1.4.3.22: diamine oxidase
This is an abbreviated version!
For detailed information about diamine oxidase, go to the full flat file.
Word Map on EC 1.4.3.22
-
1.4.3.22
-
polyamine
-
oxidases
-
monoamine
-
mucosal
-
copper
-
spermidine
-
deamination
-
1.4.3.6
-
aminoguanidine
-
benzylamine
-
endotoxin
-
ornithine
-
semicarbazide-sensitive
-
occludin
-
d-lactate
-
copper-containing
-
cadaverine
-
bowel
-
biogenic
-
semicarbazide
-
villus
-
ileum
-
d-lactic
-
jejunal
-
lysyl
-
tyramine
-
zonula
-
piglets
-
pao
-
claudin-1
-
methylamine
-
n-methyltransferase
-
pargyline
-
agmatine
-
tryptamine
-
renalase
-
hansenula
-
occludens-1
-
postheparin
-
phenylhydrazine
-
lentil
-
deprenyl
-
beta-aminopropionitrile
-
oxidase-like
-
clorgyline
-
beta-phenylethylamine
-
phenylethylamine
-
quinoproteins
-
samdc
-
globiformis
-
diagnostics
-
analysis
-
biotechnology
-
medicine
- 1.4.3.22
- polyamine
- oxidases
-
monoamine
- mucosal
- copper
- spermidine
-
deamination
-
1.4.3.6
- aminoguanidine
- benzylamine
- endotoxin
- ornithine
-
semicarbazide-sensitive
- occludin
- d-lactate
-
copper-containing
- cadaverine
- bowel
-
biogenic
- semicarbazide
- villus
- ileum
-
d-lactic
- jejunal
-
lysyl
- tyramine
-
zonula
-
piglets
- pao
-
claudin-1
- methylamine
- n-methyltransferase
- pargyline
- agmatine
- tryptamine
- renalase
- hansenula
-
occludens-1
-
postheparin
- phenylhydrazine
- lentil
- deprenyl
- beta-aminopropionitrile
-
oxidase-like
- clorgyline
- beta-phenylethylamine
- phenylethylamine
-
quinoproteins
- samdc
- globiformis
- diagnostics
- analysis
- biotechnology
- medicine
Reaction
Synonyms
ABP1, AGAO, Amiloride-binding protein, Amine oxidase, BSAO, Copper amine oxidase, DAO, DAO-1, Diamine oxidase, EC 1.4.3.6, ELAO, GPAO, hDAO, histaminase, histamine dehydrogenase, histamine oxidase, LCAO, LSAO, methylputrescine oxidase, More, MPO, N-methylputrescine oxidase, pea seedling amine oxidase, PKAO, PPLO, PSAO, pWGH15, rhDAO, vDAO
ECTree
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Substrates Products
Substrates Products on EC 1.4.3.22 - diamine oxidase
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REACTION DIAGRAM
1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
1,5-diamino-3-oxapentane + H2O + O2
?
-
the relative reaction rate with is 13% of that with putrescine
-
-
?
1,8-diamino-3,6-dioxaoctane + H2O + O2
?
-
the relative reaction rate with is 20% of that with putrescine
-
-
?
2-(3,4-dihydroxyphenyl)-ethylamine + H2O + O2
3,4-dihydroxyphenylacetaldehyde + NH3 + H2O2
-
-
?
2-aminoethylpyridine + H2O + O2
pyridin-2-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
2-aminomethylpyridine + H2O + O2
2-pyridincarbaldehyde + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
r
4-aminomethylpyridine dihydrochloride + H2O + O2
?
8% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (putrescine, 1 mM) for various amine oxidases
-
-
?
4-dimethylaminomethylbenzylamine + H2O + O2
4-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
-
r
beta-phenylethylamine + O2 + H2O
beta-phenylethanal + NH3 + H2O2
-
-
-
?
hexylamine + H2O + O2
hexanal + NH3 + H2O2
-
41% of the activity with histamine
-
-
?
N-(2-fluoroethyl)putrescine + H2O + O2
N-(2-fluoroethyl)aminobutanal + NH3 + H2O2
-
same activity as with N-methylputrescine as substrate
-
-
?
N-acetyl-1,4-diaminobutane + H2O + O2
N-acetyl-aminobutanal + acetylamine + H2O2
-
8.6% of activity with putrescine
-
?
N-acetyl-1,5-diaminopentane + H2O + O2
N-acetyl-aminopentanal + acetylamine + H2O2
-
3.8% of activity with putrescine
-
?
N-ethylcadaverine + H2O + O2
5-(ethylamino)pentanal + NH3 + H2O2
-
17% activity compared to activity with N-methylputrescine
-
-
?
N-ethylputrescine + H2O + O2
4-(ethylamino)butanal + NH3 + H2O2
-
same activity as with N-methylputrescine as substrate
-
-
?
N-methylcadaverine + H2O + O2
5-(methylamino)pentanal + NH3 + H2O2
-
16% activity compared to activity with N-methylputrescine
-
-
?
N-n-propylputrescine + H2O + O2
4-propylaminobutanal + NH3 + H2O2
-
50% of the activity compared to N-methylputrescine as substrate
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
pentylamine + H2O + O2
pentanal + NH3 + H2O2
-
32% of the activity with histamine
-
-
?
4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
(E)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
4-aminobut-2-enal + NH3 + H2O2
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
10-aminodecanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
109% of activity with putrescine
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
30% activity compared to activity with N-methylputrescine
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
30% activity compared to activity with putrescine
-
-
?
4-aminobutanal + NH3 + H2O2
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
56% activity compared to activity with N-methylputrescine
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
50% activity compared to activity with N-methylputrescine
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
best substrate
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
5-aminopentanal + NH3 + H2O2
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
most active
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
60% of activity with putrescine
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
-
-
-
?
