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(8-arginine)-vasopressin + H2O + O2
?
-
-
-
-
?
(8-lysine)-vasopressin + H2O + O2
?
-
-
-
-
?
(E)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
1,10-diaminodecane + H2O + O2
10-aminodecanal + NH3 + H2O2
1,2-diaminoethane + H2O + O2
2-aminoethanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
1,4-methylhistamine + H2O + O2
?
-
-
-
?
1,5-diamino-3-oxapentane + H2O + O2
?
-
the relative reaction rate with is 13% of that with putrescine
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
1,8-diamino-3,6-dioxaoctane + H2O + O2
?
-
the relative reaction rate with is 20% of that with putrescine
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
1,9-diaminononane + H2O + O2
9-aminononanal + NH3 + H2O2
-
-
-
?
1-aminobutane + H2O + O2
butanal + NH3 + H2O2
-
-
-
-
?
1-aminononane + H2O + O2
nonanal + NH3 + H2O2
-
-
-
-
?
1-methylhistamine + H2O + O2
?
-
-
-
-
?
1-phenylethylamine + H2O + O2
1-phenylethanal + NH3 + H2O2
2-(3,4-dihydroxyphenyl)-ethylamine + H2O + O2
3,4-dihydroxyphenylacetaldehyde + NH3 + H2O2
-
-
?
2-aminoethylpyridine + H2O + O2
pyridin-2-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
2-aminomethylpyridine + H2O + O2
2-formylpyridine + NH3 + H2O2
-
-
-
-
?
2-aminomethylpyridine + H2O + O2
2-pyridincarbaldehyde + NH3 + H2O2
-
-
-
-
?
2-hydroxycadaverine + H2O + O2
?
2-hydroxyputrescine + H2O + O2
2-hydroxy-4-aminobutanal + H2O2 + NH3
2-hydroxyputrescine + H2O + O2
?
2-methylhistamine + H2O + O2
?
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
r
3,3'-diaminobenzidine + H2O + O2
?
-
-
-
-
?
3-aminomethylpyridine + H2O + O2
3-formylpyridine + NH3 + H2O2
-
-
-
-
?
3-hydroxycadaverine + H2O + O2
3-hydroxy-4-aminopentanal + H2O2 + NH3
3-hydroxycadaverine + H2O + O2
?
4-aminomethylpyridine + H2O + O2
4-formylpyridine + NH3 + H2O2
4-aminomethylpyridine dihydrochloride + H2O + O2
?
8% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (putrescine, 1 mM) for various amine oxidases
-
-
?
4-dimethylaminomethylbenzylamine + H2O + O2
4-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
-
r
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
5-methylhistamine + H2O + O2
?
-
-
-
-
?
agmatine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
aminobutane + H2O + O2
butanal + NH3 + H2O2
aminohexane + H2O + O2
hexanal + NH3 + H2O2
aminopentane + H2O + O2
pentanal + NH3 + H2O2
-
-
?
aminopropane + H2O + O2
propanal + NH3 + H2O2
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
benzylamine + O2 + H2O
benzaldehyde + NH3 + H2O2
-
-
-
?
beta-phenylethylamine + O2 + H2O
beta-phenylethanal + NH3 + H2O2
-
-
-
?
butylamine + H2O + O2
?
-
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
cadaverine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
collagen + H2O + O2
?
-
-
-
-
?
cystamine + H2O + O2
2-mercaptoethanal + H2O2 + NH3
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
r
ethylenediamine + H2O + O2
?
hexylamine + H2O + O2
hexanal + NH3 + H2O2
-
41% of the activity with histamine
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
histamine + H2O + O2
?
-
48% activity compared to putrescine
-
-
?
histamine + O2 + H2O
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
L-lysine methyl ester + H2O + O2
?
lysine + H2O + O2
2-aminohexanoic acid + NH3 + H2O2
-
-
-
?
methylhistamine + H2O + O2
?
-
-
-
-
?
N(pi)-methylhistamine + H2O + O2
?
-
-
-
-
?
N(tau)-methylhistamine + H2O + O2
?
-
-
-
-
?
N-(2-fluoroethyl)putrescine + H2O + O2
N-(2-fluoroethyl)aminobutanal + NH3 + H2O2
-
same activity as with N-methylputrescine as substrate
-
-
?
N-acetyl-1,4-diaminobutane + H2O + O2
N-acetyl-aminobutanal + acetylamine + H2O2
-
8.6% of activity with putrescine
-
?
