1.4.3.22: diamine oxidase
This is an abbreviated version!
For detailed information about diamine oxidase, go to the full flat file.
Word Map on EC 1.4.3.22
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1.4.3.22
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polyamine
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oxidases
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monoamine
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mucosal
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copper
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spermidine
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deamination
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1.4.3.6
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aminoguanidine
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benzylamine
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endotoxin
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ornithine
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semicarbazide-sensitive
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occludin
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d-lactate
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copper-containing
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cadaverine
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bowel
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biogenic
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semicarbazide
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villus
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ileum
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d-lactic
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jejunal
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lysyl
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tyramine
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zonula
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piglets
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pao
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claudin-1
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methylamine
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n-methyltransferase
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pargyline
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agmatine
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tryptamine
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renalase
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hansenula
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occludens-1
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postheparin
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phenylhydrazine
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lentil
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deprenyl
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beta-aminopropionitrile
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oxidase-like
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clorgyline
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beta-phenylethylamine
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phenylethylamine
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quinoproteins
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samdc
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globiformis
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diagnostics
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analysis
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biotechnology
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medicine
- 1.4.3.22
- polyamine
- oxidases
-
monoamine
- mucosal
- copper
- spermidine
-
deamination
-
1.4.3.6
- aminoguanidine
- benzylamine
- endotoxin
- ornithine
-
semicarbazide-sensitive
- occludin
- d-lactate
-
copper-containing
- cadaverine
- bowel
-
biogenic
- semicarbazide
- villus
- ileum
-
d-lactic
- jejunal
-
lysyl
- tyramine
-
zonula
-
piglets
- pao
-
claudin-1
- methylamine
- n-methyltransferase
- pargyline
- agmatine
- tryptamine
- renalase
- hansenula
-
occludens-1
-
postheparin
- phenylhydrazine
- lentil
- deprenyl
- beta-aminopropionitrile
-
oxidase-like
- clorgyline
- beta-phenylethylamine
- phenylethylamine
-
quinoproteins
- samdc
- globiformis
- diagnostics
- analysis
- biotechnology
- medicine
Reaction
Synonyms
ABP1, AGAO, Amiloride-binding protein, Amine oxidase, BSAO, Copper amine oxidase, DAO, DAO-1, Diamine oxidase, EC 1.4.3.6, ELAO, GPAO, hDAO, histaminase, histamine dehydrogenase, histamine oxidase, LCAO, LSAO, methylputrescine oxidase, More, MPO, N-methylputrescine oxidase, pea seedling amine oxidase, PKAO, PPLO, PSAO, pWGH15, rhDAO, vDAO
ECTree
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Source Tissue
Source Tissue on EC 1.4.3.22 - diamine oxidase
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wounding results in an increase in the steady-state level of the enzyme expression both locally and systemically
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determination of fresh plasma diamine oxidase activity may serve as an effective tool to diagnose Cu deficiency in the bovine
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in vitro treatment with 100 nM, 0.05, 0.1 and 0.5 mM amitriptyline increases the guinea pig plasma diamine oxidase activity by 5, 7, 17 and 11%, respectively
mean/median concentrations are between 0.5 and 1.5 ng/ml in healthy volunteers (n=58) and mastocytosis patients (n=19) and plateau at approximately 145 ng/ml during pregnancy
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amitriptyline at 0.03, 0.05, 0.1 and 0.5 mM concentrations lower enzyme activity in the plasma of the heparinised rat by 14, 22, 23 and 28%, respectively
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the mean activity is 7.59 U/l for women and 2.38 U/l for men. Gender is a major determinant for DAO activity in healthy subjects
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variant ABP1 alleles leading to the amino-acid substitutions Thr16Met, Ser332Phe and His645Asp are identified with frequencies of 25.4, 6.3 and 30.6%, respectively. Over 70% of the population carry at least one amino-acid substitution. Individuals carrying the 645Asp amino acid display lower serum diamine oxidase activity as compared with noncarriers with a significant gene-dose effect. This is due to an increase in the Michaelis-Menten constant. Individuals heterozygous for 645Asp show Vmax/Km values of 66% and homozygous 51% as compared with noncarriers. The effect of the 16Met variant allele is lower and that of the rarest allele 332Phe is negligible
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a significantly lower serum diamine oxidase is found in the pseudoallergy group compared with the allergy group
mean/median concentrations are between 0.5 and 1.5 ng/ml in healthy volunteers (n=58) and mastocytosis patients (n=19) and plateau at approximately 145 ng/ml during pregnancy
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wounding results in an increase in the steady-state level of the enzyme expression both locally and systemically