2.3.1.37: 5-aminolevulinate synthase
This is an abbreviated version!
For detailed information about 5-aminolevulinate synthase, go to the full flat file.
Word Map on EC 2.3.1.37
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2.3.1.37
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heme
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porphyria
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sideroblastic
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oxygenase
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anemia
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x-linked
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ferrochelatase
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hemoglobin
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marrow
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porphobilinogen
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dehydratase
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pyridoxal
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uroporphyrinogen
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protoporphyria
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iron-responsive
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hemoprotein
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erythroblast
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phenobarbital
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erythropoietic
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tetrapyrrole
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rhodopseudomonas
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rhodobacter
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microcytic
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porphyrinogenic
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erythroleukemia
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delta-aminolaevulinate
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allylisopropylacetamide
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uroporphyrin
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medicine
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synthesis
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hypochromic
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pharmacology
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gata1
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aip
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hexachlorobenzene
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plp-dependent
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cutanea
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5'-phosphate-dependent
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phenobarbital-induced
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biotechnology
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neurovisceral
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nutrition
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rate-controlling
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pyrrolase
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protoporphyrinogen
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heme-mediated
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tarda
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5-aminolaevulinate
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succinyl-coenzyme
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bacteriochlorophyll
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coproporphyrinogen
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agriculture
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harderian
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succinylacetone
- 2.3.1.37
- heme
- porphyria
-
sideroblastic
- oxygenase
- anemia
-
x-linked
-
ferrochelatase
- hemoglobin
- marrow
- porphobilinogen
- dehydratase
- pyridoxal
- uroporphyrinogen
- protoporphyria
-
iron-responsive
- hemoprotein
- erythroblast
- phenobarbital
-
erythropoietic
- tetrapyrrole
- rhodopseudomonas
- rhodobacter
-
microcytic
-
porphyrinogenic
- erythroleukemia
-
delta-aminolaevulinate
-
allylisopropylacetamide
-
uroporphyrin
- medicine
- synthesis
-
hypochromic
- pharmacology
- gata1
- aip
- hexachlorobenzene
-
plp-dependent
-
cutanea
-
5'-phosphate-dependent
-
phenobarbital-induced
- biotechnology
-
neurovisceral
- nutrition
-
rate-controlling
-
pyrrolase
- protoporphyrinogen
-
heme-mediated
- tarda
-
5-aminolaevulinate
-
succinyl-coenzyme
- bacteriochlorophyll
- coproporphyrinogen
- agriculture
-
harderian
- succinylacetone
Reaction
Synonyms
5-ALA synthase, 5-ALAS, 5-aminolevulinate synthase, 5-aminolevulinate synthetase, 5-aminolevulinic acid synthase, 5-aminolevulinic acid synthetase, ALA, ALA synthase, ALA synthetase, ALA-S, ALAS, ALAS2, alpha-aminolevulinic acid synthase, aminolevulinate synthase, aminolevulinate synthase 2, aminolevulinate synthetase, aminolevulinic acid synthase, aminolevulinic acid synthase 2, aminolevulinic acid synthetase, aminolevulinic synthetase, delta-ALAS, delta-aminolevulinate synthase, delta-aminolevulinate synthetase, delta-aminolevulinic acid synthase, delta-aminolevulinic acid synthase 2, delta-aminolevulinic acid synthetase, delta-aminolevulinic synthetase, erythroid 5-aminolevulinate synthase, erythroid-specific 5-aminolevulinate synthase, Hem1, hemA, HemT, mALAS-2, sigma-aminolevulinate synthase, synthase, aminolevulinate, synthetase, aminolevulinate
ECTree
2.3.1.37 5-aminolevulinate synthaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 2.3.1.37 - 5-aminolevulinate synthase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
Xalas2 expression is observed in the aortic arch near the heart and posterior condylar vein
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ALA-S activity is induced by acute administration of anaesthetics (89%), veronal (240%), and ethanol (80). ALA-S mRNA expression augmented by chronic administration of eflurane, allylisopropylacetamide and veronal
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including submandibular and parotid glands, high expression of ALAS1
sodium butyrate treatment activates ALAS2 gene transcription
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rapid stimulation of ALA-s mRNA by ACTH which acts through cyclic AMP
additional information
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high activity in cells grown anaerobically in defined medium, low in cells grown in an iron-deficient medium and in cells grown aerobically
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enzyme in erythrocytes is genetically distinct from that in other tissue
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erythroid induction cultures of CD34+ hematopoietic stem/progenitor cells
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increased activity of ALA synthase which is the rate-limiting enzyme of heme biosynthesis, in the liver of the fatigued animals
additional information
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enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
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enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
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enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
-
enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
-
enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
-
enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
-
enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
-
enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
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infusion of rats with ACTH for 1 h caused an increase of adrenal ALA-s mRNA and activity
additional information
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enzyme is synthezised in the cytosol as the precursor protein and then imported into the mitochondria matrix and cleaved to the mature enzyme, the targeting information is encoded in nonoverlapping regions of the presequence
additional information
the enzyme is first expressed in primitive erythroid cells during primary hematopoiesis before transcription of embryonic globin and is not detected in the dorsolateral plate during secondary hematopoiesis
additional information
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the enzyme is first expressed in primitive erythroid cells during primary hematopoiesis before transcription of embryonic globin and is not detected in the dorsolateral plate during secondary hematopoiesis