N-acetyl-1,5-diaminopentane + H2O + O2
N-acetyl-aminopentanal + acetylamine + H2O2
-
3.8% of activity with putrescine
-
?
N-acetylcadaverine + H2O + O2
?
-
-
-
-
r
N-ethylcadaverine + H2O + O2
5-(ethylamino)pentanal + NH3 + H2O2
-
17% activity compared to activity with N-methylputrescine
-
-
?
N-ethylputrescine + H2O + O2
4-(ethylamino)butanal + NH3 + H2O2
-
same activity as with N-methylputrescine as substrate
-
-
?
N-methyl-1,3-diaminopropane + H2O + O2
N-methyl-3-aminopropanal + NH3 + H2O2
N-methylcadaverine + H2O + O2
5-(methylamino)pentanal + NH3 + H2O2
-
16% activity compared to activity with N-methylputrescine
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
N-n-propylputrescine + H2O + O2
4-propylaminobutanal + NH3 + H2O2
-
50% of the activity compared to N-methylputrescine as substrate
-
-
?
N1-acetyl-spermidine + H2O + O2
?
-
8.6% of activity with putrescine
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2
?
N6-(4-aminobutyl)adenine + H2O + O2
?
N8-acetylspermidine + H2O + O2
?
-
-
-
-
?
norepinephrine + H2O + O2
?
-
-
-
?
octopamine + H2O + O2
?
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
?
-
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
pentylamine + H2O + O2
pentanal + NH3 + H2O2
-
32% of the activity with histamine
-
-
?
phenylethylamine + H2O + O2
?
-
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
phenylethylamine + H2O + O2
phenylethanal + NH3 + H2O2
propylamine + H2O + O2
propanal + NH3 + H2O2
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
putrescine + H2O + O2
? + NH3 + H2O2
putrescine + H2O + O2
gamma-aminobutyraldehyde + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
serotonin + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
1,3-diaminopropane + NH3 + H2O2
-
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
spermine + H2O + O2
? + NH3 + H2O2
tropocollagen + H2O + O2
?
-
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
tyramine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
tyramine + O2 + H2O
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
?
additional information
?
-
(E)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
(E)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
-
r
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
(E,Z)-1,4-diamino-2-butene + H2O + O2
4-aminobut-2-enal + NH3 + H2O2
-
-
-
?
1,10-diaminodecane + H2O + O2
10-aminodecanal + NH3 + H2O2
-
-
-
?
1,10-diaminodecane + H2O + O2
10-aminodecanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
109% of activity with putrescine
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
30% activity compared to activity with N-methylputrescine
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
30% activity compared to activity with putrescine
-
-
?
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
56% activity compared to activity with N-methylputrescine
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
50% activity compared to activity with N-methylputrescine
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
best substrate
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
best substrate
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,4-diaminobutane + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
most active
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
60% of activity with putrescine
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,5-diaminopentane + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,6-diaminohexane + H2O + O2
6-aminohexanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
-
?
1,7-diaminoheptane + H2O + O2
7-aminoheptanal + NH3 + H2O2
-
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
-
-
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
-
-
-
?
1,8-diaminooctane + H2O + O2
8-aminooctanal + NH3 + H2O2
-
-
-
?
1-phenylethylamine + H2O + O2
1-phenylethanal + NH3 + H2O2
-
44% of the activity with histamine
-
-
?
1-phenylethylamine + H2O + O2
1-phenylethanal + NH3 + H2O2
-
44% of the activity with histamine
-
-
?
2-hydroxycadaverine + H2O + O2
?
-
-
-
-
?
2-hydroxycadaverine + H2O + O2
?
-
-
-
-
?
2-hydroxyputrescine + H2O + O2
2-hydroxy-4-aminobutanal + H2O2 + NH3
-
-
-
?
2-hydroxyputrescine + H2O + O2
2-hydroxy-4-aminobutanal + H2O2 + NH3
-
-
-
?
2-hydroxyputrescine + H2O + O2
?
-
-
-
-
?
2-hydroxyputrescine + H2O + O2
?
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
3-hydroxycadaverine + H2O + O2
3-hydroxy-4-aminopentanal + H2O2 + NH3
-
-
-
?
3-hydroxycadaverine + H2O + O2
3-hydroxy-4-aminopentanal + H2O2 + NH3
-
-
-
?
3-hydroxycadaverine + H2O + O2
?
-
-
-
-
?
3-hydroxycadaverine + H2O + O2
?
-
-
-
-
?
