Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | slight activation, erythroid-specific isoform | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
erythroid-specific isoform ALAS-E, DNA-sequencing and sequence analysis, amino acid sequence determination of precursor protein | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
succinyl-CoA | non-specific isoform ALAS-N in absence of ATP | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
succinyl-CoA | erythroid-specific isoform | Rattus norvegicus | |
6.5 | - |
glycine | erythroid-specific isoform | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
amino acid sequence determination of the purified protein | Rattus norvegicus |
49000 | - |
x * 49000, erythroid-specific isoform, SDS-PAGE | Rattus norvegicus |
64840 | - |
erythroid-specific isoform precursor, DNA-sequence determination | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
non-specific, housekeeping isoform ALAS-N and erythroid-specific isoform ALAS-E | - |
Purification (Comment) | Organism |
---|---|
erythroid-specific isoform from reticulocytes, papain digestion method | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
reticulocyte | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.87 | - |
purified erythroid-specific isoform | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | - |
Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 49000, erythroid-specific isoform, SDS-PAGE | Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
erythroid-specific isoform | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |