2.3.1.37: 5-aminolevulinate synthase
This is an abbreviated version!
For detailed information about 5-aminolevulinate synthase, go to the full flat file.
Word Map on EC 2.3.1.37
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2.3.1.37
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heme
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porphyria
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sideroblastic
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oxygenase
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anemia
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x-linked
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ferrochelatase
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hemoglobin
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marrow
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porphobilinogen
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dehydratase
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pyridoxal
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uroporphyrinogen
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protoporphyria
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iron-responsive
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hemoprotein
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erythroblast
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phenobarbital
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erythropoietic
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tetrapyrrole
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rhodopseudomonas
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rhodobacter
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microcytic
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porphyrinogenic
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erythroleukemia
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delta-aminolaevulinate
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allylisopropylacetamide
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uroporphyrin
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medicine
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synthesis
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hypochromic
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pharmacology
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gata1
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aip
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hexachlorobenzene
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plp-dependent
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cutanea
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5'-phosphate-dependent
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phenobarbital-induced
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biotechnology
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neurovisceral
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nutrition
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rate-controlling
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pyrrolase
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protoporphyrinogen
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heme-mediated
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tarda
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5-aminolaevulinate
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succinyl-coenzyme
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bacteriochlorophyll
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coproporphyrinogen
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agriculture
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harderian
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succinylacetone
- 2.3.1.37
- heme
- porphyria
-
sideroblastic
- oxygenase
- anemia
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x-linked
-
ferrochelatase
- hemoglobin
- marrow
- porphobilinogen
- dehydratase
- pyridoxal
- uroporphyrinogen
- protoporphyria
-
iron-responsive
- hemoprotein
- erythroblast
- phenobarbital
-
erythropoietic
- tetrapyrrole
- rhodopseudomonas
- rhodobacter
-
microcytic
-
porphyrinogenic
- erythroleukemia
-
delta-aminolaevulinate
-
allylisopropylacetamide
-
uroporphyrin
- medicine
- synthesis
-
hypochromic
- pharmacology
- gata1
- aip
- hexachlorobenzene
-
plp-dependent
-
cutanea
-
5'-phosphate-dependent
-
phenobarbital-induced
- biotechnology
-
neurovisceral
- nutrition
-
rate-controlling
-
pyrrolase
- protoporphyrinogen
-
heme-mediated
- tarda
-
5-aminolaevulinate
-
succinyl-coenzyme
- bacteriochlorophyll
- coproporphyrinogen
- agriculture
-
harderian
- succinylacetone
Reaction
Synonyms
5-ALA synthase, 5-ALAS, 5-aminolevulinate synthase, 5-aminolevulinate synthetase, 5-aminolevulinic acid synthase, 5-aminolevulinic acid synthetase, ALA, ALA synthase, ALA synthetase, ALA-S, ALAS, ALAS2, alpha-aminolevulinic acid synthase, aminolevulinate synthase, aminolevulinate synthase 2, aminolevulinate synthetase, aminolevulinic acid synthase, aminolevulinic acid synthase 2, aminolevulinic acid synthetase, aminolevulinic synthetase, delta-ALAS, delta-aminolevulinate synthase, delta-aminolevulinate synthetase, delta-aminolevulinic acid synthase, delta-aminolevulinic acid synthase 2, delta-aminolevulinic acid synthetase, delta-aminolevulinic synthetase, erythroid 5-aminolevulinate synthase, erythroid-specific 5-aminolevulinate synthase, Hem1, hemA, HemT, mALAS-2, sigma-aminolevulinate synthase, synthase, aminolevulinate, synthetase, aminolevulinate
ECTree
2.3.1.37 5-aminolevulinate synthaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.3.1.37 - 5-aminolevulinate synthase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
FeCl3
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addition of imidazole at 0.2 mM prior to FeCl3 prevents inhibition
isoniazid
about 25% residual activity at 0.01 mM. Isoniazid directly inhibits the enzyme, noncompetitively or uncompetitively. about 0.4 mM pyridoxal 5'-phosphate and PMP reduce the effect of isoniazid on isoform ALAS2 inhibition
Borohydride
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aminomalonate protects; in presence of pyridoxal 5'-phosphate
Co2+
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accumulation of Co2+-protoporphyrin containing products of hemolysis
delta-aminolevuinate
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competitive against glycine, noncompetitive against succinyl-CoA
divalent cations
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Mg2+ or Ca2+: optimal at concentration of 50 mM, inhibition above 200 mM
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divalent cations
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at high concentration, relative order of inhibition: Co2+, Mn2+, Mg2+, Ca2+
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hemin
in the presence of 0.001 mM hemin, wild type isoform HemA retains 69% of its activity; in the presence of 0.001 mM hemin, wild type isoform HemT retains 90% of its activity while isoform HemA retains 62% of its activity
hemin
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inhibition of the import of the enzyme into the mitochondrial matrix
hemin
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inhibition of the import of the enzyme into the mitochondrial matrix
hemin
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inhibition of the import of the enzyme into the mitochondrial matrix
metalloporphyrins
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containing Co2+, Zn2+ or Mg2+
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monovalent cations
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in Mg2+-containing medium: Na+ or Li+ at 100 mM have no effect on activity, higher concentrations are totally inhibitory
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additional information
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not inhibitory: D-glucose, D-fructose, D-xylose, D-mannose, L-arabinose, D-galactose, lactose, sucrose and maltose
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additional information
recombinant enzyme is inactivated via a heme-mediated feedback manner, in which the essential coenzyme pyridoxal 5'-phosphate is released to form the inactive heme-bound enzyme
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additional information
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recombinant enzyme is inactivated via a heme-mediated feedback manner, in which the essential coenzyme pyridoxal 5'-phosphate is released to form the inactive heme-bound enzyme
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additional information
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product inhibition pattern for the forward reaction and the reverse reaction
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additional information
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presence of high salt concentration in the sample buffer and running buffer of aggregated enzyme preparation results in inactivation
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additional information
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cysteine, glutathione, cystine or 2-mercaptoethanol diminishes activity in presence of 5-aminolevulinate
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