4-aminomethylpyridine + H2O + O2
4-formylpyridine + NH3 + H2O2
-
-
-
-
?
4-aminomethylpyridine + H2O + O2
4-formylpyridine + NH3 + H2O2
-
-
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
72.6% of the activity with tyramine
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
53.6% of the activity with tyramine
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
19.3% of the activity with cadaverine
-
-
?
agmatine
?
-
14% of activity with putrescine
-
-
?
agmatine + H2O + O2
?
-
4% of the activity with histamine
-
-
?
agmatine + H2O + O2
?
-
4% of the activity with histamine
-
-
?
agmatine + H2O + O2
?
-
-
-
-
?
agmatine + H2O + O2
?
-
-
-
-
?
agmatine + H2O + O2
?
-
-
-
-
?
aminobutane + H2O + O2
butanal + NH3 + H2O2
-
-
?
aminobutane + H2O + O2
butanal + NH3 + H2O2
-
-
?
aminohexane + H2O + O2
hexanal + NH3 + H2O2
-
-
?
aminohexane + H2O + O2
hexanal + NH3 + H2O2
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
88.5% of the activity with tyramine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
29% activity compared to putrescine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
15.3% of the activity with tyramine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
66.5% of the activity with cadaverine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
-
22% of the activity with histamine
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
-
-
-
-
r
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
15% activity compared to activity with N-methylputrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
r
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
30% activity compared to activity with N-methylputrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
75% activity compared to activity with putrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
80% activity compared to activity with putrescine
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
r
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
5-aminopentanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
?
-
15.1% of the activity with tyramine
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
cadaverine + H2O + O2
?
-
12.0% of the activity with tyramine
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
cystamine + H2O + O2
2-mercaptoethanal + H2O2 + NH3
-
-
-
?
cystamine + H2O + O2
2-mercaptoethanal + H2O2 + NH3
-
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
51% of the activity with histamine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
93.7% of the activity with tyramine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
62.3% of the activity with tyramine
-
-
?
dopamine + H2O + O2
2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
18.4% of the activity with cadaverine
-
-
?
ethylenediamine + H2O + O2
?
-
-
-
-
?
ethylenediamine + H2O + O2
?
-
-
-
-
r
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
28% of activity with putrescine
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
preferred substrate
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
60% activity compared to activity with putrescine
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + O2 + H2O
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
DAO
-
-
?
histamine + O2 + H2O
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
degrades around 75% of the histamine used in a bioconversion experiment with a food-relevant concentration of 150 mg/l
-
-
?
histamine + O2 + H2O
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
degrades around 75% of the histamine used in a bioconversion experiment with a food-relevant concentration of 150 mg/l
-
-
?
L-lysine methyl ester + H2O + O2
?
-
-
-
-
?
L-lysine methyl ester + H2O + O2
?
-
-
-
-
?
N-methyl-1,3-diaminopropane + H2O + O2
N-methyl-3-aminopropanal + NH3 + H2O2
-
40% activity compared to activity with N-methylputrescine
-
-
?
N-methyl-1,3-diaminopropane + H2O + O2
N-methyl-3-aminopropanal + NH3 + H2O2
-
40% activity compared to activity with putrescine
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
best substrate
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
best substrate. Specificity for N-methylated diamines enable the Hyoscyamine enzyme to function specifically in tropane alkaloid biosynthesis
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
-
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
50% activity compared to activity with putrescine
-
-
?
N-methylputrescine + H2O + O2
4-(methylamino)butanal + NH3 + H2O2
-
75% activity compared to activity with putrescine
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-amino-trans-but-2-enyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-aminobutyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-aminobutyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-aminobutyl)adenine + H2O + O2
?
-
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-dimethylaminomethylbenzylamine + H2O + O2
p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
-
-
?
pargyline + H2O + O2
?
-
14.4% of the activity with tyramine
-
-
?
pargyline + H2O + O2
?
-
13.7% of the activity with tyramine
-
-
?
pargyline + H2O + O2
?
-
17.3% of the activity with cadaverine
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
r
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
phenylethanal + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
phenylethanal + NH3 + H2O2
-
-
-
-
?
propylamine + H2O + O2
propanal + NH3 + H2O2
-
7% of the activity with histamine
-
-
?
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
-
r
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
-
r
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
-
r
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
-
r
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
-
?
putrescine + H2O + O2
?
-
12.6% of the activity with tyramine
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
100% activity
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
catalytic activity of xenon-treated LSAO towards putrescine is about 40% of that of the native LSAO
-
-
?
putrescine + H2O + O2
?
