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Literature summary for 1.4.3.22 extracted from
- Characterization of diamine oxidase from human seminal plasma (2013), J. Neural Transm., 120, 983-986.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.031 | - |
spermine | enzyme from seminal plasma, at 37°C, pH not specified in the publication | Homo sapiens |  |
| 0.033 | - |
spermidine | enzyme from seminal plasma, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.055 | - |
spermine | enzyme from placenta, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.057 | - |
spermidine | enzyme from placenta, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.063 | - |
putrescine | enzyme from seminal plasma, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.075 | - |
Methylhistamine | enzyme from seminal plasma, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.094 | - |
putrescine | enzyme from placenta, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.108 | - |
histamine | enzyme from seminal plasma, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.124 | - |
histamine | enzyme from placenta, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.158 | - |
Methylhistamine | enzyme from placenta, at 37°C, pH not specified in the publication | Homo sapiens | |
| 0.877 | - |
Butylamine | enzyme from placenta, at 37°C, pH not specified in the publication | Homo sapiens | |
| 2.032 | - |
Butylamine | enzyme from seminal plasma, at 37°C, pH not specified in the publication | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 102000 | - |
2 * 102000, SDS-PAGE | Homo sapiens |
| 200000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| histamine + H2O + O2 | Homo sapiens | - |
(imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| heparin-Sepharose column chromatography, phenyl-Sepharose column chromatography, CIM-QA column chromatography, and Superdex 200 gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
| seminal plasma | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.141 | - |
unpurified enzyme, at 37°C, pH not specified in the publication | Homo sapiens |
| 32.7 | - |
after 233fold purification, at 37°C, pH not specified in the publication | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butylamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
| histamine + H2O + O2 | - |
Homo sapiens | (imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
| methylhistamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
| putrescine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
| spermidine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
| spermine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 102000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DAO | - |
Homo sapiens |
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