Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 2.3.1.37 - 5-aminolevulinate synthase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bishop, D.F.; Henderson, A.S.; Astrin, K.H.
Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome
Genomics
7
207-214
1990
Homo sapiens
Manually annotated by BRENDA team
Ramaswamy, N.K.; Madhusudanan Nair, P.
delta-Aminolevulinic acid synthetase from cold-stored potatoes
Biochim. Biophys. Acta
293
269-277
1973
Solanum tuberosum
Manually annotated by BRENDA team
Tait, G.H.
Aminolaevulinate synthetase of Micrococcus denitrificans. Purification and properties of the enzyme, and the effect of growth conditions on the enzyme activity in cells
Biochem. J.
131
389-403
1973
Paracoccus denitrificans
Manually annotated by BRENDA team
Warnick, G.R.; Burnham, B.F.
Regulation of prophyrin biosynthesis. Purification and characterization of delta-aminolevulinic acid synthase
J. Biol. Chem.
246
6880-6885
1971
Cereibacter sphaeroides
Manually annotated by BRENDA team
Scholnick, P.L.; Hammaker, L.E.; Marver, H.S.
Souble delta-aminolevulinic acid synthetase of rat liver. I. Some properties of the partially purified enzyme
J. Biol. Chem.
247
4126-4131
1972
Rattus norvegicus
Manually annotated by BRENDA team
Scholnick, P.L.; Hammaker, L.E.; Marver, H.S.
Soluble delta-aminolevulinic acid synthetase of rat liver. II. Studies related to the mechanism of enzyme action and hemin inhibition
J. Biol. Chem.
247
4132-4137
1972
Rattus norvegicus
Manually annotated by BRENDA team
Ades, I.Z.; Friedland, D.M.
Properties of chicken erythrocyte delta-aminolevulinate synthase
Int. J. Biochem.
20
965-969
1988
Gallus gallus
Manually annotated by BRENDA team
Viale, A.A.; Wider, E.A.; Battle, A.M.Del C.
Extraction and characterization of delta-aminolevulinate synthetase
Comp. Biochem. Physiol. B
87
607-613
1987
Rhodopseudomonas palustris
-
Manually annotated by BRENDA team
Fernandez, J.; Gonzalez, O.; Martin, M.; Amil, M.R.
Trout (Salmo gairdenri R.) liver 5-aminolevulinate synthetase
Comp. Biochem. Physiol. B
86
245-249
1987
Oncorhynchus mykiss
Manually annotated by BRENDA team
Kreit, J.
Control of 5-aminolevulinic acid synthetase activity in phototrophic facultative bacteria. Purification and some properties of the enzyme from Rhodospirillum rubrum
Biochimie
63
439-444
1981
Rhodospirillum rubrum
Manually annotated by BRENDA team
Borthwick, I.A.; Srivastava, G.; Pirola, B.A.; May, B.K.; Elliott, W.H.
Purification of hepatic mitochondrial 5-aminolevulinate synthase
Methods Enzymol.
123
395-401
1986
Gallus gallus, Rattus norvegicus
Manually annotated by BRENDA team
Jordan, P.M.; Laghai-Newton, A.
Purification of 5-aminolevulinate synthase
Methods Enzymol.
123
435-443
1986
Cereibacter sphaeroides
Manually annotated by BRENDA team
Jordan, P.M.; Shemin, D.
delta-Aminolevulinic acid synthetase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
339-356
1972
Saccharomyces cerevisiae, Cavia porcellus, Gallus gallus, Oryctolagus cuniculus, Homo sapiens, no activity in Chromatium sp., Propionibacterium freudenreichii subsp. shermanii, Rattus norvegicus, Cereibacter sphaeroides, Rhodospirillum rubrum, Spinacia oleracea, Novispirillum itersonii
-
Manually annotated by BRENDA team
Nandi, D.L.
Studies on delta-aminolevulinic acid synthase of Rhodopseudomonas spheroides. Reversibility of the reaction, kinetic, spectral, and other studies related to the mechanism of action
J. Biol. Chem.
253
8872-8877
1978
Cereibacter sphaeroides
Manually annotated by BRENDA team
Simpson, D.M.; Beattie, D.S.
Purification of a specific activator of solubilized delta-aminolevulinic acid synthetase from rat liver mitochondria
J. Biol. Chem.
255
1630-1634
1980
Rattus norvegicus
Manually annotated by BRENDA team
Scotto, A.W.; Chang, L.F.L.; Beattie, D.S.