-
11.5% of the activity with tyramine
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
96.2% of the activity with cadaverine
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
putrescine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
putrescine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with spermidine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with benzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with p-dimethylaminomethylbenzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
only aliphatic diamines from C4 to C10 and cystamine are oxidized, enzymatic activity decreases sharply with increasing chain length of diamines
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
short-chain aliphatic diamines are deaminated with highest reaction velocity
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with benzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with benzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
treatment of diamine oxidase with reducing agents induces ability to catalyze oxidative deamination of substrates of monoamine oxidase EC 1.4.3.4
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
71% activity compared to putrescine
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
r
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
no reaction
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
42% activity compared to putrescine
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
spermine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
tryptamine
?
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
15% of the activity with histamine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
35.2% of the activity with tyramine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
48.4% of the activity with tyramine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
15.7% of the activity with cadaverine
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
36% of the activity with histamine
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
36% of the activity with histamine
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
19.1% of the activity with cadaverine
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
additional information
?
-
-
no activity with putrescine, cadaverine, spermine, and spermidine
-
-
?
additional information
?
-
-
no activity with putrescine, cadaverine, spermine, and spermidine
-
-
?
additional information
?
-
-
relevance of the enzyme as a H2O2-delivering system in wound response, as well as in the protection against fungal invasion
-
-
?
additional information
?
-
-
polyamine degradation via DAO produces DELTA1-pyrroline, DELTA1-pyrroline can be catabolized to gamma-aminobutyric acid, which is converted via transamination and oxidation to succinate and successively introduced in the Krebs cycle.
-
-
?
additional information
?
-
hDAO is unique among CAOs in that it has a distinct substrate preference for diamines
-
-
?
additional information
?
-
-
hDAO is unique among CAOs in that it has a distinct substrate preference for diamines
-
-
?
additional information
?
-
active site of hDAO: contacts made by cofactor trihydroxyphenylalanine quinone to the active-site Cu2+, and Thr685 and to a glycerol molecule within the active-site channel
-
-
?
additional information
?
-
-
active site of hDAO: contacts made by cofactor trihydroxyphenylalanine quinone to the active-site Cu2+, and Thr685 and to a glycerol molecule within the active-site channel
-
-
?
additional information
?
-
-
involvement of the enzyme in the supply of H2O2 to peroxidase-catalysed reactions in the chalazal cells during grain filling
-
-
?
additional information
?
-
-
low activity with histamine, n-butylamine, and 1,6-diaminohexane
-
-
?
additional information
?
-
-
low or no activity with 1,3-diaminopropane, N-methyl-1,3-diaminopropane, n-butylamine, 1,6-diaminohexane, and histamine
-
-
?
additional information
?
-
-
low activity with n-butylamine or 1,6-diaminohexane as substrate
-
-
?
additional information
?
-
-
the enzyme does not degrade spermine
-
-
?
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(E)-1,4-diamino-2-butene
0.1 mM, 72% and 87% inhibition; 0.1 mM, 72% and 87% inhibition
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
-
i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo
1,10-phenanthroline
-
10 mM, 47% inhibition
1,4-diaminocyclohexane
-
5 mM, 69% inhibition
1,6-diamino-3-azahexane
-
competitive
1,8-diamino-3,6-dioxaoctane
-
-
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
1-amino-3-phenyl-3-propanone
-
1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
2,4-Dinitrophenylhydrazine
1 mM, complete inhibition; 1 mM, complete inhibition
2-ethylaminobenzylamine dihydrochloride
-
2-methylaminobenzylamine dihydrochloride
-
2-methylbenzothiazoline hydrazone
-
competitive inhibition
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
3-amino-4-aminomethylpyridine dihydrochloride
-
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
3-methylamino-4-aminomethylpyridine dihydrochloride
-
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
4,4'-(pentane-1,5-diylbis(oxy))dibenzimidamide
noncompetitive inhibition
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
4-(aminomethyl)-N,N'-bis(1-methylethyl)pyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
-
alpha,alpha'-dipyridyl
-
10 mM, 22% inhibition
amiloride
-
diuretic drug, competitive vs. agmatine and putrescine oxidation
aniline
-
10 mM, 43% inhibition
beta-hydroxyethylhydrazine
Ca2+
-
10 mM, 37% inhibition
CaCl2
-
1 mM, slightly inhibited,less than 24%
CdCl2
-
1 mM, strongly inhibited,more than 90%
cimetidine
mixed inhibition
CoCl2
-
1 mM, moderately inhibited,60-80%
CuCl2
-
1 mM, strongly inhibited,more than 90%
Cyclohexylamine
-
10 mM, 93% inhibition
Dicyclohexylamine
-
10 mM, 79% inhibition
Diethyl dithiocarbamate
-
10 mM, 76% inhibition
diethylenetriamine
-
powerful noncompetitive inhibitor
dithiothreitol
-
10 mM, 12% inhibition
EDTA-Na2
-
76.47% residual activity at 1 mM
EGTA
-
71.57% residual activity at 1 mM
Fe3+
-
10.78% residual activity at 3 mM
FeSO4
-
1 mM, moderately inhibited,60-80%
gabexate mesylate
-
anti coagulant drug, competitive vs. agmatine and putrescine oxidation
HgCl2
-
1 mM, strongly inhibited,more than 90%
hydrazine
-
10 mM, 95% inhibition
Iproniazide
-
10 mM, 43% inhibition
isoniazide
-
10 mM, 76% inhibition
Isonicotinic acid hydrazide
-
-
KMnO4
-
0.1 mM, complete inhibition
L-cysteine
-
complete inhibition at 0.1 mM
m-phenylenediamine
-
competitive vs. cadaverine
methylglyoxalbis(guanylhydrazone)
-
without preincubation competitive inhibitor, non-competitive after 1 h preincubation
methylhydrazine
-
10 mM, complete inhibition
MgCl2
-
1 mM, slightly inhibited,less than 24%
MnCl2
-
1 mM, slightly inhibited,less than 24%
N,N-diethyldithiocarbamate
-
the inactive enzyme is restored with Cu2+ to 65% of its initial activity
N-ethylmaleimide
-
1 mM, 90% inhibition
N-methyl-1,3-diamonopropane
N-Methylmaleimide
-
59% inhibition at 1 mM
N1,N2-bis(2-pyridinylmethyl)-1,2-ethanediamine
-
competitive
N1,N3-bis(2-pyridinylmethyl)-1,3-propanediamine
-
-
N1,N4-bis(2-pyridinylmethyl)-1,4-butanediamine
-
-
N1,N5-bis(2-pyridinylmethyl)-1,5-pentanediamine
-
-
N1,N6-bis(2-pyridinylmethyl)-1,6-hexanediamine
-
-
N1,N7-bis(2-pyridinylmethyl)-1,7-heptanediamine
-
-
N1,N8-bis(2-pyridinylmethyl)-1,8-octanediamine
-
-
N6-(3-aminopropyl)adenine
N6-(4-amino-cis-but-2-enyl)adenine
NaCl
-
200 mM, approx. 50% inhibition, almost complete inhibition of the purified enzyme with 1 M NaCl
NH3
-
competitive vs. p-dimethylaminomethylbenzylamine, uncompetitive vs. O2
Ni2+
-
0.5 mM, 92% inhibition
NiCl2
-
1 mM, moderately inhibited,60-80%
o-phenylenediamine
-
competitive vs. cadaverine
p-chloromercuribenzenesulfonic acid
-
91% inhibition at 1 mM
p-chloromercuriphenylsulfonate
-
1 mM, complete inhibition
p-Nitrophenylhydrazine
1 mM, complete inhibition; 1 mM, complete inhibition
Pentamidine
mixed inhibition
piperidine
-
10 mM, 55% inhibition
Pyridoxine-HCl
-
10 mM, 72% inhibition
sanguinarine
0.1 mM, 65% inhibition; 0.1 mM, 65% inhibition
spermidine
-
substrate inhibition
thiocyanate
-
uncompetitive vs. p-dimethylaminomethylbenzylamine, SCN- is equatorially coordinated to a tetragonal Cu(II) center
triethylenetetramine
-
powerful inhibitor
ZnCl2
-
1 mM, slightly inhibited,less than 24%
(Z)-1,4-diamino-2-butene
0.1 mM, 28% inhibition; 0.1 mM, 28% inhibition
(Z)-1,4-diamino-2-butene
-
-
1,3-diaminopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 32% relative inhibition
1,3-diaminopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 70% relative inhibition
1,3-diaminopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 93% relative inhibition
1,4-Diamino-2-butanone
-
-
1,4-Diamino-2-butanone
-
-
1,4-Diamino-2-butanone
-
potent reversible inhibitors
1,4-Diamino-2-butanone
-
potent reversible inhibitors
1,4-diamino-2-butyne
-
-
1,4-phenanthroline
-
1,4-phenanthroline
-
1 mM, 71% inhibition
1,4-phenanthroline
-
0.1 mM
1,5-Diamino-3-pentanone
1 mM, 50% inhibition; 1 mM, 50% inhibition
1,5-Diamino-3-pentanone
-
-
1,5-Diamino-3-pentanone
-
-
1,5-Diamino-3-pentanone
-
-
1,5-Diamino-3-pentanone
-
potent reversible inhibitors
1,5-Diamino-3-pentanone
-
potent reversible inhibitors
2,2'-dipyridyl
-
2,2'-dipyridyl
-
1 mM, 74% inhibition
2-mercaptoethanol
-
10 mM, 26% inhibition
2-mercaptoethanol
-
0.1 mM, 89% inhibition
2-mercaptoethanol
-
2.94% residual activity at 0.5 mM
8-hydroxyquinoline
-
10 mM, 24% inhibition
8-hydroxyquinoline
-
1 mM, 49.3% inhibition
aminoacetonitrile
-
-
aminoguanidine
-
-
aminoguanidine
-
0.00001 mM, 50% inhibition, putrescine or histamine as substrates
aminoguanidine
-
0.02 mM, complete inhibition, oxidation of histamine
aminoguanidine
-
1 mM, complete inhibition
aminoguanidine
potent, irreversible inhibitor
aminoguanidine
-
66% inhibition at 10 mM
aminoguanidine
-
0.03 mM, complete inhibition
aminoguanidine
-
model of inhibition mechanism
aminoguanidine
-
3.92% residual activity at 0.25 mM
Arcaine sulfate
-
-
azide
-
noncompetitive with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction
azide
-
partially competitive with respect to oxidative half-reaction, competitive with respect to reductive half-reaction
azide
-
mode of inhibition is dependent of azide concentration with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction
azide
-
competitive with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction
beta-aminopropionitrile
-
-
beta-aminopropionitrile
-
-
beta-Bromoethylamine
-
-
beta-hydroxyethylhydrazine
-
0.0033 mM, with 0.01 mM tyramine, 89.4% inhibition
beta-hydroxyethylhydrazine
-
0.0033 mM, with 0.01 mM tyramine, 89.5% inhibition
beta-hydroxyethylhydrazine
-
0.0033 mM, with 0.01 mM cadaverine, 85.5% inhibition
clonidine
mixed inhibition
clonidine
-
antihypertensive drug, competitive vs. agmatine and putrescine oxidation
Cu2+
-
0.5 mM, 92% inhibition
Cu2+
-
7.84% residual activity at 3 mM
Cuprizone
-
-
cyanide
-
-
cyanide
-
1 mM, 76% inhibition
diaminoacetone
-
0.1 mM, significant inhibition
diaminoacetone
-
0.1 mM, significant inhibition
diethyldithiocarbamate
-
0.0033 mM, with 0.01 mM tyramine, 95.1% inhibition
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
1 mM, complete inhibition
diethyldithiocarbamate
-
59% inhibition at 0.1 mM
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
0.0033 mM, with 0.01 mM tyramine, 90.4% inhibition
diethyldithiocarbamate
-
-
diethyldithiocarbamate
-
0.0033 mM, with 0.01 mM cadaverine, 91.2% inhibition
diethyldithiocarbamate
-
-
EDTA
-
10 mM, 18% inhibition
EDTA
-
10 mM, 80% inhibition
glutathione
-
0.0033 mM, with 0.01 mM tyramine, 35.2% inhibition
glutathione
-
0.0033 mM, with 0.01 mM tyramine, 43.5% inhibition
glutathione
-
0.0033 mM, with 0.01 mM cadaverine, 38.1% inhibition
H2O2
-
inactivation by turnover products is a slow reaction of the reduced protein with H2O2 subsequent to turnover and occurs in a similar way for all amines
H2O2
-
uncompetitive vs. p-dimethylaminomethylbenzylamine
Hg2+
-
10 mM, 80% inhibition
Hg2+
-
0.5 mM, complete inactivation
histamine
-
-
histamine
-
substrate inhibition
histamine
substrate inhibition at 0.5 mM
histamine
-
substrate inhibition at concentrations greater than 12.5 mM
hydroxylamine
-
40% inhibition at 0.01 mM
Hydroxyquinoline
-
-
Iproniazid
-
0.1 mM, 68% inhibition
Iproniazid
-
0.03 mM, 84% inhibition
isoniazid
-
-
isoniazid
noncompetitive inhibition
KCN
-
1 mM, inhibits activity completely, is used to stop the enzyme reaction
Mg2+
-
10 mM, 37% inhibition
Mg2+
-
78.43% residual activity at 3 mM
n-butylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 19% relative inhibition
n-butylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 66% relative inhibition
n-butylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 60% relative inhibition
N-methyl-1,3-diamonopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 34% relative inhibition
N-methyl-1,3-diamonopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 55% relative inhibition
N-methyl-1,3-diamonopropane
-
10 mM with 2 mM N-methylputrescine as substrate, 61% relative inhibition
N-methylbutylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 70% relative inhibition
N-methylbutylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 23% relative inhibition
N-methylbutylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 19% relative inhibition
N-methylpropylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 75% relative inhibition
N-methylpropylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 13% relative inhibition
N-methylpropylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 22% relative inhibition
n-Propylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 28% relative inhibition
n-Propylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 23% relative inhibition
n-Propylamine
-
10 mM with 2 mM N-methylputrescine as substrate, 48% relative inhibition
N6-(3-aminopropyl)adenine
-
noncompetitive
N6-(3-aminopropyl)adenine
-
competitive
N6-(3-aminopropyl)adenine
-
competitive
N6-(4-amino-cis-but-2-enyl)adenine
-
noncompetitive
N6-(4-amino-cis-but-2-enyl)adenine
-
competitive
N6-(4-amino-cis-but-2-enyl)adenine
-
competitive
Na2S2O3
-
0.0033 mM, with 0.01 mM tyramine, 20.7% inhibition
Na2S2O3
-
0.0033 mM, with 0.01 mM tyramine, 21.5% inhibition
Na2S2O3
-
0.0033 mM, with 0.01 mM cadaverine, 18.2% inhibition
NaCN
-
-
NaHSO3
-
0.0033 mM, with 0.01 mM tyramine, 19.5% inhibition
NaHSO3
-
0.0033 mM, with 0.01 mM tyramine, 19.3% inhibition
NaHSO3
-
0.0033 mM, with 0.01 mM cadaverine, 21.1% inhibition
NaN3
-
0.0033 mM, with 0.01 mM tyramine, 82.2% inhibition
NaN3
-
0.0033 mM, with 0.01 mM tyramine, 87.8% inhibition
NaN3
-
0.0033 mM, with 0.01 mM cadaverine, 85.6% inhibition
NaN3
-
uncompetitive vs. p-dimethylaminomethylbenzylamine, N3- is equatorially coordinated to a tetragonal Cu(II) center
o-phenanthroline
-
-
phenylhydrazine
-
10 mM, complete inhibition
phenylhydrazine
1 mM, complete inhibition; 1 mM, complete inhibition
phenylhydrazine
-
69% inhibition at 0.01 mM
Quinacrine
0.1 mM, 73% inhibition; 67% inhibition
Quinacrine
-
1 mM, complete inhibition
Semicarbazide
-
-
Semicarbazide
-
0.1 mM, 99% inhibition, oxidation of histamine
Semicarbazide
-
1 mM, complete inhibition
Semicarbazide
-
57% inhibition at 10 mM
Semicarbazide
very strong inhibition
tranylcypromine
-
-
triethyltetramine
-
-
additional information
-
not inhibited by pargyline
-
additional information
-
the recombinant enzyme is not inhibited by ethanol, acetaldehyde, disulfiram, diethyldithiocarbamate or cyanamide
-
additional information
-
inhibition by the copper ligand diethyldithiocarbamate and the carbonyl reagents suggests that copper and pyrrroloquinoline are present at the active site of this enzyme; primary amines inhibit pea and pig kidney DAO activities more strongly than the Hyoscyamus niger. N-methylated amines are stronger inhibitors of the Hyoscyamus enzyme than of the others DAOs
-
additional information
-
primary amines inhibit pea and pig kidney DAO activities more strongly than the Hyoscyamus niger. N-methylated amines are stronger inhibitors of the Hyoscyamus enzyme than of the others DAOs
-
additional information
clorgyline and deprenyl do not decrease DAO activity
-
additional information
-
no substrate inhibition with monoamines; substrate inhibition with diamines
-
additional information
alkylamino derivatives of 4-aminomethylpyridine, substrate-like, reversible inhibitors
-
additional information
-
primary amines inhibit pea and pig kidney DAO activities more strongly than the Hyoscyamus niger. N-methylated amines are stronger inhibitors of the Hyoscyamus enzyme than of the others DAOs
-
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Pisum sativum
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Gludovacz, E.; Maresch, D.; Bonta, M.; Szoelloesi, H.; Furtmueller, P.G.; Weik, R.; Altmann, F.; Limbeck, A.; Borth, N.; Jilma, B.; Boehm, T.
