2.4.2.9: uracil phosphoribosyltransferase
This is an abbreviated version!
For detailed information about uracil phosphoribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.9
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2.4.2.9
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5-fluorouracil
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pyrimidine
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salvage
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5-fluorocytosine
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suicide
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prodrug
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orotate
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bystander
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5-fluorouridine
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oncolytic
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markerless
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phosphoribosyltransferases
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counterselectable
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flucytosine
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4-thiouracil
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medicine
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virotherapy
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cd/5-fc
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gene-directed
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synthesis
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analysis
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molecular biology
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pharmacology
- 2.4.2.9
- 5-fluorouracil
- pyrimidine
-
salvage
- 5-fluorocytosine
-
suicide
-
prodrug
- orotate
-
bystander
- 5-fluorouridine
-
oncolytic
-
markerless
-
phosphoribosyltransferases
-
counterselectable
-
flucytosine
- 4-thiouracil
- medicine
-
virotherapy
-
cd/5-fc
-
gene-directed
- synthesis
- analysis
- molecular biology
- pharmacology
Reaction
Synonyms
AFR052C, AFR052Cp, AGOS_AFR052C, AgUPRT, CD-UPRT, cytosine deaminase-uracil phosphoribosyltransferase, cytosine deaminase/uracil phosphoribosyltransferase, More, MtUPRT, phosphoribosyltransferase, uracil, Rv3309c, TtUPRT, TtUPRT3, UK/UPRT1, UMP pyrophosphorylase, UMP:pyrophosphate phosphoribosyltransferase, UPP, UPRT, UPRTase, uracil phosphoribosyl transferase, uridine 5'-phosphate pyrophosphorylase, uridine kinase-like protein (uracil phosphoribosyltransferase), uridine kinase/uracil phosphoribosyltransferase 1, uridine monophosphate pyrophosphorylase, uridylate pyrophosphorylase, uridylic pyrophosphorylase
ECTree
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Reaction
Reaction on EC 2.4.2.9 - uracil phosphoribosyltransferase
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ping-pong reaction mechanism
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UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
sequential reaction mechanism
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UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
sequential reaction mechanism
UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
modelling of enzyme-5-phospho-alpha-D-ribose 1-diphosphate complex
UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
Pro131 is of little importance for 5-phospho-alpha-D-ribose 1-diphosphate binding, but critical for binding of uracil to the enzyme-5-phospho-alpha-D-ribose 1-diphosphate complex
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UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
ping pong steady state kinetic pattern, ordered bi-bi mechanism, model, no formation of the phosphoribosyl-enzyme intermediate predicted by classic ping pong kinetics
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UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
active sites pointing away from each other, a long arm from each monomer subunit wraps around the other subunit
UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
rapid-random equilibrium mechanism
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UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
rapid-random equilibrium mechanism
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