The characterization and submitochondrial localization of delta-aminolevulinic acid synthase and an associated amidase in rat liver mitochondria using an improved assay for both enzymes
J. Biol. Chem.
258
81-90
1983
Rattus norvegicus
Manually annotated by BRENDA team
Ferreira, G.C.; Dailey, H.A.
Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization
J. Biol. Chem.
268
584-590
1993
Mus musculus
Manually annotated by BRENDA team
Davies, R.C.; Neuberger, A.
Control of 5-aminolaevulinate synthetase activity in Rhodopseudomonas spheroides. Purification and properties of the high-activity form of the enzyme
Biochem. J.
177
649-659
1979
Cereibacter sphaeroides
Manually annotated by BRENDA team
Davies, R.C.; Neuberger, A.
Control of 5-aminolaevulinate synthetase activity in Rhodopseudomonas spheroides. Binding of pyridoxal phosphate to 5-aminolaevulinate synthetase
Biochem. J.
177
661-671
1979
Cereibacter sphaeroides
Manually annotated by BRENDA team
Ibrahim, N.G.; Gruenspecht, N.R.; Freedman, M.L.
Hemin feedback inhibition at reticulocyte delta-aminolevulinic acid synthetase and delta-aminolevulinic acid dehydratase
Biochem. Biophys. Res. Commun.
80
722-728
1978
Oryctolagus cuniculus
Manually annotated by BRENDA team
Porra, R.J.; Irving, E.A.
The nature of the inhibition of delta-aminolevulinic acid synthetase by hemin
Arch. Biochem. Biophys.
148
37-43
1972
Cereibacter sphaeroides
Manually annotated by BRENDA team
Tuboi, S.; Hayasaka, S.
Control of delta-aminolevulinate synthetase activity in Rhodopseudomonas spheroides. I. Partial purification of the inactive form of fraction I
Arch. Biochem. Biophys.
146
282-290
1971
Cereibacter sphaeroides
Manually annotated by BRENDA team
Hayasaka, S.; Tuboi, S.
Control of delta-aminolevulinate synthetase activity in Rhodopseudomonas spheroides. III. Partial purification of the fraction I activating enzyme and the occurrence of two forms of fraction II
J. Biochem.
76
157-168
1974
Cereibacter sphaeroides
Manually annotated by BRENDA team
Clement-Metral, J.D.; Fanica-Gaignier, M.
5-Aminolevulinic-acid synthetases from Rhodopseudomonas spheroides Y. Comparison of the purification and properties of enzymes extracted from bacteria grown in different iron concentrations
Eur. J. Biochem.
59
73-77
1975
Cereibacter sphaeroides, Cereibacter sphaeroides Y
Manually annotated by BRENDA team
Whiting, M.J.; Granick, S.
delta-Aminolevulinic acid synthase from chick embryo liver mitochondria. I. Purification and some properties
J. Biol. Chem.
251
1340-1346
1976
Gallus gallus
Manually annotated by BRENDA team
Paterniti, J.R.; Beattie, D.S.
delta-Aminolevulinic acid synthetase from rat liver mitochondria. Purification and properties
J. Biol. Chem.
254
6112-6118
1979
Rattus norvegicus
Manually annotated by BRENDA team
Nakakuki, M.; Yamauchi, K.; Hayashi, N.; Kikuchi, G.
Purification and some properties of delta-aminolevulinate synthase from the rat liver cytosol fraction and immunochemical identity of the cytosolic enzyme and the mitochondrial enzyme
J. Biol. Chem.
255
1738-1745
1980
Rattus norvegicus
Manually annotated by BRENDA team
Volland, C.; Felix, F.
Isolation and properties of 5-aminolevulinate synthase from the yeast Saccharomyces cerevisiae
Eur. J. Biochem.
142
551-557
1984
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Borthwick, I.A.; Srivastava, G.; Brooker, J.D.; May, B.K.; Elliott, W.H.
Purification of 5-aminolaevulinate synthase from liver mitochondria of chick embryo
Eur. J. Biochem.
129
615-620
1983
Gallus gallus
Manually annotated by BRENDA team
Ohashi, A.; Kikuchi, G.
Purification and some properties of two forms of delta-aminolevulinate synthase from rat liver cytosol
J. Biochem.
85
239-247
1979
Rattus norvegicus
Manually annotated by BRENDA team
Srivastava, G.; Borthwick, I.A.; Brooker, J.D.; May, B.K.; Elliott, W.H.
