2.3.1.37: 5-aminolevulinate synthase

This is an abbreviated version!
For detailed information about 5-aminolevulinate synthase, go to the full flat file.

Reaction

Synonyms

5-ALA synthase, 5-ALAS, 5-aminolevulinate synthase, 5-aminolevulinate synthetase, 5-aminolevulinic acid synthase, 5-aminolevulinic acid synthetase, ALA, ALA synthase, ALA synthetase, ALA-S, ALAS, ALAS2, alpha-aminolevulinic acid synthase, aminolevulinate synthase, aminolevulinate synthase 2, aminolevulinate synthetase, aminolevulinic acid synthase, aminolevulinic acid synthase 2, aminolevulinic acid synthetase, aminolevulinic synthetase, delta-ALAS, delta-aminolevulinate synthase, delta-aminolevulinate synthetase, delta-aminolevulinic acid synthase, delta-aminolevulinic acid synthase 2, delta-aminolevulinic acid synthetase, delta-aminolevulinic synthetase, erythroid 5-aminolevulinate synthase, erythroid-specific 5-aminolevulinate synthase, Hem1, hemA, HemT, mALAS-2, sigma-aminolevulinate synthase, synthase, aminolevulinate, synthetase, aminolevulinate

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.37 5-aminolevulinate synthase

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Results	in table
34	Activating Compound
9466	AA Sequence
14	Application
1	CAS Registry Number
44	Cloned(Commentary)
117	Cofactor
2	Crystallization (Commentary)
765	Disease/ Diagnostics
17	Expression
23	General Information
14	General Stability
244	Inhibitors
83	kcat/KM [mM/s]
10	Ki Value [mM]
226	KM Value [mM]
53	Localization
17	Metals/Ions
74	Molecular Weight [Da]
80	Natural Substrates/ Products (Substrates)
337	Organism
1	Oxidation Stability
8	Pathway
76	PDB ID
31	pH Optimum
4	pH Range
3	pH Stability
4	Posttranslational Modification
100	Protein Variants
47	Purification (Commentary)
49	Reaction
13	Reaction Type
156	Reference
1	Renatured (Commentary)
109	Source Tissue
45	Specific Activity [micromol/min/mg]
17	Storage Stability
220	Substrates and Products (Substrate)
45	Subunits
104	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
15	Temperature Stability [°C]
90	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.3.1.37 - 5-aminolevulinate synthase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-allyl-2-isopropylacetamide

3 entries

Activator protein

2 entries

-

ATP

2 entries

Butyric acid

Mus musculus

-

induction of enzyme expression, erythroleukemia cells

486847

carbamazepine

Rattus norvegicus

-

-

757560

ClpX

Homo sapiens

-

the mitochondrial AAA+ unfoldase ClpX participates in both heme-dependent degradation of the enzyme and its activation

758234

-

CoA

Solanum tuberosum

-

activates

486809

Dimethylsulfoxide

Mus musculus

-

induction of enzyme expression, erythroleukemia cells

486847

dithiothreitol

Cereibacter sphaeroides

-

activates

486811

EDTA

Cereibacter sphaeroides

-

required

486842

estrogen

Rattus norvegicus

-

-

757560

ethanol

Rattus norvegicus

-

-

757560

ethinylestradiol

Rattus norvegicus

-

-

757560

hexamethylene diacetamide

Mus musculus

-

induction of enzyme expression, erythroleukemia cells

486847

Lubrol

Rattus norvegicus

-

activates, fetal enzyme

486841

-

NaCl

Rattus norvegicus

-

required for maximal activity

486812

native activator protein

2 entries

-

norethandrolone

Rattus norvegicus

-

-

757560

Norethindrone

Rattus norvegicus

-

-

757560

O2

Mus musculus

-

1%, 3fold increase in expression level, promotor activation in transiently transfected HeLa cells, hypoxia-inducible erythroid-isoform

486846

Phenobarbitone

Rattus norvegicus

-

-

757560

Phenylbutazone

Rattus norvegicus

-

-

757560

phosphate

Rhodospirillum rubrum

-

enzyme is maximally active in presence of 0.005 mM phosphate

486817

vitamin B12

2 entries

additional information

2 entries

-

2-allyl-2-isopropylacetamide

Cavia porcellus

-

strong induction of enzyme in liver

486820

2-allyl-2-isopropylacetamide

Gallus gallus

-

strong induction of enzyme in liver

486820, 486850

2-allyl-2-isopropylacetamide

Rattus norvegicus

-

strong induction of enzyme in liver

486820, 486850

Activator protein

Cereibacter sphaeroides

-

from Rhodopseudomonas sphaeroides

486830

-

Activator protein

Rattus norvegicus

-

from rat liver mitochondria possibly activates by formation of high molecular weight aggregates of delta-aminolevulinic acid synthetase

486822

-

ATP

Rattus norvegicus

-

slight activation, erythroid-specific isoform

486848

ATP

Solanum tuberosum

-

activates in assays with crude enzyme extracts

486809

native activator protein

Cereibacter sphaeroides

-

purified from cell extract

486830

-

native activator protein

Rattus norvegicus

-

purified from hepatic extract

486822

-

vitamin B12

Cereibacter sphaeroides

-

stimulates

486839

vitamin B12

Serratia plymuthica

-

stimulates

486839

additional information

Mus musculus

-

iron depletion does not increase isoform II promotor activity

486846

-

additional information

Rhodopseudomonas palustris

-

1-2 low molecular-weight compounds which stimulate or stabilize activity found by dialysis of crude extract

486815

-