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Literature summary for 1.4.3.22 extracted from

  • Frebort, I.; Tamaki, H.; Ishida, H.; Pec, P.; Luhova, L.; Tsuno, H.; Halata, M.; Asano, Y.; Kato, Y.; et al.
    Two distinct quinoprotein amine oxidases are induced by n-butylamine in the mycelia of Aspergillus niger AKU 3302. Purification, characterization, cDNA cloning and sequencing (1996), Eur. J. Biochem., 237, 255-265.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(E)-1,4-diamino-2-butene 0.1 mM, 72% and 87% inhibition; 0.1 mM, 72% and 87% inhibition Aspergillus niger
(Z)-1,4-diamino-2-butene 0.1 mM, 28% inhibition; 0.1 mM, 28% inhibition Aspergillus niger
1,4-phenanthroline
-
Aspergillus niger
1,5-Diamino-3-pentanone 1 mM, 50% inhibition; 1 mM, 50% inhibition Aspergillus niger
1-amino-3-phenyl-3-propanone
-
Aspergillus niger
2,2'-dipyridyl
-
Aspergillus niger
2,4-Dinitrophenylhydrazine 1 mM, complete inhibition; 1 mM, complete inhibition Aspergillus niger
p-Nitrophenylhydrazine 1 mM, complete inhibition; 1 mM, complete inhibition Aspergillus niger
phenylhydrazine 1 mM, complete inhibition; 1 mM, complete inhibition Aspergillus niger
Quinacrine 0.1 mM, 73% inhibition; 67% inhibition Aspergillus niger
sanguinarine 0.1 mM, 65% inhibition; 0.1 mM, 65% inhibition Aspergillus niger

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.15
-
aminohexane
-
Aspergillus niger

Metals/Ions

Metals/Ions Comment Organism Structure
copper 0.09-0.2 copper atoms per subunit Aspergillus niger
copper 0.5 copper atoms per subunit Aspergillus niger

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
2 * 75000, SDS-PAGE, deduced from nucleotide sequence Aspergillus niger
80000
-
gel filtration Aspergillus niger
150000
-
gel filtration Aspergillus niger

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
-
-
Aspergillus niger Q12556
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein less than 0.8% Aspergillus niger
glycoprotein less than 0.3% Aspergillus niger

Purification (Commentary)

Purification (Comment) Organism
-
Aspergillus niger

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Aspergillus niger
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.72
-
aminoheptane Aspergillus niger
1.74
-
aminoheptane Aspergillus niger
2.76
-
benzylamine Aspergillus niger
7.68
-
aminoheptane Aspergillus niger

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E,Z)-1,4-diamino-2-butene + H2O + O2
-
Aspergillus niger 4-aminobut-2-enal + NH3 + H2O2
-
?
1,4-diaminobutane + H2O + O2
-
Aspergillus niger 4-aminobutanal + NH3 + H2O2
-
?
1,5-diaminopentane + H2O + O2
-
Aspergillus niger 5-aminopentanal + NH3 + H2O2
-
?
aminobutane + H2O + O2
-
Aspergillus niger butanal + NH3 + H2O2
-
?
aminohexane + H2O + O2
-
Aspergillus niger hexanal + NH3 + H2O2
-
?
benzylamine + H2O + O2
-
Aspergillus niger benzaldehyde + NH3 + H2O2
-
?
histamine + H2O + O2
-
Aspergillus niger (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
-
Aspergillus niger p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
?
RCH2NH2 + H2O + O2
-
Aspergillus niger RCHO + NH3 + H2O2
-
?
tyramine + H2O + O2
-
Aspergillus niger 4-hydroxyphenylethanal + NH3 + H2O2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 75000, SDS-PAGE, deduced from nucleotide sequence Aspergillus niger
monomer 1 * 80000, SDS-PAGE Aspergillus niger

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Aspergillus niger

Cofactor

Cofactor Comment Organism Structure
2,4,5-trihydroxyphenylalanine quinone
-
Aspergillus niger