Purification of rat liver mitochondrial delta-aminolaevulinate synthase
Biochem. Biophys. Res. Commun.
109
305-312
1982
Rattus norvegicus
Manually annotated by BRENDA team
Sato, K.; Ishida, K.; Mutsushika, O.; Shimizu, S.
Purification and some properties of delta-aminolevulinate acid synthases from Protaminobacter ruber and Rhodopseudomonas speroides
Agric. Biol. Chem.
49
3415-3421
1985
Serratia plymuthica, Cereibacter sphaeroides
-
Manually annotated by BRENDA team
Sato, K.; Ishida, K.; Shirai, M.; Shimizu, S.
Occurence and some properties of two types of delta-amino levulinic acid synthase in a facultative methylotoph, Protaminobacter ruber
Agric. Biol. Chem.
49
3423-3428
1985
Serratia plymuthica
-
Manually annotated by BRENDA team
Murthy, V.V.; Woods, J.S.
Solubilization and partial purification of mitochondrial delta-aminolevulinate synthase from fetal rat liver
Biochim. Biophys. Acta
350
240-246
1974
Rattus norvegicus
Manually annotated by BRENDA team
Yubisui, T.; Yoneyama, Y.
delta-Aminolevulinic acid synthetase of Rhodopseudomonas spheroides: purification and properties of the enzyme
Arch. Biochem. Biophys.
150
77-85
1972
Cereibacter sphaeroides
Manually annotated by BRENDA team
Whiting, M.J.; Elliott, W.H.
Purification and properties of solubilized mitochondrial delta-aminolevulinic acid synthetase and comparison with the cytosol enzyme
J. Biol. Chem.
247
6818-6826
1972
Cavia porcellus, Rattus norvegicus
Manually annotated by BRENDA team
Fanica-Gaignier, M.; Clement-Metral, J.
5-Aminolevulinic-acid synthetase of Rhodopseudomonas spheroides Y. Purification and some properties
Eur. J. Biochem.
40
13-18
1973
Cereibacter sphaeroides, Cereibacter sphaeroides Y
Manually annotated by BRENDA team
Fanica-Gaignier, M.; Clement-Metral, J.
5-Aminolevulinic-acid synthetase of Rhodopseudomonas spheroides Y. Kinetic mechanism and inhibition by ATP
Eur. J. Biochem.
40
19-24
1973
Cereibacter sphaeroides, Cereibacter sphaeroides Y
Manually annotated by BRENDA team
Hofer, T.; Wenger, R.H.; Kramer, M.F.; Ferreira, G.C.; Gassmann, M.
Hypoxic up-regulation of erythroid 5-aminolevulinate synthase
Blood
101
348-350
2003
Mus musculus
Manually annotated by BRENDA team
Lake-Bullock, H.; Dailey, H.A.
Biphasic ordered induction of heme synthesis in differentiating murine erythroleukemia cells: role of erythroid 5-aminolevulinate synthase
Mol. Cell. Biol.
13
7122-7132
1993
Mus musculus
Manually annotated by BRENDA team
Munakata, H.; Yamagami, T.; Nagai, T.; Yamamoto, M.; Hayashi, N.
Purification and structure of rat erythroid-specific delta-aminolevulinate synthase
J. Biochem.
114
103-111
1993
Rattus norvegicus
Manually annotated by BRENDA team
Ferreira, G.C.; Vajapey, U.; Hafez, O.; Hunter, G.A.; Barber, M.J.
Aminolevulinate synthase: lysine 313 is not essential for binding the pyridoxal phosphate cofactor but is essential for catalysis
Protein Sci.
4
1001-1006
1995
Mus musculus
Manually annotated by BRENDA team
Ferreira, G.C.; Gong, J.
5-Aminolevulinate synthase and the first step of heme biosynthesis
J. Bioenerg. Biomembr.
27
151-159
1995
Agrobacterium tumefaciens, Aspergillus nidulans, Bradyrhizobium japonicum, Saccharomyces cerevisiae, Gallus gallus, Euglena gracilis, Homo sapiens, Paracoccus denitrificans, Mus musculus, Rattus norvegicus, Sinorhizobium meliloti, Rhodobacter capsulatus, Cereibacter sphaeroides
Manually annotated by BRENDA team
Gong, J.; Kay, C.J.; Barber, M.J.; Ferreira, G.C.
Mutations at a glycine loop in aminolevulinate synthase affect pyridoxal phosphate cofactor binding and catalysis
Biochemistry
35
14109-14117
1996
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Tan, D.; Ferreira, G.C.
