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Literature summary for 1.4.3.22 extracted from

  • Juda, G.A.; Shepard, E.M.; Elmore, B.O.; Dooley, D.M.
    A comparative study of the binding and inhibition of four copper-containing amine oxidases by azide: implications for the role of copper during the oxidative half-reaction (2006), Biochemistry, 45, 8788-8800.
    View publication on PubMed
Search for more literature for 1.4.3.22

Inhibitors

Inhibitors Comment Organism Structure
azide noncompetitive with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction Arthrobacter globiformis
azide partially competitive with respect to oxidative half-reaction, competitive with respect to reductive half-reaction Homo sapiens
azide mode of inhibition is dependent of azide concentration with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction Komagataella pastoris
azide competitive with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction Pisum sativum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0015
-
 Phenylethylamine 30°C, pH 7.2 Arthrobacter globiformis
0.014
-
 O2 30°C, pH 7.2 Homo sapiens
0.026
-
 putrescine 30°C, pH 7.2 Homo sapiens
0.033
-
 O2 30°C, pH 7.2 Arthrobacter globiformis
0.039
-
 Phenylethylamine 30°C, pH 7.0 Komagataella pastoris
0.041
-
 O2 30°C, pH 7.0 Komagataella pastoris
0.046
-
 O2 30°C, pH 7.2 Pisum sativum
0.424
-
 putrescine 30°C, pH 7.2 Pisum sativum

Organism

Organism UniProt Comment Textmining
Arthrobacter globiformis
-
-
-
Homo sapiens
-
 recombinant
-
Komagataella pastoris
-
-
-
Pisum sativum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
 Pisum sativum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phenylethylamine + H2O + O2
-
 Arthrobacter globiformis 2-phenylethanal + NH3 + H2O2
-
 ?
2-phenylethylamine + H2O + O2
-
 Komagataella pastoris phenylacetaldehyde + NH3 + H2O2
-
 r
benzylamine + H2O + O2
-
 Komagataella pastoris benzaldehyde + NH3 + H2O2
-
 ?
phenylethylamine + H2O + O2
-
 Komagataella pastoris phenylacetaldehyde + NH3 + H2O2
-
 r
putrescine + H2O + O2
-
 Homo sapiens ?
-
 ?
putrescine + H2O + O2
-
 Pisum sativum ?
-
 ?

Synonyms

Synonyms Comment Organism
AGAO
-
 Arthrobacter globiformis
PPLO
-
 Komagataella pastoris
PSAO
-
 Pisum sativum
rhDAO
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.308
-
 O2 30°C, pH 7.2, per dimer Pisum sativum
4
-
 O2 30°C, pH 7.2, per dimer Homo sapiens
7.9
-
 putrescine 30°C, pH 7.2, per dimer Homo sapiens
11.2
-
 2-Phenylethylamine 30°C, pH 7.0, per dimer Komagataella pastoris
12.6
-
 O2 30°C, pH 7.0, per dimer Komagataella pastoris
44
-
 2-Phenylethylamine 30°C, pH 7.2, per dimer Arthrobacter globiformis
53
-
 O2 30°C, pH 7.2, per dimer Arthrobacter globiformis
252
-
 putrescine 30°C, pH 7.2, per dimer Pisum sativum

Cofactor

Cofactor Comment Organism Structure
2,4,5-trihydroxyphenylalanine quinone i.e. iminoquinone, content of 2,4,5-trihydroxyphenylalanine quinone per dimer is 1.4 Homo sapiens
2,4,5-trihydroxyphenylalanine quinone i.e. iminoquinone, content of 2,4,5-trihydroxyphenylalanine quinone per dimer is 1.4 Arthrobacter globiformis
2,4,5-trihydroxyphenylalanine quinone i.e. iminoquinone, content of 2,4,5-trihydroxyphenylalanine quinone per dimer is 1.6 Komagataella pastoris
2,4,5-trihydroxyphenylalanine quinone i.e. iminoquinone, content of 2,4,5-trihydroxyphenylalanine quinone per dimer is 1.8 Pisum sativum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
18
-
 azide 30°C, pH 7.2, with respect to reductive half-reaction Arthrobacter globiformis
19
-
 azide 30°C, pH 7.2, with respect to oxidative half-reaction Arthrobacter globiformis
23
-
 azide 30°C, pH 7.0, with respect to oxidative half-reaction Komagataella pastoris
26
-
 azide 30°C, pH 7.0, with respect to reductive half-reaction Komagataella pastoris
31
-
 azide 30°C, pH 7.2, with respect to oxidative half-reaction Pisum sativum
37
-
 azide 30°C, pH 7.2, with respect to reductive half-reaction Homo sapiens
92
-
 azide 30°C, pH 7.2, with respect to oxidative half-reaction Homo sapiens
250
-
 azide 30°C, pH 7.2, with respect to reductive half-reaction Pisum sativum