sequence
15	Application
1	CAS Registry Number
34	Cloned(Commentary)
7	Crystallization (Commentary)
312	Disease/ Diagnostics
24	General Information
10	General Stability
1	IC50 Value
49	Inhibitors
5	Ki Value [mM]
46	KM Value [mM]
4	Localization
43	Metals/Ions
33	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
368	Organism
5	Pathway
104	PDB ID
21	pH Optimum
7	pH Range
2	pI Value
20	Protein Variants
21	Purification (Commentary)
10	Reaction
1	Reaction Type
66	Reference
30	Source Tissue
19	Specific Activity [micromol/min/mg]
12	Storage Stability
109	Substrates and Products (Substrate)
36	Subunits
88	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
2	Temperature Range [°C]
14	Temperature Stability [°C]
8	Turnover Number [1/s]

General Stability

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General Stability on EC 2.4.2.9 - uracil phosphoribosyltransferase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

1 mM DTT and 0.1 mM EDTA stabilize the purified enzyme

Giardia intestinalis

-

638368

2-mercaptoethanol, not essential for stability in long-term storage

Escherichia coli

-

638362

bovine serum albumin at 2 mg/ml stabilizes

[Bacillus] caldolyticus

P70881

638370

dialysis against buffers of low ionic strength invariably results in complete inactivation, whereas after 3 h dialysis against 0.5 M KCl only 40% of the activity is lost

Lactobacillus bifidus

-

638358

enzyme is extremly unstable, UMP stabilizes during storage

Candida albicans

-

638366

enzyme is highly unstable, dimethyl sulfoxide stabilizes during purification

Saccharomyces cerevisiae

-

638365

ethylene glycol, significantly increases stability with virtually no loss of activity after storage at 4°C for 13 days or after 1 year at -70°C

Escherichia coli

-

638362

GTP, 5 mM with 10 mM Tris-HCl, pH 7.5, 10 mM MgCl2, 2 mM 2-mercaptoethanol, labilizes with only 15% activity remaining after 13 days, labilizing effect abolished in presence of 5-phospho-alpha-D-ribose 1-diphosphate

Escherichia coli

-

638362

rapid precipitation of purified enzyme without thiol reducing agents

Toxoplasma gondii

-

638367

UMP stabilizes the enzyme

Acholeplasma laidlawii

-

638363