Active site of 5-aminolevulinate synthase resides at the subunit interface. Evidence from in vivo heterodimer formation
Biochemistry
35
8934-8941
1996
Saccharomyces cerevisiae, Mus musculus
Manually annotated by BRENDA team
Dailey, H.A.; Dailey, T.A.
Expression and purification of mammalian 5-aminolevulinate synthase
Methods Enzymol.
281
336-340
1997
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Zavgorodnyaya, A.; Papenbrock, J.; Grimm, B.
Yeast 5-aminolevulinate synthase provides additional chlorophyll precursor in transgenic tobacco
Plant J.
12
169-178
1997
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Tan, D.; Barber, M.J.; Ferreira, G.C.
The role of tyrosine 121 in cofactor binding of 5-aminolevulinate synthase
Protein Sci.
7
1208-1213
1998
Mus musculus
Manually annotated by BRENDA team
Gong, J.; Hunter, G.A.; Ferreira, G.C.
Aspartate-279 in aminolevulinate synthase affects enzyme catalysis through enhancing the function of the pyridoxal 5'-phosphate cofactor
Biochemistry
37
3509-3517
1998
Mus musculus
Manually annotated by BRENDA team
Tan, D.; Harrison, T.; Hunter, G.A.; Ferreira, G.C.
Role of arginine 439 in substrate binding of 5-aminolevulinate synthase
Biochemistry
37
1478-1484
1998
Mus musculus
Manually annotated by BRENDA team
Kaliman, P.A.; Barannik, T.V.
Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress
Biochemistry
64
699-704
1999
Rattus norvegicus
Manually annotated by BRENDA team
Hunter, G.A.; Ferreira, G.C.
Lysine-313 of 5-aminolevulinate synthase acts as a general base during formation of the quinonoid reaction intermediates
Biochemistry
38
3711-3718
1999
Mus musculus
Manually annotated by BRENDA team
Varadharajan, S.; Dhanasekaran, S.; Bonday, Z.Q.; Rangarajan, P.N.; Padmanaban, G.
Involvement of delta-aminolevulinate synthase encoded by the parasite gene in de novo heme synthesis by Plasmodium falciparum
Biochem. J.
367
321-327
2002
Plasmodium falciparum
Manually annotated by BRENDA team
Zhang, J.; Ferreira, G.C.
Transient state kinetic investigation of 5-aminolevulinate synthase reaction mechanism
J. Biol. Chem.
277
44660-44669
2002
Mus musculus
Manually annotated by BRENDA team
Xie, L.; Hall, D.; Eiteman, M.A.; Altman, E.
Optimization of recombinant aminolevulinate synthase production in Escherichia coli using factorial design
Appl. Microbiol. Biotechnol.
63
267-273
2003
Cereibacter sphaeroides
Manually annotated by BRENDA team
Dailey, T.A.; Woodruff, J.H.; Dailey, H.A.
Examination of mitochondrial protein targeting of haem synthetic enzymes: in vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthase
Biochem. J.
386
381-386
2005
Homo sapiens (P13196)
Manually annotated by BRENDA team
Shoolingin-Jordan, P.M.; Al-Daihan, S.; Alexeev, D.; Baxter, R.L.; Bottomley, S.S.; Kahari, I.D.; Roy, I.; Sarwar, M.; Sawyer, L.; Wang, S.F.
5-Aminolevulinic acid synthase: mechanism, mutations and medicine
Biochim. Biophys. Acta
1647
361-366
2003
Homo sapiens, Cereibacter sphaeroides
Manually annotated by BRENDA team
Choi, H.P.; Hong, J.W.; Rhee, K.H.; Sung, H.C.
Cloning, expression, and characterization of 5-aminolevulinic acid synthase from Rhodopseudomonas palustris KUGB306
FEMS Microbiol. Lett.
236
175-181
2004
Rhodopseudomonas palustris (Q6RVB3), Rhodopseudomonas palustris KUGB306 (Q6RVB3), Rhodopseudomonas palustris KUGB306
Manually annotated by BRENDA team
Cox, T.C.; Sadlon, T.J.; Schwarz, Q.P.; Matthews, C.S.; Wise, P.D.; Cox, L.L.; Bottomley, S.S.; May, B.K.
The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis
Int. J. Biochem. Cell Biol.
36
281-295
2004
Homo sapiens
Manually annotated by BRENDA team
Cheltsov, A.V.; Guida, W.C.; Ferreira, G.C.
Circular permutation of 5-aminolevulinate synthase: effect on folding, conformational stability, and structure
J. Biol. Chem.
278
27945-27955
2003
Mus musculus
Manually annotated by BRENDA team
Zhang, J.; Cheltsov, A.V.; Ferreira, G.C.
Conversion of 5-aminolevulinate synthase into a more active enzyme by linking the two subunits: spectroscopic and kinetic properties
Protein Sci.
14
1190-1200
2005
Mus musculus
Manually annotated by BRENDA team
Guberman, A.S.; Scassa, M.E.; Canepa, E.T.
Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways
Arch. Biochem. Biophys.
436
285-296
2005
Homo sapiens
Manually annotated by BRENDA team
Abu-Farha, M.; Niles, J.; Willmore, W.G.
Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition
Biochem. Cell Biol.
83
620-630
2005
Homo sapiens
Manually annotated by BRENDA team
Rodriguez, J.A.; Martinez, M.D.; Gerez, E.; Batlle, A.; Buzaleh, A.M.
Heme oxygenase, aminolevulinate synthetase and the antioxidant system in the brain of mice treated with porphyrinogenic drugs
Cell. Mol. Biol.
51
487-494
2005
Mus musculus
Manually annotated by BRENDA team
Astner, I.; Schulze, J.O.; van den Heuvel, J.; Jahn, D.; Schubert, W.D.; Heinz, D.W.
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans
EMBO J.
24
3166-3177
2005
Rhodobacter capsulatus (P18079), Rhodobacter capsulatus
Manually annotated by BRENDA team
Wang, J.; Wu, J.; Zhang, Z.
Expression of 5-aminolevulinic acid synthase in recombinant Escherichia coli
World J. Microbiol. Biotechnol.
22
461-468
2006
Escherichia coli
Manually annotated by BRENDA team
Tahara, T.; Tanaka, M.; Nozaki, S.; Jin, G.; Onoe, H.; Watanabe, Y.
Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue
Biochem. Biophys. Res. Commun.
353
1068-1073
2007
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Han, L.; Zhong, Y.; Huang, B.; Han, L.; Pan, L.; Xu, X.; Wang, X.; Huang, B.; Lu, J.
Sodium butyrate activates erythroid-specific 5-aminolevulinate synthase gene through Sp1 elements at its promoter
Blood Cells Mol. Dis.
41
148-153
2008
Homo sapiens (P22557)
Manually annotated by BRENDA team
Hunter, G.A.; Zhang, J.; Ferreira, G.C.
Transient kinetic studies support refinements to the chemical and kinetic mechanisms of aminolevulinate synthase
J. Biol. Chem.
282
23025-23035
2007
Mus musculus
Manually annotated by BRENDA team
Martini, C.N.; Romero, D.G.; Yanes, L.L.; Vila, M.d.e.l..C.
Induction of 5-aminolevulinate synthase by activators of steroid biosynthesis
Life Sci.
81
19-25
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Lin, J.; Fu, W.; Cen, P.
Characterization of 5-aminolevulinate synthase from Agrobacterium radiobacter, screening new inhibitors for 5-aminolevulinate dehydratase from Escherichia coli and their potential use for high 5-aminolevulinate production
Biores. Technol.
100
2293-2297
2009
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Liu, X.; Wang, L.; Wang, Y.; Cai, L.
d-Glucose enhanced 5-aminolevulinic acid production in recombinant Escherichia coli culture
Appl. Biochem. Biotechnol.
160
822-830
2009
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Huang, Q.; Li, J.; Feng, W.; Xu, Y.; Huang, Z.; Lv, S.; Zhou, H.; Gao, L.
Erythroid 5-aminolevulinate synthase mediates the upregulation of membrane band 3 protein expression by iron
Cell Biochem. Funct.
28
122-125
2010
Homo sapiens (P22557)
Manually annotated by BRENDA team
du Plessis, N.; Kimberg, M.; Zaahl, M.G.; Sadie, A.; Venter, M.; van der Merwe, L.; Louw, A.; Warnich, L.
Functional analysis of the 5 regulatory region of the 5-aminolevulinate synthase (ALAS1) gene in response to estrogen
Cell. Mol. Biol.
55
20-30
2009
Homo sapiens
Manually annotated by BRENDA team
Buzaleh, A.M.; Moran-Jimenez, M.J.; Garcia-Bravo, M.; Sampedro, A.; Batlle, A.M.; Enriquez de Salamanca, R.; Fontanellas, A.
