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2.3.1.37: 5-aminolevulinate synthase

This is an abbreviated version!
For detailed information about 5-aminolevulinate synthase, go to the full flat file.

Word Map on EC 2.3.1.37

Reaction

succinyl-CoA
+
glycine
=
5-aminolevulinate
 +
CoA
 +
CO2

Synonyms

5-ALA synthase, 5-ALAS, 5-aminolevulinate synthase, 5-aminolevulinate synthetase, 5-aminolevulinic acid synthase, 5-aminolevulinic acid synthetase, ALA, ALA synthase, ALA synthetase, ALA-S, ALAS, ALAS2, alpha-aminolevulinic acid synthase, aminolevulinate synthase, aminolevulinate synthase 2, aminolevulinate synthetase, aminolevulinic acid synthase, aminolevulinic acid synthase 2, aminolevulinic acid synthetase, aminolevulinic synthetase, delta-ALAS, delta-aminolevulinate synthase, delta-aminolevulinate synthetase, delta-aminolevulinic acid synthase, delta-aminolevulinic acid synthase 2, delta-aminolevulinic acid synthetase, delta-aminolevulinic synthetase, erythroid 5-aminolevulinate synthase, erythroid-specific 5-aminolevulinate synthase, Hem1, hemA, HemT, mALAS-2, sigma-aminolevulinate synthase, synthase, aminolevulinate, synthetase, aminolevulinate

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.37 5-aminolevulinate synthase

Storage Stability

Storage Stability on EC 2.3.1.37 - 5-aminolevulinate synthase

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-15°C, 0.1 mM pyridoxal 5'-phosphate, 10% glycerol, 20% loss of activity after 6 weeks
-
-15°C, 20 mM potassium phosphate buffer, pH 7.6, 1 mM dithioerythritol, 0.01 mM pyridoxal 5'-phosphate, 30% loss of activity after 2 weeks
-
-15°C, 50 mM phosphate buffer, pH 6.8, 10% glycerol, 1 mM 2-mercaptoethanol, stable for several months
-
-15°C, loss of 25% activity within 10 days
-
-15°C, not stable
-
-195°C, following an initial loss of 20% of activity due to freeze-thawing the enzyme loses no further activity for at least 6 months
-20°C, 20% loss of activity after 1 month
-
-30°C, complete loss of activity overnight
-
0-4°C, 18 h stable
-
4°C, 20 mM potassium phosphate buffer, pH 7.6, 1 mM dithioerythritol, 0.01 mM pyridoxal 5'-phosphate, 20% loss of activity after 2 weeks
-
4°C, 30 min, 50% loss of apoenzyme of Protaminobacter ruber
-
4°C, 50 mM phosphate buffer, pH 6.8, 10% glycerol, 1 mM 2-mercaptoethanol, 10% loss of activity after 2 weeks
-
4°C, 50 mM Tris-HCl, 100 mM glycine, 0.1 mM pyridoxal 5'-phosphate, 1 mM dithioerythritol, pH 7.6, 5 mM 5'-AMP, stable for at least 4 months
4°C, loss of 40% activity within 10 days
-
5°C, 50 mM phosphate buffer, pH 7.2, 10 mM 2-mercaptoethanol, 20% loss of activity after 1 week
-