Characterization of recombinant human diamine oxidase (rhDAO) produced in Chinese Hamster Ovary (CHO) cells
J. Biotechnol.
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2016
Homo sapiens
brenda
Sujkowska-Rybkowska, M.; Borucki, W.
Localization of hydrogen peroxide accumulation and diamine oxidase activity in pea root nodules under aluminum stress
Micron
57
13-22
2014
Pisum sativum
brenda
Vuosku, J.; Muilu-Maekelae, R.; Avia, K.; Suokas, M.; Kestilae, J.; Laeaerae, E.; Haeggman, H.; Savolainen, O.; Sarjala, T.
Thermospermine synthase (ACL5) and diamine oxidase (DAO) expression is needed for zygotic embryogenesis and vascular development in Scots pine
Front. Plant Sci.
10
1600
2019
Pinus sylvestris (G8C850), Pinus sylvestris
brenda
Kacik, J.; Wroblewska, B.; Lewicki, S.; Zdanowski, R.; Kalicki, B.
Serum diamine oxidase in pseudoallergy in the pediatric population
Adv. Exp. Med. Biol.
1039
35-44
2018
Homo sapiens
brenda
Boehm, T.; Pils, S.; Gludovacz, E.; Szoelloesi, H.; Petroczi, K.; Majdic, O.; Quaroni, A.; Borth, N.; Valent, P.; Jilma, B.
Quantification of human diamine oxidase
Clin. Biochem.
50
444-451
2017
Homo sapiens (P19801), Homo sapiens
brenda
Boehm, T.; Karer, M.; Gludovacz, E.; Petroczi, K.; Resch, M.; Schuetzenberger, K.; Klavins, K.; Borth, N.; Jilma, B.
Simple, sensitive and specific quantification of diamine oxidase activity in complex matrices using newly discovered fluorophores derived from natural substrates
Inflamm. Res.
69
937-950
2020
Homo sapiens (P19801), Homo sapiens
brenda
Neree, A.T.; Pietrangeli, P.; Szabo, P.I.; Mateescu, M.A.; Marcocci, L.
Stability of vegetal diamine oxidase in simulated intestinal media protective role of cholic acids
J. Agric. Food Chem.
66
12657-12665
2018
Lathyrus sativus
brenda
Gludovacz, E.; Maresch, D.; Lopes de Carvalho, L.; Puxbaum, V.; Baier, L.J.; Suetzl, L.; Guedez, G.; Gruenwald-Gruber, C.; Ulm, B.; Pils, S.; Ristl, R.; Altmann, F.; Jilma, B.; Salminen, T.A.; Borth, N.; Boehm, T.
Oligomannosidic glycans at Asn-110 are essential for secretion of human diamine oxidase
J. Biol. Chem.
293
1070-1087
2018
Homo sapiens (P19801), Homo sapiens, Sus scrofa (Q9TRC7)
brenda
Kettner, L.; Braun, C.; Seitl, I.; Pross, E.; Fischer, L.
Production and characterization of a new diamine oxidase from Yarrowia lipolytica
J. Biotechnol.
340
39-46
2021
Yarrowia lipolytica, Yarrowia lipolytica PO1f
brenda
Kettner, L.; Seitl, I.; Fischer, L.
Evaluation of porcine diamine oxidase for the conversion of histamine in food-relevant amounts
J. Food Sci.
85
843-852
2020
Sus scrofa (Q9TRC7), Sus scrofa
brenda
Szego, A.; Mirmazloum, I.; Ponya, Z.; Bat-Erdene, O.; Omran, M.; Kiss-Baba, E.; Gyngyik, M.; Papp, I.
Downregulation of polyamine and diamine oxidases in silicon-treated cucumber
Plants (Basel)
10
1248
2021
Cucumis sativus
brenda
Neree, A.T.; Soret, R.; Marcocci, L.; Pietrangeli, P.; Pilon, N.; Mateescu, M.A.
Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles
Sci. Rep.
10
21563
2020
Lathyrus sativus
brenda