Induction of hepatic aminolevulinate acid synthetase activity by isoflurane in a genetic model for erythropoietic protoporphyria
Cell. Mol. Biol.
55
38-44
2009
Mus musculus
Manually annotated by BRENDA team
Kaneko, K.; Furuyama, K.; Aburatani, H.; Shibahara, S.
Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling
FEBS J.
276
1370-1382
2009
Homo sapiens
Manually annotated by BRENDA team
Okano, S.; Zhou, L.; Kusaka, T.; Shibata, K.; Shimizu, K.; Gao, X.; Kikuchi, Y.; Togashi, Y.; Hosoya, T.; Takahashi, S.; Nakajima, O.; Yamamoto, M.
Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse
Genes Cells
15
77-89
2010
Mus musculus
Manually annotated by BRENDA team
Lendrihas, T.; Hunter, G.A.; Ferreira, G.C.
Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase
J. Biol. Chem.
285
3351-3359
2010
Mus musculus
Manually annotated by BRENDA team
Choi, H.P.; Lee, Y.M.; Yun, C.W.; Sung, H.C.
Extracellular 5-aminolevulinic acid production by Escherichia coli containing the Rhodopseudomonas palustris KUGB306 hemA gene
J. Microbiol. Biotechnol.
18
1136-1140
2008
Rhodopseudomonas palustris
Manually annotated by BRENDA team
Dwyer, B.E.; Smith, M.A.; Richardson, S.L.; Perry, G.; Zhu, X.
Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimers disease
Neurosci. Lett.
460
180-184
2009
Homo sapiens
Manually annotated by BRENDA team
Jung, S.; Back, K.; Yang, K.; Kuk, Y.; Chon, S.
Defence response produced during photodynamic damage in transgenic rice overexpressing 5-aminolevulinic acid synthase
Photosynthetica
46
3-9
2008
Bradyrhizobium japonicum
-
Manually annotated by BRENDA team
Lendrihas, T.; Zhang, J.; Hunter, G.A.; Ferreira, G.C.
Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity
Protein Sci.
18
1847-1859
2009
Mus musculus
Manually annotated by BRENDA team
Turbeville, T.D.; Zhang, J.; Adams, W.C.; Hunter, G.A.; Ferreira, G.C.
Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase
Arch. Biochem. Biophys.
511
107-117
2011
Mus musculus
Manually annotated by BRENDA team
Zhang, F.L.; Shen, G.M.; Liu, X.L.; Wang, F.; Zhao, H.L.; Yu, J.; Zhang, J.W.
Hypoxic induction of human erythroid-specific sigma-aminolevulinate synthase mediated by hypoxia-inducible factor 1
Biochemistry
50
1194-1202
2011
Homo sapiens
Manually annotated by BRENDA team
Shaik, K.S.; Meyer, F.; Vazquez, A.V.; Floetenmeyer, M.; Cerdan, M.E.; Moussian, B.
Sigma-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva
Eur. J. Cell Biol.
91
204-215
2012
Drosophila melanogaster
Manually annotated by BRENDA team
Kadirvel, S.; Furuyama, K.; Harigae, H.; Kaneko, K.; Tamai, Y.; Ishida, Y.; Shibahara, S.
The carboxyl-terminal region of erythroid-specific 5-aminolevulinate synthase acts as an intrinsic modifier for its catalytic activity and protein stability
Exp. Hematol.
40
477-486.e1
2012
Homo sapiens
Manually annotated by BRENDA team
Lendrihas, T.; Hunter, G.A.; Ferreira, G.C.
Targeting the active site gate to yield hyperactive variants of 5-aminolevulinate synthase
J. Biol. Chem.
285
13704-13711
2010
Escherichia coli
Manually annotated by BRENDA team
Kiatpapan, P.; Phonghatsabun, M.; Yamashita, M.; Murooka, Y.; Panbangred, W.
Production of 5-aminolevulinic acid by Propionibacterium acidipropionici TISTR442
J. Biosci. Bioeng.
111
425-428
2011
Acidipropionibacterium acidipropionici
Manually annotated by BRENDA team
Ogawa-Otomo, A.; Kurisaki, A.; Ito, Y.
Aminolevulinate synthase 2 mediates erythrocyte differentiation by regulating larval globin expression during Xenopus primary hematopoiesis
Biochem. Biophys. Res. Commun.