1-phenylethanal + NH3 + H2O2
-
44% of the activity with histamine
-
-
?
1-phenylethylamine + H2O + O2
1-phenylethanal + NH3 + H2O2
-
44% of the activity with histamine
-
-
?
2-hydroxy-4-aminobutanal + H2O2 + NH3
-
-
-
?
2-hydroxyputrescine + H2O + O2
2-hydroxy-4-aminobutanal + H2O2 + NH3
-
-
-
?
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
?
3-hydroxy-4-aminopentanal + H2O2 + NH3
-
-
-
?
3-hydroxycadaverine + H2O + O2
3-hydroxy-4-aminopentanal + H2O2 + NH3
-
-
-
?
4-phenylbutanal + NH3 + H2O2
-
72.6% of the activity with tyramine
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
53.6% of the activity with tyramine
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
19.3% of the activity with cadaverine
-
-
?
?
-
4% of the activity with histamine
-
-
?
agmatine + H2O + O2
?
-
4% of the activity with histamine
-
-
?
benzaldehyde + NH3 + H2O2
-
88.5% of the activity with tyramine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
29% activity compared to putrescine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
15.3% of the activity with tyramine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
66.5% of the activity with cadaverine
-
-
?
butanal + NH3 + H2O2
-
22% of the activity with histamine
-
-
?
5-aminopentanal + NH3 + H2O2
-
15% activity compared to activity with N-methylputrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
30% activity compared to activity with N-methylputrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
75% activity compared to activity with putrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
80% activity compared to activity with putrescine
-
-
?
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
51% of the activity with histamine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
93.7% of the activity with tyramine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
62.3% of the activity with tyramine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
18.4% of the activity with cadaverine
-
-
?
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
28% of activity with putrescine
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
preferred substrate
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
60% activity compared to activity with putrescine
-
-
?
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
DAO
-
-
?
histamine + O2 + H2O
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
degrades around 75% of the histamine used in a bioconversion experiment with a food-relevant concentration of 150 mg/l
-
-
?
histamine + O2 + H2O
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
degrades around 75% of the histamine used in a bioconversion experiment with a food-relevant concentration of 150 mg/l
-
-
?
N-methyl-3-aminopropanal + NH3 + H2O2
-
40% activity compared to activity with N-methylputrescine
-
-
?
N-methyl-1,3-diaminopropane + H2O + O2
N-methyl-3-aminopropanal + NH3 + H2O2
-
40% activity compared to activity with putrescine
-
-
?
4-(methylamino)butanal + NH3 + H2O2
-
best substrate
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
best substrate. Specificity for N-methylated diamines enable the Hyoscyamine enzyme to function specifically in tropane alkaloid biosynthesis
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
-
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
50% activity compared to activity with putrescine
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
75% activity compared to activity with putrescine
-
-
?
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
propanal + NH3 + H2O2
-
7% of the activity with histamine
-
-
?
putrescine + H2O + O2
?
-
catalytic activity of xenon-treated LSAO towards putrescine is about 40% of that of the native LSAO
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with spermidine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with benzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with p-dimethylaminomethylbenzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
only aliphatic diamines from C4 to C10 and cystamine are oxidized, enzymatic activity decreases sharply with increasing chain length of diamines
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
short-chain aliphatic diamines are deaminated with highest reaction velocity
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with benzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
treatment of diamine oxidase with reducing agents induces ability to catalyze oxidative deamination of substrates of monoamine oxidase EC 1.4.3.4
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
15% of the activity with histamine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
35.2% of the activity with tyramine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
48.4% of the activity with tyramine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
15.7% of the activity with cadaverine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
4-hydroxyphenylethanal + NH3 + H2O2
-
36% of the activity with histamine
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
36% of the activity with histamine
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
19.1% of the activity with cadaverine
-
-
?
?
-
-
no activity with putrescine, cadaverine, spermine, and spermidine
-
-
?
additional information
?
-
-
no activity with putrescine, cadaverine, spermine, and spermidine
-
-
?
additional information
?
-
-
relevance of the enzyme as a H2O2-delivering system in wound response, as well as in the protection against fungal invasion
-
-
?
additional information
?
-
-
polyamine degradation via DAO produces DELTA1-pyrroline, DELTA1-pyrroline can be catabolized to gamma-aminobutyric acid, which is converted via transamination and oxidation to succinate and successively introduced in the Krebs cycle.
-
-
?
additional information
?
-
hDAO is unique among CAOs in that it has a distinct substrate preference for diamines
-
-
?
additional information
?
-
-
hDAO is unique among CAOs in that it has a distinct substrate preference for diamines
-
-
?
additional information
?
-
active site of hDAO: contacts made by cofactor trihydroxyphenylalanine quinone to the active-site Cu2+, and Thr685 and to a glycerol molecule within the active-site channel
-
-
?
additional information
?
-
-
active site of hDAO: contacts made by cofactor trihydroxyphenylalanine quinone to the active-site Cu2+, and Thr685 and to a glycerol molecule within the active-site channel
-
-
?
additional information
?
-
-
involvement of the enzyme in the supply of H2O2 to peroxidase-catalysed reactions in the chalazal cells during grain filling
-
-
?
additional information
?
-
-
low activity with histamine, n-butylamine, and 1,6-diaminohexane
-
-
?
additional information
?
-
-
low or no activity with 1,3-diaminopropane, N-methyl-1,3-diaminopropane, n-butylamine, 1,6-diaminohexane, and histamine
-
-
?
additional information
?
-
-
low activity with n-butylamine or 1,6-diaminohexane as substrate
-
-
?