456
476-481
2015
Xenopus laevis (Q68F30), Xenopus laevis
Manually annotated by BRENDA team
Fratz, E.J.; Clayton, J.; Hunter, G.A.; Ducamp, S.; Breydo, L.; Uversky, V.N.; Deybach, J.C.; Gouya, L.; Puy, H.; Ferreira, G.C.
Human erythroid 5-aminolevulinate synthase mutations associated with X-linked protoporphyria disrupt the conformational equilibrium and enhance product release
Biochemistry
54
5617-5631
2015
Homo sapiens (P22557), Homo sapiens
Manually annotated by BRENDA team
Stojanovski, B.M.; Breydo, L.; Hunter, G.A.; Uversky, V.N.; Ferreira, G.C.
Catalytically active alkaline molten globular enzyme: effect of pH and temperature on the structural integrity of 5-aminolevulinate synthase
Biochim. Biophys. Acta
1844
2145-2154
2014
Mus musculus (P08680)
Manually annotated by BRENDA team
Stojanovski, B.M.; Ferreira, G.C.
Murine erythroid 5-aminolevulinate synthase: adenosyl-binding site Lys221 modulates substrate binding and catalysis
FEBS open bio
5
824-831
2015
Mus musculus (P08680), Mus musculus
Manually annotated by BRENDA team
Stojanovski, B.M.; Hunter, G.A.; Jahn, M.; Jahn, D.; Ferreira, G.C.
Unstable reaction intermediates and hysteresis during the catalytic cycle of 5-aminolevulinate synthase: implications from using pseudo and alternate substrates and a promiscuous enzyme variant
J. Biol. Chem.
289
22915-22925
2014
Mus musculus (P08680), Mus musculus
Manually annotated by BRENDA team
Stojanovski, B.M.; Ferreira, G.C.
Asn-150 of murine erythroid 5-aminolevulinate synthase modulates the catalytic balance between the rates of the reversible reaction
J. Biol. Chem.
290
30750-30761
2015
Mus musculus (P08680), Mus musculus
Manually annotated by BRENDA team
Bishop, D.F.; Tchaikovskii, V.; Nazarenko, I.; Desnick, R.J.
Molecular expression and characterization of erythroid-specific 5-aminolevulinate synthase gain-of-function mutations causing X-linked protoporphyria
Mol. Med.
19
18-25
2013
Homo sapiens (P22557)
Manually annotated by BRENDA team
Fratz, E.J.; Hunter, G.A.; Ferreira, G.C.
Expression of murine 5-aminolevulinate synthase variants causes protoporphyrin IX accumulation and light-induced mammalian cell death
PLoS ONE
9
e93078
2014
Mus musculus (P08680), Mus musculus
Manually annotated by BRENDA team
Stojanovski, B.M.; Breydo, L.; Uversky, V.N.; Ferreira, G.C.
The unfolding pathways of the native and molten globule states of 5-aminolevulinate synthase
Biochem. Biophys. Res. Commun.
480
321-327
2016
Mus musculus (P08680)
Manually annotated by BRENDA team
Fratz-Berilla, E.J.; Breydo, L.; Gouya, L.; Puy, H.; Uversky, V.N.; Ferreira, G.C.
Isoniazid inhibits human erythroid 5-aminolevulinate synthase Molecular mechanism and tolerance study with four X-linked protoporphyria patients
Biochim. Biophys. Acta
1863
428-439
2017
Homo sapiens (P22557), Homo sapiens
Manually annotated by BRENDA team
Stojanovski, B.M.; Breydo, L.; Uversky, V.N.; Ferreira, G.C.
Murine erythroid 5-aminolevulinate synthase Truncation of a disordered N-terminal extension is not detrimental for catalysis
Biochim. Biophys. Acta
1864
441-452
2016
Mus musculus (P08680), Mus musculus
Manually annotated by BRENDA team
Tan, Z.; Zhao, J.; Chen, J.; Rao, D.; Zhou, W.; Chen, N.; Zheng, P.; Sun, J.; Ma, Y.
Enhancing thermostability and removing hemin inhibition of Rhodopseudomonas palustris 5-aminolevulinic acid synthase by computer-aided rational design
Biotechnol. Lett.
41
181-191
2019
Rhodopseudomonas palustris
Manually annotated by BRENDA team
Honda, Y.; Nanasawa, K.; Fujii, H.
Coexpression of 5-aminolevulinic acid synthase gene facilitates heterologous production of thermostable cytochrome P450, CYP119, in holo form in Escherichia coli
ChemBioChem
19
2156-2159
2018
Rhodobacter capsulatus
Manually annotated by BRENDA team
Pedrosa-Gerasmio, I.R.; Kondo, H.; Hirono, I.
Molecular cloning, characterization and gene expression analysis of aminolevulinic acid synthase in Litopenaeus vannamei
Gene
736
144421
2020
Penaeus vannamei
Manually annotated by BRENDA team
Na, I.; Catena, D.; Kong, M.J.; Ferreira, G.C.; Uversky, V.N.
Anti-correlation between the dynamics of the active site loop and C-terminal tail in relation to the homodimer asymmetry of the mouse erythroid 5-aminolevulinate synthase
Int. J. Mol. Sci.
19
1899
2018
Mus musculus (P08680), Mus musculus
Manually annotated by BRENDA team
Na, I.; DeForte, S.; Stojanovski, B.M.; Ferreira, G.C.; Uversky, V.N.
Molecular dynamics analysis of the structural and dynamic properties of the functionally enhanced hepta-variant of mouse 5-aminolevulinate synthase
J. Biomol. Struct. Dyn.
36
152-165
2018
Mus musculus (P08680), Mus musculus, Rhodobacter capsulatus (P18079), Rhodobacter capsulatus, Rhodobacter capsulatus ATCC BAA-309 (P18079)
Manually annotated by BRENDA team
Badawy, A.A.
Hypothesis Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias
Med. Hypotheses
131
109314
2019
Rattus norvegicus
Manually annotated by BRENDA team
Stojanovski, B.M.; Hunter, G.A.; Na, I.; Uversky, V.N.; Jiang, R.H.Y.; Ferreira, G.C.
5-Aminolevulinate synthase catalysis The catcher in heme biosynthesis
Mol. Genet. Metab.
128
178-189
2019
Mus musculus (P08680), Mus musculus
Manually annotated by BRENDA team
Barman-Aksoezen, J.; Halloy, F.; Iyer, P.S.; Schuemperli, D.; Minder, A.E.; Hall, J.; Minder, E.I.; Schneider-Yin, X.
Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria
Mol. Genet. Metab.
128
304-308
2019
Homo sapiens (P22557), Homo sapiens
Manually annotated by BRENDA team
Stoian, N.; Kaganjo, J.; Zeilstra-Ryalls, J.
Resolving the roles of the Rhodobacter sphaeroides HemA and HemT 5-aminolevulinic acid synthases
Mol. Microbiol.
110
1011-1029
2018
Cereibacter sphaeroides, Cereibacter sphaeroides (Q04512), Cereibacter sphaeroides ATCC17023 (Q04512), Cereibacter sphaeroides ATCC17029, Cereibacter sphaeroides ATCC17025
Manually annotated by BRENDA team
Yien, Y.Y.; Ducamp, S.; van der Vorm, L.N.; Kardon, J.R.; Manceau, H.; Kannengiesser, C.; Bergonia, H.A.; Kafina, M.D.; Karim, Z.; Gouya, L.; Baker, T.A.; Puy, H.; Phillips, J.D.; Nicolas, G.; Paw, B.H.
Mutation in human CLPX elevates levels of delta-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria
Proc. Natl. Acad. Sci. USA
114
E8045-E8052
2017
Homo sapiens
Manually annotated by BRENDA team
Liu, J.; Kaganjo, J.; Zhang, W.; Zeilstra-Ryalls, J.
Investigating the bifunctionality of cyclizing and classical 5-aminolevulinate synthases
Protein Sci.
27
402-410
2018
Cereibacter sphaeroides
Manually annotated by BRENDA team
Ikushiro, H.; Nagami, A.; Takai, T.; Sawai, T.; Shimeno, Y.; Hori, H.; Miyahara, I.; Kamiya, N.; Yano, T.
Heme-dependent inactivation of 5-aminolevulinate synthase from Caulobacter crescentus
Sci. Rep.
8
14228
2018
Caulobacter vibrioides (Q9A8J8), Caulobacter vibrioides, Caulobacter vibrioides CB15 (Q9A8J8)
Manually annotated by BRENDA team
Brown, B.L.; Kardon, J.R.; Sauer, R.T.; Baker, T.A.
Structure of the mitochondrial aminolevulinic acid synthase, a key heme biosynthetic enzyme
Structure
26
580-589.e4
2018
Saccharomyces cerevisiae (P09950), Saccharomyces cerevisiae
Manually annotated by BRENDA team